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Specialty: Biochemistry
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Total 1283 results found since Jan 2013.
Association of Angiotensin II Type 1 Receptor (AT1R) Gene Polymorphism with Angiotensin II Serum Levels in Patients with Essential Hypertension
This study aimed to determine genotype and allele frequencies of A1166C polymorphism of AT1R gene in Indian patients with EH and correlated with serum levels of Angiotensin II. A total of 200 patients with EH and 200 age- and gender-matched control individuals were included in this study from the General Medicine Department Outpatient at Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India. Patients with systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg were considered as hypertensive. The findings of this study revealed significantly increased risk of C/A heteroz...
Source: Clinical Biochemistry - January 23, 2023 Category: Biochemistry Authors: M Prasad D Rajarajeswari K Ramlingam R Viswakumar B Suneel Jyothi Conjeevaram P Aruna Nusrath Fathima Sandeep Kumar Vishwakarma Aleem Ahmed Khan Source Type: research
Qilong capsule alleviated MPTP-induced neuronal defects by inhibiting apoptosis, regulating autophagy in zebrafish embryo model
Chem Biodivers. 2023 Jan 20. doi: 10.1002/cbdv.202200926. Online ahead of print.ABSTRACTQilong capsule (QLC) originates from the famous "Buyang Huanwu decoction" prescription. It is representative of drugs used in China during recovery from stroke, but its neuroprotective mechanism of action remains obscure. HPLC was used to evaluate the similarity of 10 batches of QLC samples. Then we used a zebrafish model to study the neuroprotective effect of QLC. At 24 hpf, embryos were treated with QLC and 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), and zebrafish were observed the neuronal length and the number of apoptot...
Source: Chemistry and Biodiversity - January 20, 2023 Category: Biochemistry Authors: Cailian Mo Shenghua Lin Zhen Li Xin Liu Suyan Ye Huiliang Liang Honglin Ma Chuanlin Shen Wei Fan Yuying Wang Kechun Liu Qiuxia He Source Type: research
Self-assembled DNA nanocages promote cell migration & amp; differentiation of human umbilical vein endothelial cells
Chembiochem. 2023 Jan 16. doi: 10.1002/cbic.202200634. Online ahead of print.ABSTRACTDNA nanocages have been explored for capabilities to influence cellular behavior and its functions. Recent times have seen the development of new emergent functionalities of DNA nanodevices as class of biomaterials with immense capacity to interface with biological systems and having vast potential in disease diagnosis and therapeutics. Being chemically robust and biocompatible in nature, DNA nanocages have been surface modified and structurally fine-tuned to find emerging applications in the field of stem cell therapy and tissue regenerat...
Source: Chembiochem - January 16, 2023 Category: Biochemistry Authors: Anjali Rajwar Gada Payal Vaswani Ramesh Singh Dhiraj Devidas Bhatia Source Type: research
TMT proteomics analysis of cerebrospinal fluid from patients with cerebral venous sinus thrombosis
J Proteomics. 2023 Jan 13:104820. doi: 10.1016/j.jprot.2023.104820. Online ahead of print.ABSTRACTCVST is a type of venous stroke that mainly affects young adults with no reliable diagnostic markers and effective treatment strategies for secondary pathologies. However, the underlying pathological molecular mechanisms remain unclear. Here, we systematically analyzed the molecule profiling of the cerebrospinal fluid (CSF) in CVST patients via tandem mass tag (TMT)-based proteomics for the first time, aiming to reveal the pathogenesis and provide evidence for the diagnosis and treatment of CVST. Five CVST patients and five co...
Source: Journal of Proteomics - January 16, 2023 Category: Biochemistry Authors: Yaqi Liu Rui Ding Meng Li Weiyang Ou Xifang Zhang Weijie Yang Xiaofei Huang Huihui Chai Qiujing Wang Source Type: research
Self-assembled DNA nanocages promote cell migration & amp; differentiation of human umbilical vein endothelial cells
Chembiochem. 2023 Jan 16. doi: 10.1002/cbic.202200634. Online ahead of print.ABSTRACTDNA nanocages have been explored for capabilities to influence cellular behavior and its functions. Recent times have seen the development of new emergent functionalities of DNA nanodevices as class of biomaterials with immense capacity to interface with biological systems and having vast potential in disease diagnosis and therapeutics. Being chemically robust and biocompatible in nature, DNA nanocages have been surface modified and structurally fine-tuned to find emerging applications in the field of stem cell therapy and tissue regenerat...
Source: Chembiochem - January 16, 2023 Category: Biochemistry Authors: Anjali Rajwar Gada Payal Vaswani Ramesh Singh Dhiraj Devidas Bhatia Source Type: research
The role of miRNAs in insulin resistance and diabetic macrovascular complications - A review
Int J Biol Macromol. 2023 Jan 6:123189. doi: 10.1016/j.ijbiomac.2023.123189. Online ahead of print.ABSTRACTDiabetes is the most prevalent metabolic disturbance disease and has been regarded globally as one of the principal causes of mortality. Diabetes is accompanied by several macrovascular complications, including stroke, coronary artery disease (CAD), and cardiomyopathy as a consequence of atherosclerosis. The onset of type 2 diabetes is closely related to insulin resistance (IR). miRNAs have been linked to various metabolic processes, including glucose homeostasis, regulation of lipid metabolism, gluconeogenesis, adipo...
Source: International Journal of Biological Macromolecules - January 9, 2023 Category: Biochemistry Authors: Sherif S Abdel Mageed Ahmed S Doghish Ahmed Ismail Ahmed A El-Husseiny Sylvia F Fawzi Abdulla M A Mahmoud Hesham A El-Mahdy Source Type: research
Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats
Mol Cell Biochem. 2023 Jan 7. doi: 10.1007/s11010-022-04653-4. Online ahead of print.ABSTRACTStroke cachexia is associated with prolonged inflammation, muscle loss, poor prognosis, and early death of stroke patients. No particular treatment is available to cure the symptoms or disease. The present study aimed to evaluate the effect of a 5-HT1a agonist, buspirone on stroke cachexia. Wistar rats were injected with endothelin-1 to the bregma region of the brain to induce ischemic stroke followed by induction of cachexia after 4 days. Treatment with buspirone (3 mg/kg p.o) was given for 4 weeks after confirmation of cachexia i...
Source: Molecular and Cellular Biochemistry - January 7, 2023 Category: Biochemistry Authors: Darshak Shah Mit Joshi Jigna Shah Bhoomika M Patel Source Type: research
MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway
This study aims to explore whether MALT1 is upregulated in the brain during ischemic stroke and promotes brain cell necroptosis through enhancing the degradation of A20. Ischemic stroke model was established in Sprague Dawley rats by occlusion of the middle cerebral artery (MCA) for 2 h, followed by 24 h reperfusion, which showed brain injury (increase in neurological deficit score and infarct volume) concomitant with an upregulation of MALT1, a decrease in A20 level, and increases in necroptosis-associated protein levels [RIPK3, mixed lineage kinase domain-like protein (MLKL) and p-MLKL] and k63-ubiquitination of RIPK3 in...
Source: Archives of Biochemistry and Biophysics - January 5, 2023 Category: Biochemistry Authors: Zi-Mei Peng Yi-Yue Zhang Dan Wei Xiao-Jie Zhang Bin Liu Jun Peng Xiu-Ju Luo Source Type: research
