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Total 1739 results found since Jan 2013.

Long-term circadian disruption shortens lifespan and dampens blood pressure diurnal rhythms in stroke-prone spontaneously hypertensive rats
Am J Physiol Heart Circ Physiol. 2023 May 19. doi: 10.1152/ajpheart.00055.2023. Online ahead of print.ABSTRACTEnvironmental cues such as light and timing of food intake influence molecular clocks that produce circadian rhythmicity of many biological functions. The master circadian clock is entrained by light input and synchronizes to peripheral clocks in every organ. Careers that require rotating shift work schedules predispose workers to a constant desynchronization of biological clocks and are associated with increased risk of cardiovascular disease. We utilized a stroke-prone spontaneously hypertensive rat model exposed...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 19, 2023 Category: Physiology Authors: Anne M Ramsey Adam Stowie Atlantis Hill Ivory Ellis Megan Rhoads David M Pollock Alec J Davidson Source Type: research

Influence of accelerated arterial ageing in growth restricted cohorts on adult-onset cardiovascular diseases
Am J Physiol Heart Circ Physiol. 2023 May 19. doi: 10.1152/ajpheart.00134.2023. Online ahead of print.ABSTRACTEpidemiologists have long documented higher risk of adult-onset cardiovascular diseases (CVD) such as stroke, hypertension and coronary artery disease) and mortality from circulatory causes in low birth weight cohorts (poor in utero substrate supply). Utero-placental insufficiency and in utero hypoxemic state induced alterations in arterial structure and compliance are important initiating factors for adult-onset hypertension. The mechanistic links between fetal growth restriction and CVD include decreased arterial...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 19, 2023 Category: Physiology Authors: Arvind Sehgal Beth J Allison F àtima Crispi Samuel Menahem Source Type: research

Autocompletion of repetitive stroking with image guidance
We present an assisted drawing system to autocomplete repetitive short strokes during a user ’s normal drawing process. Users draw over a reference image as usual; at the same time, our system silently analyzes the input strokes and the reference to infer strokes that follow the user’s input style when certain repetition is detected. Users can accept, modify, or ignore the system’s pr edictions and continue drawing, thus maintaining fluid control over drawing. Our key idea is to jointly analyze image regions and user input history to detect and predict repetition. The proposed system can effectively reduce the user�...
Source: European Journal of Applied Physiology - May 18, 2023 Category: Physiology Source Type: research

Peripheral skin cooling during hyper-gravity: hemodynamic reactions
Conclusion: In conclusion, PSC during +Gz did not confer any significant impact on hemodynamic activity or orthostatic stability during +Gz. This may be due to lower PSC responsiveness of the test subjects, or an insufficient level of body surface area used for cooling. Further investigations are warranted in order to comprehensively pinpoint the exact degree of PSC needed to serve as a useful countermeasure system during +Gz.
Source: Frontiers in Physiology - May 15, 2023 Category: Physiology Source Type: research

The ventilatory component of the muscle metaboreflex is overstimulated in transthyretin cardiac amyloidosis patients with poor aerobic capacity
Conclusion: Consistent with the “muscle hypothesis” in heart failure, it is proposed that deterioration of skeletal muscle function in hereditary CA-TTR patients may activate muscle metaboreflex, leading to an increase in ventilation and sensation of breathlessness, the perception of fatigue, and overall sympathetic activation.
Source: Frontiers in Physiology - May 15, 2023 Category: Physiology Source Type: research

Wrist ballistocardiography and invasively recorded blood pressure in healthy volunteers during reclining bike exercise
Objective: Ballistocardiogram (BCG) features are of interest in wearable cardiovascular monitoring of cardiac performance. We assess feasibility of wrist acceleration BCG during exercise for estimating pulse transit time (PTT), enabling broader cardiovascular response studies during acute exercise and improved monitoring in individuals at risk for cardiovascular disease (CVD). We also examine the relationship between PTT, blood pressure (BP), and stroke volume (SV) during exercise and posture interventions.Methods: 25 participants underwent a bike exercise protocol with four incremental workloads (0 W, 50 W, 100 W, and ...
Source: Frontiers in Physiology - May 12, 2023 Category: Physiology Source Type: research

Linking cortex and contraction —Integrating models along the corticomuscular pathway
Computational models of the neuromusculoskeletal system provide a deterministic approach to investigate input-output relationships in the human motor system. Neuromusculoskeletal models are typically used to estimate muscle activations and forces that are consistent with observed motion under healthy and pathological conditions. However, many movement pathologies originate in the brain, including stroke, cerebral palsy, and Parkinson’s disease, while most neuromusculoskeletal models deal exclusively with the peripheral nervous system and do not incorporate models of the motor cortex, cerebellum, or spinal cord. An integr...
Source: Frontiers in Physiology - May 10, 2023 Category: Physiology Source Type: research

How to create a nervous system aneurysm model in canines? ligation of the lingual artery is a simple and effective method
Conclusion: We have established a safe, effective, stable and simple method to establish a canine nervous system aneurysm model with controllable size. In addition, this method has the advantages of no arteriotomy, less trauma, constant anatomical location, and low risk of stroke.
Source: Frontiers in Physiology - May 5, 2023 Category: Physiology Source Type: research

Effects of EMG-based robot for upper extremity rehabilitation on post-stroke patients: a systematic review and meta-analysis
Conclusion: The effect of EMG-based robot is superior to conventional therapies in terms of improving upper extremity motor control, spasticity and activity limitation. Further research should explore optimal parameters of EMG-based robot therapy and its long-term effects on upper limb function in post-stroke patients.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/; Identifier: 387070.
Source: Frontiers in Physiology - May 3, 2023 Category: Physiology Source Type: research

Investigating spatial variations in dynamic cerebral autoregulation through a computational model of stenosis
Objective. Dynamic cerebral autoregulation (dCA) is a well-established mechanism that acts to maintain cerebral blood flow (CBF) reasonably constant in response to short-term fluctuations in blood pressure. It is known to be impaired in many clinical conditions, including stenosis, which is also a major risk factor for ischaemic stroke. However, it is not yet well understood whether impairment in dCA in one brain region is independent or not on dCA impairment in other brain regions, for example, whether there are spatial effects of stenosis on dCA. This is due to the complex blood flow environment and the lack of physiolog...
Source: Physiological Measurement - April 18, 2023 Category: Physiology Authors: Zheng Tong and Stephen J Payne Source Type: research

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