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Total 1283 results found since Jan 2013.

Na ïve bayes classifier assisted automated detection of cerebral microbleeds in SWI brain images
Biochem Cell Biol. 2023 Aug 28. doi: 10.1139/bcb-2023-0156. Online ahead of print.ABSTRACTCerebral Microbleeds (CMBs) in the brain are the essential indicators of critical brain disorders such as dementia and ischemic stroke. Generally, CMBs are detected manually by experts which is an exhaustive task with limited productivity. Since, CMBs have complex morphological nature, so manual detection is prone to errors. This paper presents a machine learning-based automated Cerebral Microbleeds detection technique in the brain SWI scans based on statistical feature extraction and classification. The proposed method consists of th...
Source: Biochemistry and Cell Biology - August 28, 2023 Category: Biochemistry Authors: Tayyab Ateeq Zaid Bin Faheem Mohamed Ghoneimy Dr Jehad Ali PhD Computer Engineering Yang Li Abdullah Baz Source Type: research

Exosomes from circRNA-Ptpn4 can modify ADSC treatment and repair nerve damage caused by cerebral infarction by shifting microglial M1/M2 polarization
This study showed that exosomes from hypoxia pretreatment of ADSCs had significant effects in promoting functional recovery following in vivo MCAO, through suppressed inflammatory factor expression, and shifting the microglial from M1 to M2 polarization activation. The results showed that circRNA-Ptpn4 was highly expressed during hypoxia pretreatment of ADSCs exosomes. Exosomes from circ-Ptpn4-modified ADSCs had a greater ability to promote functional recovery. The circ-Ptpn4 delivered from ADSC exosomes induced microglia/macrophage polarization from M1 to M2 by suppressing miR-153-3p and enhancing Nrf2 expressions. Taken ...
Source: Molecular and Cellular Biochemistry - August 26, 2023 Category: Biochemistry Authors: Fei Wang Mei Jiang Yongbin Chi Gang Huang Mingming Jin Source Type: research

Recent advances in the structure and activation mechanisms of metabolite-releasing Pannexin 1 channels
Biochem Soc Trans. 2023 Aug 25:BST20230038. doi: 10.1042/BST20230038. Online ahead of print.ABSTRACTPannexin 1 (PANX1) is a widely expressed large-pore ion channel located in the plasma membrane of almost all vertebrate cells. It possesses a unique ability to act as a conduit for both inorganic ions (e.g. potassium or chloride) and bioactive metabolites (e.g. ATP or glutamate), thereby activating varying signaling pathways in an autocrine or paracrine manner. Given its crucial role in cell-cell interactions, the activity of PANX1 has been implicated in maintaining homeostasis of cardiovascular, immune, and nervous systems....
Source: Biochemical Society Transactions - August 25, 2023 Category: Biochemistry Authors: Yi-Ling Wu Ai-Hsing Yang Yu-Hsin Chiu Source Type: research

Calycosin attenuates the inflammatory damage of microglia induced by oxygen and glucose deprivation through the HMGB1/TLR4/NF- κB signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Aug 1. doi: 10.3724/abbs.2023125. Online ahead of print.ABSTRACTStroke seriously threatens human life and health worldwide, but only very few effective stroke medicines are currently available. Our previous studies have indicated that the phytoestrogen calycosin exerts neuroprotective effects in cerebral ischemia and reperfusion injury rats. Therefore, the objective of this study is to further explore the protective effect of calycosin on inflammatory injury in microglia after oxygen-glucose deprivation/reoxygenation (OGD/R) and to clarify whether its protective effect is related t...
Source: Acta Biochimica et Biophysica Sinica - August 2, 2023 Category: Biochemistry Authors: Xiang Li Xin Yang Huiling Lu Wenbo Wang Le Cai Jian Chen Yong Wang Source Type: research

Synthesis and neuroprotective effects of new genipin derivatives against glutamate-induced oxidative damage
Fitoterapia. 2023 Jul 19:105616. doi: 10.1016/j.fitote.2023.105616. Online ahead of print.ABSTRACTGlutamate-induced oxidative stress is well-known to play a crucial role in the development of neurodegenerative diseases, such as stroke. Genipin, a natural iridoid compound, has demonstrated potential neuroprotective properties but is unstable in physiological conditions. The present study aimed to develop new derivatives of genipin that exhibit improved stability and activity for the treatment of stroke. Nineteen new derivatives were thus designed and synthesized. Their neuroprotective effect against glutamate-induced injury...
Source: Fitoterapia - July 21, 2023 Category: Biochemistry Authors: Liping Luo Dehuai Li Xiaojia Xu Qi Jia Zhiyin Li Ruilong Xu Zhenyu Chen Yu Zhao Source Type: research

Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature
We describe a case of suspected altered apixaban disposition in a patient with an upper gastrointestinal cancer resection treated with apixaban for non-valvular atrial fibrillation. Diagnosis of ischemic stroke for left hemiparesis was confirmed due to recent emergence of a hypodense area in the posterior capsular nucleus of ischemic reference in a context of binuclear capsular lacunar lesions. Thus, apixaban underexposure was suspected from anamnestic data and oral anticoagulation was switched to parenteral at the next scheduled dose for stroke recurrence. Before switching apixaban pharmacokinetic analysis was performed a...
Source: Clinical Biochemistry - July 14, 2023 Category: Biochemistry Authors: Giammarco Baiardi Alessia Cafaro Manuela Stella Michela Cameran Caviglia Maria Gabriella Poeta Giuliana Cangemi Francesca Mattioli Source Type: research

Altered plasma levels of apixaban in major gastrointestinal tract surgery: a case report and review of the literature
We describe a case of suspected altered apixaban disposition in a patient with an upper gastrointestinal cancer resection treated with apixaban for non-valvular atrial fibrillation. Diagnosis of ischemic stroke for left hemiparesis was confirmed due to recent emergence of a hypodense area in the posterior capsular nucleus of ischemic reference in a context of binuclear capsular lacunar lesions. Thus, apixaban underexposure was suspected from anamnestic data and oral anticoagulation was switched to parenteral at the next scheduled dose for stroke recurrence. Before switching apixaban pharmacokinetic analysis was performed a...
Source: Clinical Biochemistry - July 14, 2023 Category: Biochemistry Authors: Giammarco Baiardi Alessia Cafaro Manuela Stella Michela Cameran Caviglia Maria Gabriella Poeta Giuliana Cangemi Francesca Mattioli Source Type: research

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