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Total 1283 results found since Jan 2013.

Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF- κB activation.
Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-κB activation. Biochem Biophys Res Commun. 2019 Apr 09;: Authors: Li Q, Dai Z, Cao Y, Wang L Abstract Stroke is a life-threatening neurological disease with limited therapeutic options. Inflammation is believed to be involved in the pathogenesis of ischemic stroke and contribute to the degree of brain injury. Vx-765 is a potent, selective, small-molecule caspase-1 inhibitor. Current studies have shown the anti-inflammatory properties of vx-765 in various disease; however, the ...
Source: Biochemical and Biophysical Research communications - April 8, 2019 Category: Biochemistry Authors: Li Q, Dai Z, Cao Y, Wang L Tags: Biochem Biophys Res Commun Source Type: research

Modulation and visualization of EF-G power stroke during ribosomal translocation.
Abstract During ribosome translocation, the elongation factor EF-G undergoes large conformational change while maintaining its contact with the moving tRNA. We previously measured a power stroke accompanying EF-G catalysis, which was consistent with structural studies. However, the role of power stroke in translocation fidelity remains unclear. Here, we report quantitative measurements of the power strokes of structurally modified EF-Gs using two different techniques, and reveal the correlation between power stroke and translocation efficiency and fidelity. We discovered that the reduced power stroke only lowered ...
Source: Chembiochem - June 12, 2019 Category: Biochemistry Authors: Xu S, Yin H, Gavriliuc M, Lin R, Wang Y Tags: Chembiochem Source Type: research

The protective effect of polyethylene glycol-conjugated urokinase nanogels in rat models of ischemic stroke when administrated outside the usual time window.
In conclusion, through the inhibition of LRP/NF-κB/Cox-2 pathway, the Caspase cascade and activation of NMDARs, administration of PEG-UK outside the usual time window could still exert protective effects in pMCAO rats through the maintenance of the integrity of BBB and the inhibition of apoptosis and excito-neurotoxicity. PMID: 31955887 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - January 15, 2020 Category: Biochemistry Authors: Cui W, Liu R, Jin H, Huang Y, Liu W, He M Tags: Biochem Biophys Res Commun Source Type: research

Serum uric acid and risk of stroke: a dose-response meta-analysis
In conclusion, high serum uric acid level increases the risk of stroke, with a non-linear dose-response relationship.PMID:34025024 | PMC:PMC8129984 | DOI:10.3164/jcbn.20-94
Source: Clinical Biochemistry - May 24, 2021 Category: Biochemistry Authors: Yunan Dong Han Shi Xinxin Chen Kailei Fu Jinwei Li Hanze Chen Weiyu Teng Li Tian Source Type: research

Effects of vitamin B < sub > 12 < /sub > deficiency on risk and outcome of ischemic stroke
Clin Biochem. 2023 May 27:110591. doi: 10.1016/j.clinbiochem.2023.110591. Online ahead of print.ABSTRACTIschemic stroke is the most prevalent form of stroke and has a high incidence in older adults, characterized by high morbidity, mortality, disability, and recurrence rate. Vitamin B12 deficiency is prevalent in the elderly and has been reported to be associated with ischemic stroke. The mechanisms maybe include the disorder of methylation metabolism, accumulation of toxic metabolites, immune dysfunction, affecting gut microbial composition and gut-brain immune homeostasis, and toxic stress responses to the brain. Vitamin...
Source: Clinical Biochemistry - May 29, 2023 Category: Biochemistry Authors: Li Zhou Xiaosong Song Jiani Wang Yongjun Tan Qin Yang Source Type: research

Inosine attenuates post-stroke neuroinflammation by modulating inflammasome mediated microglial activation and polarization
Biochim Biophys Acta Mol Basis Dis. 2023 Jun 5:166771. doi: 10.1016/j.bbadis.2023.166771. Online ahead of print.ABSTRACTTo date, various agents and molecules have been developed to treat post-stroke neuroinflammation; however, none of them are clinically successful. Post-stroke neuroinflammation is primarily attributed to microglial polarization as the generation of inflammasome complexes shifts microglia to their M1 phenotype and regulate the downstream cascade. Inosine, an adenosine derivative reported to maintain cellular energy homeostasis in stressed condition. Although, the exact mechanism is still unexplored, variou...
Source: Biochimica et Biophysica Acta - June 7, 2023 Category: Biochemistry Authors: Aishika Datta Pramod Suthar Deepaneeta Sarmah Poonam Jadhav Jinagna Shah Mounika Katamneni Nikhil Bhosale Vishal Gupta Mariya Bohra Falguni Baidya Nikita Rana Bijoyani Ghosh Harpreet Kaur Anupom Borah Rajeshwari Rathod Pinaki Sengupta Pallab Bhattacharya Source Type: research

Apolipoprotein E polymorphism and cerebral stroke.
Conclusions: The distribution of allelic frequencies of apolipoprotein E in the population of Constantine is similar to that of Southern Europe. Our results imply a role of the genotype of apolipoprotein E (ɛ4 allele) in the pathogenesis of stroke and are limited to the accidents of the ischemic type. The ɛ2 allele does not appear to be implied in occurred of this affection; however, large additional studies are necessary to confirm this result. PMID: 23396426 [PubMed - as supplied by publisher]
Source: Annales de Biologie Clinique - February 1, 2013 Category: Biochemistry Authors: Boumendjel S, Khodja D, Hamri A, Benlatreche C, Abadi N Tags: Ann Biol Clin (Paris) Source Type: research

Down regulation of brain cellular prion protein in an animal model of insulin resistance: Possible implication in increased prevalence of stroke in pre-diabetics/diabetics.
Abstract The risk of stroke is drastically increased in diabetic and pre-diabetic patients. The worldwide spread of obesity and insulin resistance increases the incidence of stroke. The direct effect of insulin resistance, as it pertains to stroke, on the central nervous system is not well understood. Since one of the physiological functions of the cellular prion protein (PrP(C)) is neuroprotection, we studied effects of brain insulin resistance on the expression of PrP(C) in fructose-fed rats as an animal model of prediabetes. Compared with control chow-fed animals, rats fed a high-fructose diet (FF), exhibited c...
Source: Biochemical and Biophysical Research communications - April 26, 2014 Category: Biochemistry Authors: Pham N, Khalaj S, Dhar A, Desai K, Taghibiglou C Tags: Biochem Biophys Res Commun Source Type: research

Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke.
Abstract Low frequency-pulsed electromagnetic fields (LF-PEMFs) affect many biological processes; however, the fundamental mechanisms responsible for these effects remain unclear. Our study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke. C57B6 mice were exposed to LF-PEMF (F = 60 Hz, Bm = 10 mT) after photothrombotic occlusion. We measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, and the expression of inflammatory mediators and performed behavioral tests in both LF-PEMF-treated and untreated ischemic stroke mice. O...
Source: Applied Biochemistry and Biotechnology - October 18, 2016 Category: Biochemistry Authors: Urnukhsaikhan E, Mishig-Ochir T, Kim SC, Park JK, Seo YK Tags: Appl Biochem Biotechnol Source Type: research

Serum trace elements are interrelated with hormonal imbalance in men with acute ischemic stroke
Conclusion Generally, the obtained data demonstrate that altered serum trace elements are associated with thyroid dysfunction in acute ischemic stroke patients. However, the causal relationship should be estimated.
Source: Journal of Trace Elements in Medicine and Biology - January 6, 2017 Category: Biochemistry Source Type: research

Blood based protein biomarkers for stroke differentiation: A systematic review
Conclusion: Our systematic review does not recommend the use of any blood biomarker for clinical purposes yet based on the studies conducted till date.This article is protected by copyright. All rights reserved
Source: Proteomics. Clinical Applications - April 28, 2017 Category: Biochemistry Authors: Shubham Misra, Amit Kumar, Pradeep Kumar, Arun K Yadav, Dheeraj Mohania, Awadh K Pandit, Kameshwar Prasad, Deepti Vibha Tags: Review Source Type: research