Filtered By:
Specialty: Biochemistry
This page shows you your search results in order of date. This is page number 13.
Order by Relevance | Date
Total 1283 results found since Jan 2013.
Pathological implications of cellular stress in cardiovascular diseases
Int J Biochem Cell Biol. 2023 Mar 15:106397. doi: 10.1016/j.biocel.2023.106397. Online ahead of print.ABSTRACTCellular stress has been a key factor in the development of cardiovascular diseases. Major types of cellular stress such as mitochondrial stress, endoplasmic reticulum stress, hypoxia, and replicative stress have been implicated in clinical complications of cardiac patients. The heart is the central regulator of the body by supplying oxygenated blood throughout the system. Impairment of cellular function could lead to heart failure, myocardial infarction, ischemia, and even stroke. Understanding the effect of these...
Source: The International Journal of Biochemistry and Cell Biology - March 17, 2023 Category: Biochemistry Authors: Thennavan Ulaganathan Selene Perales Saiprahalad Mani Boula A Baskhairoun Johnson Rajasingh Source Type: research
The role of the blood-brain barrier during neurological disease and infection
Biochem Soc Trans. 2023 Mar 17:BST20220830. doi: 10.1042/BST20220830. Online ahead of print.ABSTRACTA healthy brain is protected by the blood-brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeostasis of the brain microenvironment and restricting pathogen and toxin entry to the brain. Dysfunction of this highly complex and regulated structure can be life threatening. BBB dysfunction is implicated in many neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis,...
Source: Biochemical Society Transactions - March 17, 2023 Category: Biochemistry Authors: Adjanie Patabendige Damir Janigro Source Type: research
Detection and Imaging of Active Substances in Early Atherosclerotic Lesions using Fluorescent Probes
Chembiochem. 2023 Mar 10:e202300105. doi: 10.1002/cbic.202300105. Online ahead of print.ABSTRACTAtherosclerosis (AS) is a vascular disease caused by chronic inflammation and lipids, which is the main cause of myocardial infarction, stroke and other cardiovascular diseases. Atherosclerosis is often difficult to detect in early stages due to the absence of clinically significant vascular stenosis. This is not conducive to the early intervention and treatment of the disease. Over the past decade, researchers have developed various imaging methods for the detection and imaging of atherosclerosis. At the same time, more and mor...
Source: Chembiochem - March 10, 2023 Category: Biochemistry Authors: Jin Li Jiheng Xu Wei Zhang Ping Li Wen Zhang Hui Wang Bo Tang Source Type: research
Role of oncostatin-M in ECM remodeling and plaque vulnerability
Mol Cell Biochem. 2023 Mar 1. doi: 10.1007/s11010-023-04673-8. Online ahead of print.ABSTRACTAtherosclerosis is a multifactorial inflammatory disease characterized by the development of plaque formation leading to occlusion of the vessel and hypoxia of the tissue supplied by the vessel. Chronic inflammation and altered collagen expression render stable plaque to unstable and increase plaque vulnerability. Thinned and weakened fibrous cap results in plaque rupture and formation of thrombosis and emboli formation leading to acute ischemic events such as stroke and myocardial infarction. Inflammatory mediators including TREM-...
Source: Molecular and Cellular Biochemistry - March 1, 2023 Category: Biochemistry Authors: Parth Patel Vikrant Rai Devendra K Agrawal Source Type: research
Prospects for the Use of Intranasally Administered Insulin and Insulin-Like Growth Factor-1 in Cerebral Ischemia
AbstractCurrent approaches to the treatment of stroke have significant limitations, and neuroprotective therapy is ineffective. In view of this, searching for effective neuroprotectors and developing new neuroprotective strategies remain a pressing topic in research of cerebral ischemia. Insulin and insulin-like growth factor-1 (IGF-1) play a key role in the brain functioning by regulating the growth, differentiation, and survival of neurons, neuronal plasticity, food intake, peripheral metabolism, and endocrine functions. Insulin and IGF-1 produce multiple effects in the brain, including neuroprotective action in cerebral...
Source: Biochemistry (Moscow) - March 1, 2023 Category: Biochemistry Source Type: research
Exploring the role of lipoprotein(a) in cardiovascular diseases and diabetes in Chinese population
Int J Biol Macromol. 2023 Feb 7:123586. doi: 10.1016/j.ijbiomac.2023.123586. Online ahead of print.ABSTRACTA high level of lipoprotein (a) in the plasma has been associated with a variety of cardiovascular diseases and is considered to be an independent predictor of some other diseases. Based on recent studies, the concentration levels of Lp(a) in the Chinese population exhibit a distinctive variation from other populations. In the Chinese population, a high level of Lp(a) indicates a higher incidence of revascularization, platelet aggregation, and thrombogenicity following PCI. Increased risk of atherosclerotic cardiovasc...
Source: International Journal of Biological Macromolecules - February 9, 2023 Category: Biochemistry Authors: Zubair Hussain Hongcai Liu Junaid Iqbal Hou-De Zhou Source Type: research
A search for acrolein scavengers among food components
In this study, we tried to identify food components which decrease acrolein toxicity. We found that 2-furanmethanethiol, cysteine methyl and ethyl esters, alliin, lysine and taurine decreased acrolein toxicity. These compounds neutralized acrolein by direct interaction. However, the interaction between acrolein and taurine was not so strong. Approximately 30 mM taurine was necessary to interact with 10 μM acrolein, and 2 g/kg taurine was necessary to decrease the size of mouse brain infarction. Taurine also slightly increased polyamine contents, which are involved in decrease in the acrolein toxicity. Mitochondrial potent...
Source: Amino Acids - February 8, 2023 Category: Biochemistry Authors: Takeshi Uemura Masashi Uchida Mizuho Nakamura Momo Shimekake Akihiko Sakamoto Yusuke Terui Kyohei Higashi Itsuko Ishii Keiko Kashiwagi Kazuei Igarashi Source Type: research
Accurately quantified plasma free glycine concentration as a biomarker in patients with acute ischemic stroke
Amino Acids. 2023 Jan 25. doi: 10.1007/s00726-023-03236-x. Online ahead of print.ABSTRACTWe developed a hollow fiber centrifugal ultrafiltration (HFCF-UF) method to study the change of plasma levels of free glycine (Gly) in patients with acute ischemic stroke (AIS). Twenty-four patients with AIS confirmed by diffusion-weighted imaging (DWI) were enrolled. During the study period, the patients did not receive any supplemental amino acids therapy that could affect the obtained results. Our results showed that although AIS patients adopted different methods of treatment (thrombolytic and non-thrombolytic), the clinical NIHSS ...
Source: Amino Acids - January 25, 2023 Category: Biochemistry Authors: Huan Wang Xiaoyu Ni Weichong Dong Weiman Qin Lei Xu Ye Jiang Source Type: research
Association of Angiotensin II Type 1 Receptor (AT1R) Gene Polymorphism with Angiotensin II Serum Levels in Patients with Essential Hypertension
This study aimed to determine genotype and allele frequencies of A1166C polymorphism of AT1R gene in Indian patients with EH and correlated with serum levels of Angiotensin II. A total of 200 patients with EH and 200 age- and gender-matched control individuals were included in this study from the General Medicine Department Outpatient at Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India. Patients with systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg were considered as hypertensive. The findings of this study revealed significantly increased risk of C/A heteroz...
Source: Clinical Biochemistry - January 23, 2023 Category: Biochemistry Authors: M Prasad D Rajarajeswari K Ramlingam R Viswakumar B Suneel Jyothi Conjeevaram P Aruna Nusrath Fathima Sandeep Kumar Vishwakarma Aleem Ahmed Khan Source Type: research
