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Specialty: Biochemistry
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Total 1283 results found since Jan 2013.
Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population
Publication date: Available online 16 December 2017 Source:Mitochondrion Author(s): Miriam Umbria, Amanda Ramos, Jennifer Caner, Tomás Vega, José Eugenio Lozano, Cristina Santos, Maria Pilar Aluja There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p=0.001; OR=2...
Source: Mitochondrion - December 17, 2017 Category: Biochemistry Source Type: research
A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS)
Publication date: Available online 19 February 2018 Source:Mitochondrion Author(s): Karien Esterhuizen, J. Zander Lindeque, Shayne Mason, Francois H. van der Westhuizen, Anu Suomalainen, Anna H. Hakonen, Christopher J. Carroll, Richard J. Rodenburg, Paul B. de Laat, Mirian C.H. Janssen, Jan A.M. Smeitink, Roan Louw We used a comprehensive metabolomics approach to study the altered urinary metabolome of two mitochondrial myopathy, encephalopathy lactic acidosis and stroke like episodes (MELAS) cohorts carrying the m.3243A>G mutation. The first cohort were used in an exploratory phase, identifying 36 metabolites that...
Source: Mitochondrion - February 20, 2018 Category: Biochemistry Source Type: research
Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population
Publication date: Available online 16 December 2017Source: MitochondrionAuthor(s): Miriam Umbria, Amanda Ramos, Jennifer Caner, Tomás Vega, José Eugenio Lozano, Cristina Santos, Maria Pilar AlujaAbstractThere are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors.Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p =&...
Source: Mitochondrion - July 5, 2018 Category: Biochemistry Source Type: research
A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS)
Publication date: Available online 19 February 2018Source: MitochondrionAuthor(s): Karien Esterhuizen, J. Zander Lindeque, Shayne Mason, Francois H. van der Westhuizen, Anu Suomalainen, Anna H. Hakonen, Christopher J. Carroll, Richard J. Rodenburg, Paul B. de Laat, Mirian C.H. Janssen, Jan A.M. Smeitink, Roan LouwAbstractWe used a comprehensive metabolomics approach to study the altered urinary metabolome of two mitochondrial myopathy, encephalopathy lactic acidosis and stroke like episodes (MELAS) cohorts carrying the m.3243A>G mutation.The first cohort were used in an exploratory phase, identifying 36 metabolites that we...
Source: Mitochondrion - July 11, 2018 Category: Biochemistry Source Type: research
Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population
Publication date: Available online 16 December 2017Source: MitochondrionAuthor(s): Miriam Umbria, Amanda Ramos, Jennifer Caner, Tomás Vega, José Eugenio Lozano, Cristina Santos, Maria Pilar AlujaAbstractThere are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors.Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p =&...
Source: Mitochondrion - July 11, 2018 Category: Biochemistry Source Type: research
Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sj ögren's syndrome.
Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sjögren's syndrome.
Amino Acids. 2019 Mar 12;:
Authors: Igarashi K, Uemura T, Kashiwagi K
Abstract
It was found recently that acrolein (CH2=CH-CHO), mainly produced from spermine, is more toxic than ROS (reactive oxygen species, O 2 -· , H2O2, and ·OH). In this review, we describe how the seriousness of brain infarction, dementia, renal failure, and Sjӧgren's syndrome is correlated with acrolein. In brain infarction and dementia, it was possible to identify incipient patients with high sensitivity an...
Source: Amino Acids - March 11, 2019 Category: Biochemistry Authors: Igarashi K, Uemura T, Kashiwagi K Tags: Amino Acids Source Type: research
Dendrimer Grafted Albumin Nanoparticles for the Treatment of Post Cerebral Stroke Damages: A Proof of Concept Study
Publication date: Available online 3 September 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Deepak Pradhan, Vishakha Tambe, Nidhi Raval, Piyush Gondalia, Pallab Bhattacharya, Kiran Kalia, Rakesh K. TekadeAbstractStroke is the second largest disease of mortality. The biggest hurdle in designing effective brain drug delivery systems is offered by the blood-brain barrier (BBB), which is highly impermeable to many drugs. Albumin nanoparticles (NP) have gained attention due to their multiple ligand binding sites and long circulatory half-life. Citicoline (CIT) is reported to enhance the acetylcholine secretion i...
Source: Colloids and Surfaces B: Biointerfaces - September 10, 2019 Category: Biochemistry Source Type: research
Cerebrospinal fluid ATP as a potential biomarker in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS)
Publication date: Available online 19 November 2019Source: MitochondrionAuthor(s): Takamasa Nukui, Atsushi Matsui, Hideki Niimi, Mamoru Yamamoto, Noriyuki Mastuda, Jin-Lan Piao, Kyo Noguchi, Isao Kitajima, Yuji NakastujiAbstractMitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is caused by defective oxidative phosphorylation in the cerebral parenchyma, cerebral blood vessels, and leptomeningeal tissue. Although increased serum and cerebrospinal fluid (CSF) lactate level has been used as a diagnostic biomarker in patients with MELAS, no biomarkers reflecting disease activity exist. Since we hav...
Source: Mitochondrion - November 20, 2019 Category: Biochemistry Source Type: research
Association of vaspin gene expression and its serum level on the risk of ischemic stroke in type 2 diabetic Egyptian patients: Prospective case ‐control study
In conclusion, the higher levels of serum vaspin and vaspin expression levels in T2DM emphasizes the pivotal role of vaspin serum level and expression in the progression of metabolic and glucose abnormalities, thus, they could be used as biomarkers of IS.
Source: Biotechnology and Applied Biochemistry - January 13, 2021 Category: Biochemistry Authors: Nearmeen M. Rashad,
Hanan S. Ahmed,
Waleed M. Reda Ashour,
Mohammed S. Yousef Tags: Original Article Source Type: research
LncRNA MEG3 inhibits the proliferation of neural stem cells after ischemic stroke via the miR-493-5P/MIF axis
Conclusion MEG3 inhibits NSC proliferation of after IS via positive regulation of miR-493-5p and potential subsequent downregulation of MIF.PMID:34273844 | DOI:10.1016/j.bbrc.2021.06.033
Source: Biochemical and Biophysical Research communications - July 17, 2021 Category: Biochemistry Authors: Fan Zhao Yu Xing Pu Jiang Lai Hu Shixiong Deng Source Type: research
Association of SERPINE1 rs1799889 polymorphism with arterial ischemic stroke in children: a systematic review and meta-analysis
This study suggested that SERPINE1 rs1799889 polymorphism might be not related to etiology of AIS in children. Moreover, well-designed, large-scale and multicenter clinical studies are required to improve and validate these results.Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1966798 .PMID:34429017 | DOI:10.1080/15257770.2021.1966798
Source: Nucleosides, Nucleotides and Nucleic Acids - August 25, 2021 Category: Biochemistry Authors: Reza Bahrami Seyed Alireza Dastgheib Hamid Mirjalili Sepideh Setayesh Seyed Hossein Shaker Seyed Reza Mirjalili Mahmood Noorishadkam Hossein Neamatzadeh Source Type: research
