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Specialty: Biochemistry

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Total 1283 results found since Jan 2013.

Blood ‐based protein biomarkers for stroke differentiation: A systematic review
Computed tomography (CT) scan is the mainstay for diagnosis of stroke; but the facility of CT scan is not easily available. A blood‐based biomarker approach is required to distinguish ischemic stroke (IS) from hemorrhagic stroke (HS) in pre‐hospital settings.To conduct a systematic review of diagnostic utility of blood biomarkers for differential diagnosis of stroke.A comprehensive literature search was carried out till March 7, 2017 in PubMed, Cochrane, Medline, OVID, and Google Scholar databases. Methodological quality of each study was assessed using the modified Quality Assessment of Diagnostic Accuracy Studies que...
Source: Proteomics. Clinical Applications - May 29, 2017 Category: Biochemistry Authors: Shubham Misra, Amit Kumar, Pradeep Kumar, Arun K Yadav, Dheeraj Mohania, Awadh K Pandit, Kameshwar Prasad, Deepti Vibha Tags: Review Source Type: research

Pyroptosis of HUVECs can be induced by heat stroke.
Abstract Heat stroke is a serious pathological condition with high mortality. Vascular endothelial cell injury is a key feature in the pathogenesis of heat stroke, but the specific pathophysiological process whereby this occurs is still unclear. Currently, relevant studies are primarily based upon examination of apoptosis. Recently, pyroptosis, a new form of inflammation-related programmed cell death, was also demonstrated to be involved in heat stroke pathophysiology. Herein, we present evidence that vascular endothelial cell pyroptosis can be induced by heat stress in a time- and temperature-dependent manner. Fu...
Source: Biochemical and Biophysical Research communications - November 22, 2018 Category: Biochemistry Authors: Pei Y, Geng Y, Su L Tags: Biochem Biophys Res Commun Source Type: research

Distinct proteomic profiles in monozygotic twins discordant for ischaemic stroke.
Abstract Stroke is a common disorder with significant morbidity and mortality, and complex aetiology involving both environmental and genetic risk factors. Although some of the major risk factors for stoke, such as smoking and hypertension, are well-documented, the underlying genetic and detailed molecular mechanisms remain elusive. Exploring the relevant biochemical pathways may contribute to the clinical diagnosis of stroke and shed light on its aetiology. A comparative proteomic analysis of blood serum of a pair of monozygotic (MZ) twins discordant for ischaemic stroke (IS) was performed using a label-free quan...
Source: Molecular and Cellular Biochemistry - January 29, 2019 Category: Biochemistry Authors: Vadgama N, Lamont D, Hardy J, Nasir J, Lovering RC Tags: Mol Cell Biochem Source Type: research

GRM7 polymorphisms are not associated with ischemic stroke in Iranian population.
Conclusion: Consequently, the assessed GRM7 variants are not implicated in risk of ischemic stroke in Iranian population. PMID: 32011203 [PubMed - as supplied by publisher]
Source: Nucleosides, Nucleotides and Nucleic Acids - February 7, 2020 Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research

An Overview on Stroke: Mechanism, in vivo Experimental Models Thereof and Neuroprotective Agents.
CONCLUSION: The injury mechanism, available encouraging medicaments thereof, and outcomes of natural and modern medicines for ischemia have been summarised. In spite of available therapeutic agents (thrombolytics, calcium channel blockers, NMDA receptor antagonists and antioxidants), there is a need of an ideal drug for stroke. PMID: 32552641 [PubMed - as supplied by publisher]
Source: Current Protein and Peptide Science - June 16, 2020 Category: Biochemistry Authors: Khan MM, Badruddeen, Mujahid M, Akhtar J, Khan MI, Ahmad U Tags: Curr Protein Pept Sci Source Type: research

Ischemic stroke, obesity, and the anti ‐inflammatory role of melatonin
AbstractObesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it. Pathologies following these conditions are associated with systemic and local inflammation. Moreover, there is increasing evidence that the susceptibility for ischemic brain damage increases substantially in experimental models of ischemic stroke with concomitant obesity. Herein, we explore the proinflammatory events that occur during ischemic stroke and obesity, and we discuss the influence of obesity on the inflammatory response and cerebral damage outcomes in experimental models of brain ischemia. In addition, because melat...
Source: BioFactors - November 2, 2020 Category: Biochemistry Authors: Nuttapong Yawoot, Piyarat Govitrapong, Chainarong Tocharus, Jiraporn Tocharus Tags: Review Article Source Type: research

Increase of Cry 1 expression is a common phenomenon of the disturbed circadian clock in ischemic stroke and opioid addiction
Biochem Biophys Res Commun. 2021 Apr 21;558:8-13. doi: 10.1016/j.bbrc.2021.04.053. Online ahead of print.ABSTRACTIncreasing evidences suggest the involvement of disrupted circadian clock in various pathologies including stroke and substance abuse. Here we took an attempt to do a comparative study on the regulation of circadian clock gene expression under two pathological circumstances - Opioid addiction and Ischemic stroke in the same cell line model (human neuroblastoma SH-SY5Y cells). To mimic in vivo ischemic stroke condition cells were placed in a hypoxia chamber and incubated for 10 h in balanced salt solution lacking...
Source: Biochemical and Biophysical Research communications - April 24, 2021 Category: Biochemistry Authors: Kaninika Roy Daytee Maji Ishani Deb Source Type: research

Combined Treatment of Bone Marrow Mesenchymal Stem Cells and Fasudil Promotes Neurovascular Remodeling and Neurological Function Recovery in Ischemic Stroke
Appl Biochem Biotechnol. 2021 Sep 20. doi: 10.1007/s12010-021-03679-6. Online ahead of print.ABSTRACTStroke remains a highly deadly and disabling disease with limited treatment tragedies due to the limitations of available treatments; novel therapies for stroke are needed. In this article, the synergistic results of dual bone marrow mesenchymal stem cells (BMSC) and fasudil treatment in rat models of ischemic stroke still require further identification. Sprague-Dawley rats were used to construct the middle cerebral artery, occlusion models. BMSCs were incubated with fasudil, and MTT was performed to evaluate cell prolifera...
Source: Applied Biochemistry and Biotechnology - September 20, 2021 Category: Biochemistry Authors: Qian Wang Shu-Fang Zhao Xia Xiao Ya-Nan Liu Xiu-Li Wang Yun-Xia Du Source Type: research

Functional reconstruction of the impaired cortex and motor function by hMGEOs transplantation in stroke
Biochem Biophys Res Commun. 2023 Jun 3;671:87-95. doi: 10.1016/j.bbrc.2023.06.010. Online ahead of print.ABSTRACTStroke is the leading cause of death and long-term disability worldwide. But treatments are not available to promote functional recovery, and efficient therapies need to be investigated. Stem cell-based therapies hold great promise as potential technologies to restore function in brain disorders. Loss of GABAergic interneurons after stroke may result in sensorimotor defects. Here, by transplanting human brain organoids resembling the MGE domain (human MGE organoids, hMGEOs) derived from human induced pluripotent...
Source: Biochemical and Biophysical Research communications - June 10, 2023 Category: Biochemistry Authors: Shi-Ying Cao Meng-Dan Tao Shu-Ning Lou Di Yang Yu-Hui Lin Hai-Yin Wu Lei Chang Chun-Xia Luo Yun Xu Yan Liu Dong-Ya Zhu Source Type: research