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Specialty: Biochemistry

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Total 1283 results found since Jan 2013.

Feasibility of Assessment of Conjunctival Microvascular Hemodynamics in Unilateral Ischemic Stroke
Publication date: Available online 24 April 2015 Source:Microvascular Research Author(s): Ali Kord Valeshabad , Justin Wanek , Faisal Mukarram , Ruth Zelkha , Fernando D. Testai , Mahnaz Shahidi Since the internal carotid artery supplies blood to both the eye and the brain, ocular microvascular hemodynamics can be altered due to ischemic stroke. The purpose of the current study was to establish the feasibility of conjunctival microcirculation imaging for detection of inter-ocular differences in microvascular hemodynamics in subjects with unilateral ischemic stroke. Conjunctival microcirculation imaging was performed in b...
Source: Microvascular Research - April 25, 2015 Category: Biochemistry Source Type: research

Stroke injury, cognitive impairment and vascular dementia.
This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. PMID: 26806700 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - January 21, 2016 Category: Biochemistry Authors: Kalaria RN, Akinyemi R, Ihara M Tags: Biochim Biophys Acta Source Type: research

IL-23 and IL-17 in Acute Ischemic Stroke: Correlation with Stroke Scales and Prognostic Value
CONCLUSION: IL-23 and IL-17 increase after stroke, but had no sufficient discriminative capacity to be of clinical use as outcome stroke predictors.PMID:34496287 | DOI:10.1016/j.clinbiochem.2021.09.003
Source: Clinical Biochemistry - September 8, 2021 Category: Biochemistry Authors: Fabiane Neiva Backes Andressa de Souza Marino Muxfeldt Bianchin Source Type: research

Heat Shock Protein A12A Encodes a Novel Prosurvival Pathway during Ischaemic Stroke.
This study investigated the effects of HSPA12A on ischaemic stroke in mice. Ischaemic stroke was induced by left middle cerebral artery occlusion for 1 h followed by blood reperfusion. We observed that HSPA12A was highly expressed in brain neurons, and neuronal HSPA12A expression was downregulated by ischaemic stroke and stroke-associated risk factors (aging, obesity and hyperglycaemia). To investigate the functional requirement of HSPA12A in protecting ischaemic brain injury, HSPA12A knockout mice (Hspa12a-/-) were generated. Hspa12a-/- mice exhibited an enlarged infarct volume and aggravated neurological deficits compare...
Source: Biochimica et Biophysica Acta - March 9, 2018 Category: Biochemistry Authors: Mao Y, Kong Q, Li R, Zhang X, Gui Y, Li Y, Li C, Zhao Y, Liu L, Ding Z Tags: Biochim Biophys Acta Source Type: research

The prognostic value of serum pregnancy-associated plasma protein A, S100 and high sensitivity C-reactive protein in acute ischemic stroke patients without heparin administration.
CONCLUSION:: Serum PAPP-A, S100 and hs-CRP were associated with stroke severity or outcome after ischemic stroke and may offer complementary information, essential for clinical decision making. Serum PAPP-A showed a potential value for the evaluation of stroke clinically. PMID: 25117449 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - August 9, 2014 Category: Biochemistry Authors: Wang L, Jiang J, Du L, Zhang X, Wang C Tags: Clin Biochem Source Type: research

Association between trace elements in the environment and stroke risk: The reasons for geographic and racial differences in stroke (REGARDS) study
Publication date: Available online 7 April 2017 Source:Journal of Trace Elements in Medicine and Biology Author(s): Peter D. Merrill, Steve B. Ampah, Ka He, Nicole J. Rembert, John Brockman, Dawn Kleindorfer, Leslie A. McClure The disparities in stroke mortality between blacks and whites, as well as the increased stroke mortality in the “stroke belt” have long been noted. The reasons for these disparities have yet to be fully explained. The association between trace element status and cardiovascular diseases, including stroke, has been suggested as a possible contributor to the disparities in stroke mortality but has ...
Source: Journal of Trace Elements in Medicine and Biology - April 10, 2017 Category: Biochemistry Source Type: research

Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke
In this study, we aimed to investigate the underlying mechanism. Sprague-Dawley rats were randomly divided into the sham, ischemic stroke, ischemic stroke + VNS, ischemic stroke + VNS + lentivirus (LV)-TLR4 and ischemic stroke + VNS + LV-CON groups. LV was injected into the lateral ventricles of the rats 14 days before ischemic stroke surgery, and VNS was administered after 30 min of occlusion. We assessed the infarct volume, neurological scores, the TLR4/MyD88/NF-κB protein level and microglia polarization after 3 days of reperfusion. Our results revealed that VNS can promote M2 microglia polarization and inhibit M1 micr...
Source: Biochemical and Biophysical Research communications - September 10, 2021 Category: Biochemistry Authors: Liping Zhang Yilin Liu Sanrong Wang Lu Long Qianwen Zang Jingxi Ma Lehua Yu Gongwei Jia Source Type: research

Quantitative Clinical Proteomic Study of Autopsied Human Infarcted Brain Specimens to Elucidate the Deregulated Pathways in Ischemic Stroke Pathology.
Abstract Ischemic stroke, still lacking an effective neuroprotective therapy is the third leading cause of global mortality and morbidity. Here, we have applied an 8-plex iTRAQ-based 2D-LC-MS/MS strategy to study the commonly regulated infarct proteome from three different brain regions (putamen, thalamus and the parietal lobe) of female Japanese patients. Infarcts were compared with age-, post-mortem interval- and location-matched control specimens. The iTRAQ experiment confidently identified 1520 proteins with 0.1% false discovery rate. Bioinformatic data mining and immunochemical validation of pivotal perturbed...
Source: Journal of Proteomics - September 2, 2013 Category: Biochemistry Authors: Datta A, Akatsu H, Heese K, Sze SK Tags: J Proteomics Source Type: research

The Metal and Metalloprotein Profile of Human Plasma as Biomarkers for Stroke Diagnosis
Publication date: Available online 7 April 2017 Source:Journal of Trace Elements in Medicine and Biology Author(s): Keaton S. Nahan, Kyle B. Walsh, Opeolu Adeoye, Julio A. Landero-Figueroa Stroke, a major cause of disability and mortality, affects someone in the United States every 40seconds. Stroke biomarkers, including those that could be used as a blood test for diagnosis of stroke, have been particularly elusive. We performed a double blind study to identify human plasma biomarkers for the diagnosis of stroke, including acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). We utilized a three-track approach ...
Source: Journal of Trace Elements in Medicine and Biology - April 10, 2017 Category: Biochemistry Source Type: research

Stroke in women: Risk factors and clinical biomarkers
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - May 12, 2017 Category: Biochemistry Authors: Hamed Mirzaei Tags: Article Source Type: research

Dietary and blood selenium are inversely associated with the prevalence of stroke among Inuit in Canada
In conclusion, blood and dietary selenium are reversely associated with the prevalence of stroke in Inuit, which follows an L-shaped relationship. Whether this relationship applies to other population needs further investigation.
Source: Journal of Trace Elements in Medicine and Biology - September 7, 2017 Category: Biochemistry Source Type: research

Former antiplatelet drug administration and consequences of intravenous thrombolysis in acute ischemic stroke.
CONCLUSION: Based on the results of this study, patients with acute ischemic stroke and history of taking antiplatelet drugs have poor outcome following administration of standard dose of tPA. PMID: 31356199 [PubMed - as supplied by publisher]
Source: Human Antibodies - July 31, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

The Nutraceutical Potential of Omega-3 Alpha-Linolenic Acid in Reducing the Consequences of Stroke.
Abstract Stroke is a worldwide major cause of mortality and morbidity. Preclinical studies have identified over 1000 molecules with brain-protective properties. More than 200 clinical trials have evaluated neuroprotective candidates for ischemic stroke yet, to date almost all failed, leading to a re-analysis of treatment strategies against stroke. An emerging view is to seek combinatory therapy, or discovering molecules able to stimulate multiple protective and regenerative mechanisms. A pertinent experimental approach to identify such candidates is the study of brain preconditioning, which refers to how the brain...
Source: Biochimie - June 16, 2015 Category: Biochemistry Authors: Blondeau N Tags: Biochimie Source Type: research