The protective effect of polyethylene glycol-conjugated urokinase nanogels in rat models of ischemic stroke when administrated outside the usual time window.

In conclusion, through the inhibition of LRP/NF-κB/Cox-2 pathway, the Caspase cascade and activation of NMDARs, administration of PEG-UK outside the usual time window could still exert protective effects in pMCAO rats through the maintenance of the integrity of BBB and the inhibition of apoptosis and excito-neurotoxicity.
PMID: 31955887 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - January 15, 2020 Category: Biochemistry Authors: Cui W, Liu R, Jin H, Huang Y, Liu W, He M Tags: Biochem Biophys Res Commun Source Type: research