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Specialty: Biochemistry
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Total 1283 results found since Jan 2013.
The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms
Biochimie. 2022 Oct 15:S0300-9084(22)00274-7. doi: 10.1016/j.biochi.2022.10.009. Online ahead of print.ABSTRACTThe global epidemic of diabetes has brought heavy pressure on public health. New effective anti-diabetes strategies are urgently needed. Trigonelline is the main component of fenugreek, which has been proved to have a good therapeutic effect on diabetes and diabetic complications. Trigonelline achieves amelioration of diabetes, the mechanisms of which include the modulation of insulin secretion, a reduction in oxidative stress, and the improvement of glucose tolerance and insulin resistance. Besides, trigonelline ...
Source: Biochimie - October 18, 2022 Category: Biochemistry Authors: Youdan Liang Xiaolin Dai Yi Cao Xian Wang Jing Lu Long Xie Kai Liu Xiaofang Li Source Type: research
MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1
CONCLUSION: Collectively, exosomal miR-145-derived from MSCs was able to attenuate cerebral I/R injury through downregulation of FOXO1. These studies may serve as a potential approach for treating of cerebral I/R injury.PMID:36206599 | DOI:10.1016/j.bbrc.2022.09.089
Source: Biochemical and Biophysical Research communications - October 7, 2022 Category: Biochemistry Authors: Hai Zhou Jing Zhou Hongwei Teng Hua Yang Jinsong Qiu Xiangdong Li Source Type: research
Primary astrocytic mitochondrial transplantation ameliorates ischemic stroke
In this study, we observed that treatment with mitochondria isolated from rat primary astrocytes enhanced cell viability and ameliorated hydrogen peroxide-damaged neurons. Interestingly, isolated astrocytic mitochondria increased the number of cells under damaged neuronal conditions, but not under normal conditions, although the mitochondrial transfer efficiency did not differ between the two conditions. This effect was also observed after transplanting astrocytic mitochondria in a rat middle cerebral artery occlusion model. These findings suggest that mitochondria transfer therapy can be used to treat acute ischemic strok...
Source: BMB Reports - October 4, 2022 Category: Biochemistry Authors: Eun-Hye Lee Minkyung Kim Seung Hwan Kim Chun-Hyung Kim Minhyung Lee Chang-Hwan Park Source Type: research
Synthesis, Docking Study and Biological Evaluation of Amide-Based Soluble Epoxide Hydrolase Inhibitors with Novel Secondary Pharmacophore of Pyrimidin-2-ol
Chem Biodivers. 2022 Sep 24. doi: 10.1002/cbdv.202200231. Online ahead of print.ABSTRACTSoluble epoxide hydrolase enzyme (sEH) is one of the most promising and emerging targets to develop drugs for multiple disease indications, including hypertension, diabetes, stroke, dyslipidemia, pain, and etc. Most inhibitor scaffolds have a urea or amide moiety to mimic the active-site transition state. In this regard, we developed a series of amide sEH inhibitors with a pyrimidin-2-ol ring as a new secondary pharmacophore, which was subjected to in vitro evaluation. Compound 4w (4-chloro-N-(4-(6-(4-chlorophenyl)-2-hydroxypyrimidin-4-...
Source: Chemistry and Biodiversity - September 24, 2022 Category: Biochemistry Authors: Leila Hejazi Ebrahim Ebadi Zeynab Fakhar Maryam Nazari Elham Rezaee Sayyed Abbas Tabatabai Source Type: research
