Mitochondrial migraine; a prevalence, impact and treatment efficacy cohort study
Publication date: Available online 25 May 2020Source: MitochondrionAuthor(s): Laurie H Tiehuis, Saskia Koene, Christiaan GJ Saris, Mirian CH Janssen (Source: Mitochondrion)
Source: Mitochondrion - May 26, 2020 Category: Biochemistry Source Type: research

Modulation of host mitochondrial dynamics during bacterial infection
Publication date: Available online 26 May 2020Source: MitochondrionAuthor(s): Shaziya Khan, Desh Raj, Kritika Jaiswal, Amit Lahiri (Source: Mitochondrion)
Source: Mitochondrion - May 26, 2020 Category: Biochemistry Source Type: research

The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit
Publication date: Available online 26 May 2020Source: MitochondrionAuthor(s): Yura Do, Shigeru Matsuda, Teppei Inatomi, Kazuto Nakada, Takehiro Yasukawa, Dongchon Kang (Source: Mitochondrion)
Source: Mitochondrion - May 26, 2020 Category: Biochemistry Source Type: research

Chemical acetylation of mitochondrial transcription factor A occurs on specific lysine residues and affects its ability to change global DNA topology
Publication date: Available online 18 May 2020Source: MitochondrionAuthor(s): Yuan Fang, Masaru Akimoto, Kouta Mayanagi, Atsushi Hatano, Masaki Matsumoto, Shigeru Matsuda, Takehiro Yasukawa, Dongchon Kang (Source: Mitochondrion)
Source: Mitochondrion - May 20, 2020 Category: Biochemistry Source Type: research

MEF46 and MEF47 are novel specificity factors for RNA editing sites in mitochondrial nad transcripts
Publication date: Available online 18 May 2020Source: MitochondrionAuthor(s): Nadja Brehme, Franziska Glass, Anja Jörg, Mizuki Takenaka (Source: Mitochondrion)
Source: Mitochondrion - May 20, 2020 Category: Biochemistry Source Type: research

Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response
Publication date: Available online 18 May 2020Source: MitochondrionAuthor(s): Pedro Barreto, Rafael Miguez Couñago, Paulo Arruda (Source: Mitochondrion)
Source: Mitochondrion - May 18, 2020 Category: Biochemistry Source Type: research

Protein turnover rates in plant mitochondria
Publication date: Available online 5 May 2020Source: MitochondrionAuthor(s): Shaobai Huang, Lei Li, Jakob Petereit, A. Harvey Millar (Source: Mitochondrion)
Source: Mitochondrion - May 6, 2020 Category: Biochemistry Source Type: research

Novel p.P298L SURF1 mutation in thiamine deficient Leigh syndrome patients compromises cytochrome c oxidase activity
Publication date: Available online 4 May 2020Source: MitochondrionAuthor(s): Shalini Mani, G.R. Chandak, Keshav K. Singh, Rajender Singh, S. Narasimha Rao (Source: Mitochondrion)
Source: Mitochondrion - May 5, 2020 Category: Biochemistry Source Type: research

Differential contributions of sarcomere and mitochondria-related multigene variants to the endophenotype of hypertrophic cardiomyopathy
Publication date: Available online 4 May 2020Source: MitochondrionAuthor(s): Hyemoon Chung, Yoonjung Kim, Sun-Mi Cho, Ho-Joon Lee, Chul-Hwan Park, Jong-Youn Kim, Sang-Hak Lee, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Woo-Shik Kim, Bum-Kee Hong, Tae Hoon Kim, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi, Kyung-A Lee (Source: Mitochondrion)
Source: Mitochondrion - May 5, 2020 Category: Biochemistry Source Type: research

The Role of Mitochondrial-related Nuclear Genes in Age-related Common Disease
Publication date: Available online 30 April 2020Source: MitochondrionAuthor(s): Huanzheng Li, Jesse Slone, Taosheng Huang (Source: Mitochondrion)
Source: Mitochondrion - May 2, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: May 2020Source: Mitochondrion, Volume 52Author(s): (Source: Mitochondrion)
Source: Mitochondrion - April 30, 2020 Category: Biochemistry Source Type: research

The Oxidative Phosphorylation system of the mitochondria in plants
Publication date: Available online 22 April 2020Source: MitochondrionAuthor(s): Hans-Peter Braun (Source: Mitochondrion)
Source: Mitochondrion - April 23, 2020 Category: Biochemistry Source Type: research

Specificities of the plant mitochondrial translation apparatus
Publication date: Available online 22 April 2020Source: MitochondrionAuthor(s): Florent Waltz, Nicolas Corre, Yaser Hashem, Philippe Giegé (Source: Mitochondrion)
Source: Mitochondrion - April 23, 2020 Category: Biochemistry Source Type: research

Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers
Publication date: Available online 15 April 2020Source: MitochondrionAuthor(s): C. Silaidos, J. Grube, C. Muley, G.P. Eckert (Source: Mitochondrion)
Source: Mitochondrion - April 16, 2020 Category: Biochemistry Source Type: research

Molecular mechanism of mitochondrial respiratory chain assembly and its relation to mitochondrial diseases
Publication date: Available online 15 April 2020Source: MitochondrionAuthor(s): Soumyajit Mukherjee, Alok Ghosh (Source: Mitochondrion)
Source: Mitochondrion - April 16, 2020 Category: Biochemistry Source Type: research

Photosynthesis, respiration and growth: A carbon and energy balancing act for alternative oxidase
Publication date: May 2020Source: Mitochondrion, Volume 52Author(s): Greg C. Vanlerberghe, Keshav Dahal, Nicole A. Alber, Avesh Chadee (Source: Mitochondrion)
Source: Mitochondrion - April 14, 2020 Category: Biochemistry Source Type: research

Photosynthesis, Respiration and Growth:A Carbon and Energy Balancing Act for Alternative Oxidase
Publication date: Available online 9 April 2020Source: MitochondrionAuthor(s): Greg C. Vanlerberghe, Keshav Dahal, Nicole A. Alber, Avesh Chadee (Source: Mitochondrion)
Source: Mitochondrion - April 10, 2020 Category: Biochemistry Source Type: research

Mitochondrial bound hexokinase type I in normal and streptozotocin diabetic rat retina
Publication date: Available online 10 April 2020Source: MitochondrionAuthor(s): Gabriela Ramírez-Pérez, Gustavo Sánchez-Chávez, Rocío Salceda (Source: Mitochondrion)
Source: Mitochondrion - April 10, 2020 Category: Biochemistry Source Type: research

Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism
Publication date: Available online 8 April 2020Source: MitochondrionAuthor(s): Natalya I. Venediktova, Oleksandr V. Mashchenko, Eugeny Y. Talanov, Natalia V. Belosludtseva, Galina D. Mironova (Source: Mitochondrion)
Source: Mitochondrion - April 10, 2020 Category: Biochemistry Source Type: research

Citrate valve integrates mitochondria into photosynthetic metabolism
Publication date: Available online 8 April 2020Source: MitochondrionAuthor(s): Abir U. Igamberdiev (Source: Mitochondrion)
Source: Mitochondrion - April 10, 2020 Category: Biochemistry Source Type: research

Abnormal lncRNA CCAT1/microRNA-155/SIRT1 axis promoted inflammatory response and apoptosis of tubular epithelial cells in LPS caused acute kidney injury
Publication date: Available online 31 March 2020Source: MitochondrionAuthor(s): Shan Lu, Liu Dong, Xiao Jing, Cheng Gen-Yang, Liu Zhang-Suo, Zhao Zhan-Zheng (Source: Mitochondrion)
Source: Mitochondrion - April 1, 2020 Category: Biochemistry Source Type: research

Self-initiated lifestyle interventions lead to potential insight into an effective, alternative, non-surgical therapy for mitochondrial disease associated multiple symmetric lipomatosis
Publication date: Available online 29 March 2020Source: MitochondrionAuthor(s): Elizabeth Nadeau, Michelle M. Mezei, Mark Cresswell, Sida Zhao, Taryn Bosdet, Don D. Sin, Jordan A. Guenette, Isabelle Dupuis, Emily Allin, David C. Clarke, Andre Mattman (Source: Mitochondrion)
Source: Mitochondrion - March 30, 2020 Category: Biochemistry Source Type: research

Mitochondria in parasitic plants
Publication date: Available online 26 March 2020Source: MitochondrionAuthor(s): Gitte Petersen, Benjamin Anderson, Hans-Peter Braun, Etienne H. Meyer, Ian Max Møller (Source: Mitochondrion)
Source: Mitochondrion - March 26, 2020 Category: Biochemistry Source Type: research

Clinico-pathological significance of Drp1 dysregulation and its correlation to apoptosis in oral cancer patients
Publication date: May 2020Source: Mitochondrion, Volume 52Author(s): Aritri Ghosh, Kabita Chatterjee, Amit Roy Chowdhury, Ananya Barui (Source: Mitochondrion)
Source: Mitochondrion - March 17, 2020 Category: Biochemistry Source Type: research

Interchangeable parts: The evolutionarily dynamic tRNA population in plant mitochondria
Publication date: Available online 14 March 2020Source: MitochondrionAuthor(s): Jessica M. Warren, Daniel B. Sloan (Source: Mitochondrion)
Source: Mitochondrion - March 16, 2020 Category: Biochemistry Source Type: research

Role of mitochondrial DNA variants in the development of fragile X-associated tremor/ataxia syndrome
Publication date: Available online 12 March 2020Source: MitochondrionAuthor(s): Maria Isabel Alvarez-Mora, Cristina Santos, Lidia Carreño-Gago, Irene Madrigal, Maria Isabel Tejada, Francisco Martinez, Silvia Izquierdo-Alvarez, Elena Garcia-Arumi, Montserrat Mila, Laia Rodriguez-Revenga (Source: Mitochondrion)
Source: Mitochondrion - March 12, 2020 Category: Biochemistry Source Type: research

Chronic Marijuana Use Moderates the Correlations of Serum Cholesterol with Systemic Mitochondrial Function and Fluid Cognition
Publication date: Available online 10 March 2020Source: MitochondrionAuthor(s): Jun Panee, Viola Pomozi, Adrian A. Franke, Olivier Saux, Mariana Gerschenson (Source: Mitochondrion)
Source: Mitochondrion - March 11, 2020 Category: Biochemistry Source Type: research

Clinico-pathological significance of Drp1dysregulation and its correlation to apoptosis in oral cancer patients
Publication date: Available online 10 March 2020Source: MitochondrionAuthor(s): Aritri Ghosh, Kabita Chatterjee, Amit Roy Chowdhury, Ananya Barui (Source: Mitochondrion)
Source: Mitochondrion - March 11, 2020 Category: Biochemistry Source Type: research

Mitochondrial tRNA mutations in 887 Chinese Subjects with Hearing Loss
Publication date: Available online 10 March 2020Source: MitochondrionAuthor(s): Jing Zheng, Xiaohui Bai, Yun Xiao, Yanchun Ji, Feilong Meng, Maerhaba Aishanjiang, Yinglong Gao, Haibo Wang, Yong Fu, Min-Xin Guan (Source: Mitochondrion)
Source: Mitochondrion - March 11, 2020 Category: Biochemistry Source Type: research

Platelet mtDNA content and leukocyte count influence whole blood mtDNA content
Publication date: Available online 7 March 2020Source: MitochondrionAuthor(s): Hanjoo B. Shim, Omair Arshad, Izabella Gadawska, Hélène C.F. Côté, Anthony Y.Y. Hsieh (Source: Mitochondrion)
Source: Mitochondrion - March 7, 2020 Category: Biochemistry Source Type: research

Causes and consequences of mitochondrial proteome size variation in animals
Publication date: May 2020Source: Mitochondrion, Volume 52Author(s): Viraj Muthye, Dennis V. Lavrov (Source: Mitochondrion)
Source: Mitochondrion - March 7, 2020 Category: Biochemistry Source Type: research

Combination therapy with astaxanthin and epidermal neural crest stem cells improves motor impairments and activates mitochondrial biogenesis in a rat model of spinal cord injury
Publication date: Available online 6 March 2020Source: MitochondrionAuthor(s): Leila Mohaghegh Shalmani, Neda Valian, Safura Pournajaf, Fatemeh Abbaszadeh, Leila Dargahi, Masoumeh Jorjani (Source: Mitochondrion)
Source: Mitochondrion - March 7, 2020 Category: Biochemistry Source Type: research

Alpha lipoic acid and Vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats
Publication date: Available online 28 February 2020Source: MitochondrionAuthor(s): Hatice Eser Faki, Bunyamin Tras, Kamil Uney (Source: Mitochondrion)
Source: Mitochondrion - February 29, 2020 Category: Biochemistry Source Type: research

The ERMES (Endoplasmic Reticulum and Mitochondria Encounter Structures) mediated functions in fungi
Publication date: Available online 24 February 2020Source: MitochondrionAuthor(s): Deepika Kundu, Ritu Pasrija (Source: Mitochondrion)
Source: Mitochondrion - February 25, 2020 Category: Biochemistry Source Type: research

Causes and consequences of mitochondrial proteome size-variation in animals
Publication date: Available online 25 February 2020Source: MitochondrionAuthor(s): Viraj Muthye, Dennis V. Lavrov (Source: Mitochondrion)
Source: Mitochondrion - February 25, 2020 Category: Biochemistry Source Type: research

Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment
Publication date: Available online 22 February 2020Source: MitochondrionAuthor(s): Yuma Yamada, Yutaka Fukuda, Daisuke Sasaki, Minako Maruyama, Hideyoshi HarashimaAbstractThe delivery of nucleic acids targeting mutant mtDNA represent a potential strategy for addressing a variety of mitochondria-related diseases. We previously developed a MITO-Porter, a nano carrier that is capable of delivering nanoparticles of nucleic acids to mitochondria of human cells. Here, we report on an investigation of a series of nanoparticles formed with various poly cationic peptides that can release nucleic acids in response to a mitochondrial...
Source: Mitochondrion - February 24, 2020 Category: Biochemistry Source Type: research

Expanding the phenotype of mitochondrial disease: novel pathogenic variant in ISCA1 leading to instability of the iron-sulfur cluster in the protein
We report a patient carrying a novel pathogenic variant p.(Tyr101Cys) in ISCA1 leading to MMDS type 5. He initially presented a psychomotor regression with loss of gait and language skills and a tetrapyramidal spastic syndrome. Biochemical analysis of patient fibroblasts revealed impaired lipoic acid synthesis and decreased activities of complex I and II of respiratory chain. While ISCA1 is involved in mitochondrial machinery of iron-sulfur cluster biogenesis, these dysfunctions are secondary to impaired maturation of mitochondrial proteins containing the [4Fe-4S] clusters. Expression and purification of the human ISCA1 sh...
Source: Mitochondrion - February 23, 2020 Category: Biochemistry Source Type: research

Mitochondrial Dysfunction: An Emerging Link in the Pathophysiology of Polycystic Ovary Syndrome
Publication date: Available online 17 February 2020Source: MitochondrionAuthor(s): Pallavi Shukla, Srabani MukherjeeAbstractPolycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by irregular menstrual cycles, hyperandrogenism and subfertility. Due to its complex manifestation, the pathogenic mechanism of PCOS is not well defined. Cumulative effect of altered genetic and epigenetic factors along with environmental factors may play a role in the manifestation of PCOS leading to systemic malfunction. With failure of genome-wide association study (GWAS) and other studies performed on nuclear genome to p...
Source: Mitochondrion - February 18, 2020 Category: Biochemistry Source Type: research

Characterization of background noise in MiSeq MPS data when sequencing human mitochondrial DNA from various sample sources and library preparation methods
Publication date: Available online 14 February 2020Source: MitochondrionAuthor(s): Jennifer A. McElhoe, Mitchell M. HollandAbstractImproved resolution of massively parallel sequencing (MPS) allows for the characterization of mitochondrial (mt) DNA heteroplasmy to levels previously unattainable with traditional sequencing approaches. An essential criterion for the reporting of heteroplasmy is the ability of the MPS method to distinguish minor sequence variants (MSVs) from system noise, or error. Therefore, an assessment of the background noise in the MPS method is desirable to identify the point at which reliable data can b...
Source: Mitochondrion - February 15, 2020 Category: Biochemistry Source Type: research

Prophylaxis of Mitochondrial Dysfunction Caused by Cellular Decompression from Hyperbaric Exposure
Publication date: Available online 8 February 2020Source: MitochondrionAuthor(s): Abhay Ranganathan, Shawn Owiredu, David H. Jang, David M. EckmannAbstractMitochondrial dysfunction occurring in response to cellular perturbations can include altered mitochondrial motility and bioenergetic function having intracellular heterogeneity. Exogenous mitochondrial directed therapy may correct these dysfunctions. Using in vitro approaches, we find that cell perturbations induced by rapid decompression from hyperbaric conditions with specific gas exposures has differential effects on mitochondrial motility, inner membrane potential, ...
Source: Mitochondrion - February 10, 2020 Category: Biochemistry Source Type: research

qMGR: a new approach for quantifying mitochondrial genome rearrangement
We presented qMGR, a new approach for large-scale quantifying mitogenome rearrangements considering a single gene as a structural unit. Compared to a reference arrangement, qMGR accumulates the changes of two nearest neighbor genes to calculate rearrangement score (RS) and rearrangement frequency (RF) of each single gene in the mitogenomes of a given taxonomic group. By accumulating RS of all genes in one genome, qMGR was developed to calculate each mitogenome rearrangement score, which can be used as a quantitative feature of the mitogenome rearrangement. Based on the frequency of rearrangement of each gene, qMGR can furt...
Source: Mitochondrion - February 10, 2020 Category: Biochemistry Source Type: research

Coxfa4l3, a novel mitochondrial electron transport chain Complex 4 subunit protein, switches from Coxfa4 during spermatogenesis
Publication date: Available online 8 February 2020Source: MitochondrionAuthor(s): Masahiro Endou, Kaito Yoshida, Makoto Hirota, Chika Nakajima, Atsumi Sakaguchi, Naoto Komatsubara, Yasuyuki KuriharaAbstractWe identified Coxfa4l3, previously called C15orf48 or Nmes1, as a novel accessory protein of Complex IV of the mitochondrial electron transport chain (ETC). Amino acid sequence comparison, the intracellular localization and the protein expression data showed that the protein is the third isoform of Coxfa4 and the expression of Coxfa4 and Coxfa4l3 proteins during spermatogenesis showed a mutually exclusive pattern, implyi...
Source: Mitochondrion - February 10, 2020 Category: Biochemistry Source Type: research

Mitochondrial-associated impairments of Temozolomide on Neural Stem/Progenitor Cells and Hippocampal Neurons
In this study, we examined the mitochondrial-mediated mechanisms involving TMZ-induced neural damage in primary rat neural stem/progenitor cells (NSC) and hippocampal neurons. TMZ inhibited mtDNA replication and transcription of mitochondrial genes (ND1 and Cyt b) in NSC by 24 h, whereas the effect of TMZ on neuronal mtDNA transcription was less pronounced. Transmission electron microscopy imaging revealed mitochondrial degradation in TMZ-treated NSC. Acute TMZ exposure (4 h) caused a rapid reduction in dendritic branching and loss of postsynaptic density-95 (PSD95) puncta on dendrites. Longer TMZ exposure impaired mitocho...
Source: Mitochondrion - February 10, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: March 2020Source: Mitochondrion, Volume 51Author(s): (Source: Mitochondrion)
Source: Mitochondrion - February 8, 2020 Category: Biochemistry Source Type: research

Calcium Overload Decreases Net Free Radical Emission in Cardiac Mitochondria
In this study, we quantitatively demonstrate that, on the contrary, calcium does not stimulate free radical production but suppresses it. Isolated mitochondria from guinea pig hearts were energized with a variety of substrates and exposed to calcium concentrations designed to induce moderate calcium overload conditions associated with ischemia/reperfusion injury but do not elicit the well-known mitochondrial permeability transition phenomenon. Metabolic function and free radical emission were simultaneously quantified using high-resolution respirometry and fluorimetry. In parallel, membrane potential, high amplitude swelli...
Source: Mitochondrion - January 24, 2020 Category: Biochemistry Source Type: research

Detection of mitochondrial DNA variants at low level heteroplasmy in pediatric CNS and extra-CNS solid tumors with three different enrichment methods
This study demonstrates that LRPCR and SureSelect enrichment, but not REPLI-g, followed by NGS are accurate methods for studying the mtDNA variations at low heteroplasmy, which may be applied to studying mtDNA mutations in cancer. (Source: Mitochondrion)
Source: Mitochondrion - January 21, 2020 Category: Biochemistry Source Type: research

MMPdb and MitoPredictor: tools for facilitating comparative analysis of animal mitochondrial proteomes
In this study, we developed two resources to address these challenges: 1] the Metazoan Mitochondrial Proteome Database (MMPdb), which consolidates data on experimentally-characterized mitochondrial proteomes of vertebrate and invertebrate model organisms, and 2] MitoPredictor, a novel machine-learning tool for prediction of mitochondrial proteins in animals. MMPdb allows comparative analysis of animal mitochondrial proteomes by integrating results from orthology analysis, prediction of mitochondrial targeting signals, protein domain analysis, and Gene Ontology analysis. Additionally, for mammalian mitochondrial proteins, M...
Source: Mitochondrion - January 21, 2020 Category: Biochemistry Source Type: research

Redox Homeostasis, Oxidative Stress and Mitophagy
Publication date: Available online 20 January 2020Source: MitochondrionAuthor(s): Carla Garza-Lombó, Aglaia Pappa, Mihalis I. Panayiotidis, Rodrigo FrancoAbstractAutophagy is a ubiquitous homeostatic mechanism for the degradation or turnover of cellular components. Degradation of mitochondria via autophagy (mitophagy) is involved in a number of physiological processes including cellular homeostasis, differentiation and aging. Upon stress or injury, mitophagy prevents the accumulation of damaged mitochondria and the increased steady state levels of reactive oxygen species leading to oxidative stress and cell death. A...
Source: Mitochondrion - January 21, 2020 Category: Biochemistry Source Type: research

Cell stress management by the mitochondrial LonP1 protease – Insights into mitigating developmental, oncogenic and cardiac stress
Publication date: March 2020Source: Mitochondrion, Volume 51Author(s): Sundararajan Venkatesh, Carolyn K. SuzukiAbstractMitochondrial LonP1 is an essential stress response protease that mediates mitochondrial proteostasis, metabolism and bioenergetics. Homozygous and compound heterozygous variants in the LONP1 gene encoding the LonP1 protease have recently been shown to cause a diverse spectrum of human pathologies, ranging from classical mitochondrial disease phenotypes, profound neurologic impairment and multi-organ dysfunctions, some of which are uncommon to mitochondrial disorders. In this review, we focus primarily on...
Source: Mitochondrion - January 14, 2020 Category: Biochemistry Source Type: research

Relative Telomere Length and Mitochondrial DNA Copy Number Variation with Age: Association with Plasma Folate and Vitamin B12
This study aims to analyze the relative telomere length (rTL) and mitochondrial DNA copy number (mtCN) in aged individuals and their association with plasma folate and vitamin B12 levels. This community-based cross-sectional study involves 428 subjects (
Source: Mitochondrion - January 12, 2020 Category: Biochemistry Source Type: research