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Total 1739 results found since Jan 2013.

Overview of programmed electrical stimulation to assess atrial fibrillation susceptibility in mice
Atrial fibrillation (AF) is the most common human arrhythmia and is associated with increased risk of stroke, dementia, heart failure, and death. Among several animal models that have been used to investigate the molecular determinants of AF, mouse models have become the most prevalent due to low cost, ease of genetic manipulation, and similarity to human disease. Programmed electrical stimulation (PES) using intracardiac or transesophageal atrial pacing is used to induce AF as most mouse models do not develop spontaneous AF. However, there is a lack of standardized methodology resulting in numerous PES protocols in the li...
Source: Frontiers in Physiology - April 11, 2023 Category: Physiology Source Type: research

Different aspects of hand grip performance associated with structural connectivity of distinct sensorimotor networks in chronic stroke
Different aspects of hand grip performance may be associated with the structural connectivity of distinct sensorimotor networks in chronic stroke survivors. This knowledge may facilitate the development of personalized rehabilitation interventions to target the responsible brain network for specific motor impairments in individual patients, thus improving outcomes. AbstractKnowledge regarding the neural origins of distinct upper extremity impairments may guide the choice of interventions to target neural structures responsible for specific impairments. This cross-sectional pilot study investigated whether different brain n...
Source: Physiological Reports - April 6, 2023 Category: Physiology Authors: Christian Schranz, Shraddha Srivastava, Bryant A. Seamon, Barbara Marebwa, Leonardo Bonilha, Viswanathan Ramakrishnan, Janina Wilmskoetter, Richard R. Neptune, Steve A. Kautz, Na Jin Seo Tags: ORIGINAL ARTICLE Source Type: research

Towards continuous EIT monitoring for hemorrhagic stroke patients
The practical implementation of continuous monitoring of stroke patients by Electrical Impedance Tomography (EIT) is addressed. In a previous paper, we have demonstrated EIT sensitivity to cerebral hemodynamics, using scalp-mounted electrodes, very low-noise measurements, and a novel image reconstruction method. In the present paper, we investigate the potential to adapt that system for clinical application, by using 50% fewer electrodes and by incorporating into the measurement protocol an additional high-frequency measurement to provide an effective reference. Previously published image reconstruction methods for multi-f...
Source: Frontiers in Physiology - April 5, 2023 Category: Physiology Source Type: research

Preeclampsia history and postpartum risk of cerebrovascular disease and cognitive impairment: Potential mechanisms
Hypertensive disorders of pregnancy such as preeclampsia, eclampsia, superimposed preeclampsia, and gestational hypertension are major causes of fetal and maternal morbidity and mortality. Women with a history of hypertensive pregnancy disorders have increased risk of stroke and cognitive impairments later in life. Moreover, women with a history of preeclampsia have increased risk of mortality from diseases including stroke, Alzheimer’s disease, and cardiovascular disease. The underlying pathophysiological mechanisms are currently not fully known. Here, we present clinical, epidemiological, and preclinical studies focuse...
Source: Frontiers in Physiology - March 31, 2023 Category: Physiology Source Type: research

Developing a real-time detection tool and an early warning score using a continuous wearable multi-parameter monitor
Conclusion: As the new detection and warning tool is based on highly-frequent monitoring capabilities, it provides medical teams with timely alerts of pre-symptomatic and real-time deterioration.
Source: Frontiers in Physiology - March 29, 2023 Category: Physiology Source Type: research

Relationship between motor performance and cortical activity of older neurological disorder patients with dyskinesia using fNIRS: A systematic review
Conclusion: Most of the reviewed studies reported poor motor performance and increased cortical activation of PD, stroke and multiple sclerosis older patients. The external motor performance such as step speed were analyzed only. The design and results were not comprehensive and profound. More than 5 weeks walking training or physiotherapy can contribute to motor function promotion as well as cortices activation of PD and stroke patients. Thus, further study is needed for more statistical analysis on the relationship between motor performance and activation of the motor-related cortex. More different type and program spor...
Source: Frontiers in Physiology - March 27, 2023 Category: Physiology Source Type: research

Whole genome transcriptomic reveals heat stroke molecular signatures in humans
This article is protected by copyright. All rights reserved.PMID:36951421 | DOI:10.1113/JP284031
Source: The Journal of Physiology - March 23, 2023 Category: Physiology Authors: Abderrezak Bouchama Mamoon Rashid Shuja Shafi Malik Saeed Almahri Yara Yassin Mashan Abdullah Nour Abdulmalek Fuad Maashi Abdulaziz Mashi Altaf Khan Badriah Alotaibi Cynthia Lehe Sameer Mohammad Haitham Alkadi Deemah Al Waadani Saber Yezli Source Type: research

Concurrent validity of machine learning-classified functional upper extremity use from accelerometry in chronic stroke
Conclusion: Our machine learning approach provides a valid measure of functional UE use. The accuracy, validity, and small footprint of this machine learning approach makes it feasible for measurement of UE recovery in stroke rehabilitation trials.
Source: Frontiers in Physiology - March 22, 2023 Category: Physiology Source Type: research

The in vivo study of cardiac mechano-electric and mechano-mechanical coupling during heart development in zebrafish
In the adult heart, acute adaptation of electrical and mechanical activity to changes in mechanical load occurs via feedback processes known as “mechano-electric coupling” and “mechano-mechanical coupling.” Whether this occurs during cardiac development is ill-defined, as acutely altering the heart’s mechanical load while measuring functional responses in traditional experimental models is difficult, as embryogenesis occurs in utero, making the heart inaccessible. These limitations can be overcome with zebrafish, as larvae develop in a dish and are nearly transparent, allowing for in vivo manipulation and measure...
Source: Frontiers in Physiology - March 16, 2023 Category: Physiology Source Type: research

Physiological and biomechanical responses to exercise on two different types of rowing ergometers in NCAA Division I oarswomen
ConclusionRowing on the DE appears to elicit a greater stroke rate and more optimal joint angles especially at high intensities. Hence, the DE is worthy of consideration as a preferred ergometer for women rowers.
Source: European Journal of Applied Physiology - March 16, 2023 Category: Physiology Source Type: research

Repair of traumatic lesions to the plasmalemma of neurons and other cells: Commonalities, conflicts, and controversies
We describe current research gaps and potential future developments, such as much more extensive correlations of biochemical/biophysical measures with sub-cellular micromorphology. We compare and contrast naturally occurring sealing with recently-discovered artificially-induced plasmalemmal sealing by polyethylene glycol (PEG) that bypasses all natural pathways for membrane repair. We assess other recent developments such as adaptive membrane responses in neighboring cells following injury to an adjacent cell. Finally, we speculate how a better understanding of the mechanisms involved in natural and artificial plasmalemmal...
Source: Frontiers in Physiology - March 15, 2023 Category: Physiology Source Type: research

Quantitative assessment of biceps brachii muscle stiffness by using Young ’s modulus–Angle curve during passive stretching in stroke patients
Conclusion: The passive elastic characteristics of the biceps brachii are consistent with the exponential model. The Young’s modulus–elbow angle curve of the biceps brachii changes in distinct ways depending on the muscle tone status. SWE can be used to quantify muscular stiffness during passive stretching as a new way of muscle tone evaluation, allowing for quantitative muscle tone evaluation and mathematical assessment of muscle mechanical properties in stroke patients.
Source: Frontiers in Physiology - March 8, 2023 Category: Physiology Source Type: research