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Specialty: Biochemistry
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Total 1283 results found since Jan 2013.
Synthesis, Docking Study and Biological Evaluation of Amide-Based Soluble Epoxide Hydrolase Inhibitors with Novel Secondary Pharmacophore of Pyrimidin-2-ol
Chem Biodivers. 2022 Sep 24. doi: 10.1002/cbdv.202200231. Online ahead of print.ABSTRACTSoluble epoxide hydrolase enzyme (sEH) is one of the most promising and emerging targets to develop drugs for multiple disease indications, including hypertension, diabetes, stroke, dyslipidemia, pain, and etc. Most inhibitor scaffolds have a urea or amide moiety to mimic the active-site transition state. In this regard, we developed a series of amide sEH inhibitors with a pyrimidin-2-ol ring as a new secondary pharmacophore, which was subjected to in vitro evaluation. Compound 4w (4-chloro-N-(4-(6-(4-chlorophenyl)-2-hydroxypyrimidin-4-...
Source: Chemistry and Biodiversity - September 24, 2022 Category: Biochemistry Authors: Leila Hejazi Ebrahim Ebadi Zeynab Fakhar Maryam Nazari Elham Rezaee Sayyed Abbas Tabatabai Source Type: research
independent origin for M.3243A & gt;G mitochondrial mutation in three venezuelan cases of melas syndrome
Clin Biochem. 2022 Sep 18:S0009-9120(22)00221-1. doi: 10.1016/j.clinbiochem.2022.09.007. Online ahead of print.ABSTRACTMitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a multisystem and progressive neurodegenerative mitochondrial disease, caused by point nucleotide changes in the mtDNA where 80% of cases have the mutation m.3243A>G in the MT-TL1 gene. In this work, we described the clinical, biochemical and molecular analysis of three Venezuelan patients affected with MELAS syndrome. All cases showed lactic acidosis, cortical cerebral atrophy on magnetic resonance imaging and ...
Source: Clinical Biochemistry - September 21, 2022 Category: Biochemistry Authors: Ingrid Florez Irune Pirrone Liliana Casique Carmen Luisa Dom ínguez Antonieta Mahfoud Tania Rodr íguez Daniel Rodr íguez Marisel De Lucca Jos é Luis Ramírez Source Type: research
EndMT-derived mesenchymal stem cells: a new therapeutic target to atherosclerosis treatment
Mol Cell Biochem. 2022 Sep 9. doi: 10.1007/s11010-022-04544-8. Online ahead of print.ABSTRACTCardiovascular diseases, such as coronary artery disease and stroke, are the main threats to human health worldwide. Atherosclerosis, a chronic inflammatory disorder, plays a role as an initiator of all of the above-mentioned diseases. Cell therapy for diseases has attracted widespread attention. Mesenchymal stem cells (MSCs) are a type of stem cell that still exist in adults and have the characteristics of self-renewal ability, pluripotent differentiation potential, immunomodulation, tissue regeneration, anti-inflammation and low ...
Source: Molecular and Cellular Biochemistry - September 9, 2022 Category: Biochemistry Authors: Xiaofan Zhang Zhong Ren Zhisheng Jiang Source Type: research
Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury
Biochem Soc Trans. 2022 Sep 6:BST20220446. doi: 10.1042/BST20220446. Online ahead of print.ABSTRACTIschemic stroke affects over 77 million people annually around the globe. Due to the blockage of a blood vessel caused by a stroke, brain tissue becomes ischemic. While prompt restoration of blood flow is necessary to save brain tissue, it also causes reperfusion injury. Mitochondria play a crucial role in early ischemia-reperfusion injury due to the generation of reactive oxygen species (ROS). During ischemia, mitochondria sense energy depletion and futilely attempt to up-regulate energy production. When reperfusion occurs, ...
Source: Biochemical Society Transactions - September 6, 2022 Category: Biochemistry Authors: Paul T Morse Junmei Wan Jamie Bell Icksoo Lee Dennis J Goebel Moh H Malek Thomas H Sanderson Maik H üttemann Source Type: research
Therapeutic effect of fastigial nucleus stimulation is mediated by the microRNA-182 & amp; microRNA-382/BDNF signaling pathways in the treatment of post-stroke depression
In conclusion, FN stimulation increases the expression of BDNF via down-regulating the expression of miR-382/miR-182, thus exhibiting a positive effect in the management of PSD.PMID:36030655 | DOI:10.1016/j.bbrc.2022.05.038
Source: Biochemical and Biophysical Research communications - August 28, 2022 Category: Biochemistry Authors: Zhuang Zhang Dong-Jian Xia An-Ding Xu Source Type: research
Phytochemicals from < em > Calophyllum canum < /em > Hook f. ex T. Anderson and their neuroprotective effects
Nat Prod Res. 2022 Aug 23:1-6. doi: 10.1080/14786419.2022.2116021. Online ahead of print.ABSTRACTPrevious phytochemical investigations reported that Calophyllum spp have biosynthesized a wide range of bioactive phenolics such as xanthones and coumarins. The phytochemical study conducted on the stem bark of C. canum has led to the isolation of eight trioxygenated xanthones namely: 5-methoxytrapezifolixanthone (1), 5-methoxyananixanthone (2), caloxanthone C (3), 1,5-dihydroxy-3-methoxy-4-isoprenylxanthone (4), 6-deoxyisojacareubin (5), euxanthone (6), trapezifolixanthone (7), ananixanthone (8), together with three common tri...
Source: Natural Product Research - August 23, 2022 Category: Biochemistry Authors: Mas Atikah Lizazman Vivien Yi Mian Jong PinFen Chua William K Lim Thiruventhan Karunakaran Source Type: research
PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells
Biochem Biophys Res Commun. 2022 Jul 19;623:133-139. doi: 10.1016/j.bbrc.2022.07.055. Online ahead of print.ABSTRACTE type prostanoid 4 (EP4) receptors and their signaling pathways have been implicated in the development and malignant transformation of colorectal cancer. We herein demonstrated that the mono(ADP-ribosyl)ation of histone deacetylase (HDAC)1 and HDAC2 by poly(ADP-ribose) polymerase 14 (PARP14) may be required to induce the expression of EP4 receptors. The suppression of PARP14 activity by siRNA and/or its inhibitors reduced the mRNA expression of EP4 receptors. Thus, the expression of their proteins to approx...
Source: Biochemical and Biophysical Research communications - August 1, 2022 Category: Biochemistry Authors: Masato Mashimo Asuka Shimizu Aimi Mori Ayaka Hamaguchi Keijo Fukushima Naofumi Seira Takeshi Fujii Hiromichi Fujino Source Type: research
