Filtered By:
Specialty: Biochemistry

This page shows you your search results in order of relevance. This is page number 8.

Order by Relevance | Date

Total 1283 results found since Jan 2013.

Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived neuroinflammation and whether SIRT1 signaling was involved in this process. ARC (20 mg/kg) or vehicle were intraperitoneally injected to Sprague-Dawley rats for 3 days before middle cerebral artery occlusion (MCAO) surgery performed. The infarct volume, neurological score, brain water content, neuroinflammation, NLRP3 inflammasome activation and SIRT1 protein expression were assessed. Furthermore, we also investigated whether ARC protected against cerebral ischemia via SIRT1-dependent inhibition of NLRP3 inflamm...
Source: Biochemical and Biophysical Research communications - October 18, 2017 Category: Biochemistry Authors: Zhang S, Jiang L, Che F, Lu Y, Xie Z, Wang H Tags: Biochem Biophys Res Commun Source Type: research

RNA interference ‐mediated silencing of S100B improves nerve function recovery and inhibits hippocampal cell apoptosis in rat models of ischemic stroke
Conclusion: This study provides data to suggest that RNAi‐mediated silencing of S100B gene could improve the recovery of nerve function while inhibiting apoptosis of hippocampal cells in rats with ischemic stroke. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - January 31, 2018 Category: Biochemistry Authors: Jin ‐Hua Zhang, Jiang‐Kun Li, Li‐Li Ma, Ji‐Yu Lou Tags: Article Source Type: research

Overexpression of Egr2 and Egr4 protects rat brains against ischemic stroke by downregulating JNK signaling pathway.
CONCLUSION: Upregulation of Egr2 and Egr4 could demote the activation of JNK/c-JUN pathway and the expression of pro-inflammatory cytokines in MCAO rats, so that Egr2 and Egr4 might be potential targets for ischemic stroke in future. PMID: 29580816 [PubMed - as supplied by publisher]
Source: Biochimie - March 23, 2018 Category: Biochemistry Authors: Niu RN, Shang XP, Teng JF Tags: Biochimie Source Type: research

Cerebroprotection by progesterone following ischemic stroke: multiple effects and role of the neural progesterone receptors
Publication date: Available online 19 July 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Xiaoyan Zhu, Magalie Fréchou, Michael Schumacher, Rachida GuennounABSTRACTTreatment with progesterone limits brain damage after stroke. However, the cellular bases of the cerebroprotective effects of progesterone are not well documented. The aims of this study were to determine neural cells and functions that are affected by progesterone treatment and the role of neural progesterone receptors (PR) after stroke. Adult male PRNesCre mice, selectively lacking PR in the central nervous system, and their c...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 20, 2018 Category: Biochemistry Source Type: research

Inhibition of miR-19a protects neurons against ischemic stroke through modulating glucose metabolism and neuronal apoptosis.
Conclusions: Collectively, our results indicate that elevated miR-19a-3p mediates cerebral ischemic injury by targeting ADIPOR2. MiR-19a-3p attenuation thus might offer hope of a novel therapeutic target for ischemic stroke injury treatment. PMID: 31168302 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - June 8, 2019 Category: Biochemistry Authors: Ge XL, Wang JL, Liu X, Zhang J, Liu C, Guo L Tags: Cell Mol Biol Lett Source Type: research

Cyclic angiotensin-(1-7) contributes to rehabilitation of animal performance in a rat model of cerebral stroke
Publication date: Available online 5 November 2019Source: PeptidesAuthor(s): Anneke Kuipers, Gert N. Moll, Aharon Levy, Michael Krakovsky, Rick FranklinAbstractPeptidase-resistant, lanthionine-stabilized angiotensin-(1-7), termed cAng-(1-7), has shown therapeutic efficacy in animal models of cardiovascular, metabolic, kidney and pulmonary disease. Goal of the present study was testing the capacity of subcutaneously administered cAng-(1-7) to induce rehabilitation of animal performance in the transient middle cerebral artery occlusion rat model of cerebral stroke. 24 hours after ischemic stroke induction, cAng-(1-7) was a...
Source: Peptides - November 6, 2019 Category: Biochemistry Source Type: research

Micro RNA 146a gene variant / TNF- α/ IL-6/ IL-1 β; A cross-link axis inbetween oxidative stress, endothelial dysfunction and neuro-inflammation in acute ischemic stroke and chronic schizophrenic patients.
Micro RNA 146a gene variant / TNF-α/ IL-6/ IL-1 β; A cross-link axis inbetween oxidative stress, endothelial dysfunction and neuro-inflammation in acute ischemic stroke and chronic schizophrenic patients. Arch Biochem Biophys. 2019 Nov 15;:108193 Authors: Ibrahim RR, Amer RA, Abozeid AA, Elsharaby RM, Shafik NM Abstract This work was purposed to speculate the possible association of rs2910164hsa-miR-146a C>G gene single nucleotide polymorphism in the pathogenesis of schizophrenia and subsequently their relevance to neuro-inflammatory, vascular and oxidative stress pathways as acute ischemic strok...
Source: Archives of Biochemistry and Biophysics - November 14, 2019 Category: Biochemistry Authors: Ibrahim RR, Amer RA, Abozeid AA, Elsharaby RM, Shafik NM Tags: Arch Biochem Biophys Source Type: research

Microrheological disorders in patients with polycythemia vera suffered acute ischemic stroke
Mol Cell Biochem. 2022 Jan 4. doi: 10.1007/s11010-021-04352-6. Online ahead of print.ABSTRACTThe relevance of the study is determined by the fact that the combination of cerebrovascular disorders and myeloproliferative diseases requires the search for a predictive biomarker to improve outcomes. The aim of this article was to explore the meanings of microrheological disorders in patients with polycythemia vera (PV) who suffered an acute ischemic stroke (AIS). The study was carried out at the Research center of Neurology. We studied microrheological properties in 181 patients (aged 42-75 years). From the AIS developed in 68 ...
Source: Molecular and Cellular Biochemistry - January 5, 2022 Category: Biochemistry Authors: Marine Tanashyan Alla Shabalina Eugene Roitman Source Type: research

Effects of Oxidative Stress on Vascular Reactivity in the Offspring of Protein-Restricted Stroke-Prone Spontaneously Hypertensive Rats.
Abstract Oxidative stress was induced in 12-week-old offspring of protein-restricted (9% protein) and control (20% protein) protein-restricted stroke-prone spontaneously hypertensive rats (SHRSP) by administering phorbol 12-myristate 13-acetate (PMA) for 4 weeks to determine the effects of oxidative stress on the vascular function of the SHRSP offspring. There was no significant difference in the blood pressure of offspring of the protein-restricted dams and control dams. The plasma diacron-reactive oxygen metabolite (dROM) level at 16 weeks of age was significantly higher in offspring of the protein-restricted da...
Source: Bioscience, Biotechnology, and Biochemistry - August 7, 2013 Category: Biochemistry Authors: Takemori K, Tahara A, Murakami T, Kometani T Tags: Biosci Biotechnol Biochem Source Type: research

Validating Laboratory Results in a National Observational Cohort Study without Field Centers: the Reasons for Geographic and Racial Disparities in Stroke Cohort.
CONCLUSIONS: Simulation of non-optimal field processing and shipment to a central laboratory showed high variability in analytes released by platelets. The majority of other analytes produced valid results, but platelet contamination in REGARDS samples makes measurement of platelet proteins unadvisable in these samples. Future analytes considered by REGARDS or similar studies should undergo similar pilot testing. PMID: 25130959 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - August 14, 2014 Category: Biochemistry Authors: Gillett SR, Boyle RH, Zakai NA, McClure LA, Jenny NS, Cushman M Tags: Clin Biochem Source Type: research

Proteomic signatures of serum albumin-bound proteins from stroke patients with and without endovascular closure of PFO are significantly different and suggest a novel mechanism for cholesterol efflux
Conclusions The collective data presented in this study demonstrate that analysis of albumin-bound proteins could provide a valuable tool for biomarker discovery on the effects of PFO endovascular closure. In addition, the results suggest that PFO endovascular closure can potentially have effects on HDL, cholesterol and albumin-bound ApoA-I abundance, therefore possibly providing benefits in cardioprotective functions.
Source: Clinical Proteomics - January 13, 2015 Category: Biochemistry Source Type: research

Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats.
In conclusion, our data suggest that increased expression of hepatic antioxidative genes and modulation of Nrf2 may play a role in the regulation of metabolic diseases in SHRSP consuming a FBEP diet. PMID: 26072687 [PubMed - as supplied by publisher]
Source: Bioscience, Biotechnology, and Biochemistry - June 15, 2015 Category: Biochemistry Authors: Ardiansyah, Shirakawa H, Giriwono PE, Oguchi K, Ueda K, Hokazono H, Hiwatashi K, Takahashi S, Sato S, Komai M Tags: Biosci Biotechnol Biochem Source Type: research

A nonsense mutation of Stim1 identified in stroke-prone spontaneously hypertensive rats decreased the store-operated calcium entry in astrocytes.
In this study, we evaluated activity of the store-operated Ca(2+)-entry (SOCE) regulated by STIM1 to clarify putative functional abnormalities of the truncated STIM1. As a result, reduced SOCE activity resulting in suppression of cyclooxygenase-2 expression induced by SOCE was found in cultured astrocytes with the truncated STIM1 when compared with those with the wild-type. Our results indicated that the truncated STIM1 impaired Ca(2+) signaling regulated by SOCE and that the impaired SOCE activity might be responsible for pathological phenotypes in SHRSP. PMID: 27237974 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - May 25, 2016 Category: Biochemistry Authors: Ohara H, Nabika T Tags: Biochem Biophys Res Commun Source Type: research

Detection of multiple annexin autoantibodies in a patient with recurrent miscarriages, fulminant stroke and seronegative antiphospholipid syndrome.
Authors: Scholz P, Auler M, Brachvogel B, Benzing T, Mallman P, Streichert T, Klatt AR Abstract Anti-phospholipid syndrome (APS) is one of the main causes for recurrent miscarriages. The diagnosis of APS is based on the occurrence of clinical symptoms such as thrombotic events or obstetric complications as well as the detection of antiphospholipid antibodies directed against β2-glycoprotein I and cardiolipin, or a positive lupus anticoagulant assay. However, there is a subpopulation of patients with clinical symptoms of APS, but the lack of serological markers (seronegative APS). In addition, a large proportion of...
Source: Biochemia Medica - June 29, 2016 Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research

Role of Medicinal Plants for Liver ‐Qi Regulation Adjuvant Therapy in Post‐stroke Depression: A Systematic Review of Literature
Current evidence demonstrated certain beneficial effects of medicinal herbs as an adjuvant therapy for post‐stroke depression (PSD) in China; Chai‐hu (Chinese Thorowax Root, Radix Bupleuri) is an example of a medicinal plant for Liver‐Qi regulation (MPLR) in the treatment of PSD. Despite several narrative reports on the antidepressant properties of MPLR, it appears that there are no systematic reviews to summarize its outcome effects. Therefore, the aim of this review was to assess the effectiveness and safety of MPLR adjuvant therapy in patients with PSD. Seven databases were extensively searched from January 2000 u...
Source: Phytotherapy Research - October 19, 2016 Category: Biochemistry Authors: Ling ‐Feng Zeng, Ye Cao, Lu Wang, Yun‐Kai Dai, Ling Hu, Qi Wang, Li‐Ting Zhu, Wen‐Hu Bao, Yuan‐Ping Zou, Yun‐Bo Chen, Wei‐Hua Xu, Wei‐Xiong Liang, Ning‐Sheng Wang Tags: Review Source Type: research