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Specialty: Biochemistry
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Total 1283 results found since Jan 2013.
Effect of folic acid supplementation on the change of plasma < em > S < /em > -adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial
In conclusion, supplementation of 2.4 mg/day folic acid can lead to increased SAH levels, especially in MTHFR C677T genotype CT and TT.PMID:36447492 | PMC:PMC9701592 | DOI:10.3164/jcbn.22-13
Source: Clinical Biochemistry - November 30, 2022 Category: Biochemistry Authors: Ru-Shan Zhang Lei Tang Yan Zhang Xiu-Li Shi Ji Shu Li Wang Xu Zhang Ya-Ping Xu Jian-Fei Zou Rui Wang Hao Chen Gen-Fu Tang Source Type: research
miR-155-5p accelerates cerebral ischemia-reperfusion inflammation injury and cell pyroptosis via DUSP14/ TXNIP/NLRP3 pathway
CONCLUSION: Knockdown of miR-155-5p attenuated I/R inflammation and cell pyroptosis of cerebral via modulating DUSP14/TXNIP/NLRP3 pathway. These findings may provide a promising strategy to attenuate cerebral I/R injury.PMID:36441582 | DOI:10.18388/abp.2020_6095
Source: Acta Biochim Pol - November 28, 2022 Category: Biochemistry Authors: Yu Shi Zhendong Li Ke Li Ke Xu Source Type: research
Synthesis of novel 3-n-butylphthalide derivatives containing isopentenylphenol moiety as potential anti-platelet agents for the treatment of ischemic stroke
Chem Biodivers. 2022 Nov 24. doi: 10.1002/cbdv.202201002. Online ahead of print.ABSTRACTIn order to find novel anti-platelet drugs for the treatment of ischemic stroke, a series of 3-n-butylphthalide derivatives containing isopentenylphenol moiety were designed, synthesized and characterized with spectroscopic analyses. The in vitro antiplatelet activity results indicated that compound 3 better inhibited the arachidonic acid (AA) induced platelet aggregation than aspirin (ASP) and 3-n-butylphthalide (NBP). Additionally, compared with precursor NBP, compound 3 possessed outstanding antithrombotic activity in the animal expe...
Source: Chemistry and Biodiversity - November 24, 2022 Category: Biochemistry Authors: Qinyang Yu Bilan Luo Zhongfu Luo Xu Zhong Yi Li Yi Zhang Gaofeng Zhu Bing Guo Lei Tang Yong Li Lingling Fan Source Type: research
The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis
Biochem Soc Trans. 2022 Nov 23:BST20220441. doi: 10.1042/BST20220441. Online ahead of print.ABSTRACTAtherosclerosis is a chronic inflammatory disease characterized by lipid accumulation and plaque formation in arterial vessel walls. Atherosclerotic plaques narrow the arterial lumen to increase the risk of heart attacks, ischemic stroke and peripheral vascular disease, which are major and worldwide health and economic burdens. Macrophage accumulation within plaques is characteristic of all stages of atherosclerosis and their presence is a potential marker of disease activity and plaque stability. Macrophages engulf lipids a...
Source: Biochemical Society Transactions - November 23, 2022 Category: Biochemistry Authors: Heather M Wilson Source Type: research
Evaluation of targeted oxidative stress induced by oxygen-ozone < em > in vitro < /em > after ischemic induction
Redox Rep. 2022 Dec;27(1):259-269. doi: 10.1080/13510002.2022.2143104.ABSTRACTEncephalic vascular accident, or stroke, is the most common pathology of the central nervous system in humans, the second leading cause of death and physical and cognitive disabilities, in developing countries. It presents as an ischemic (more common) or hemorrhagic form. Ozone therapy has been shown to be effective in neuromodulation, neuroprotection, and nerve regeneration. The present study aimed to evaluate the effect of targeted mild ozone after inducing cerebral ischemia in vitro. Neuroblastoma lineage cells (SH-SY5Y) and canine amniotic me...
Source: Redox Report : communications in free radical research - November 10, 2022 Category: Biochemistry Authors: Jessica Rodrigues Orlandin Sarah Ingrid Pinto Santos Luciana Cristina Machado Paulo Fantinato Neto Fabiana Fernandes Bressan Naira Caroline Godoy Pieri Kaiana Recchia Meline de Paula Coutinho Priscilla Avelino Ferreira Pinto Annalisa Santucci Valter Trava Source Type: research
X-box binding protein 1 as a key modulator in "healing endothelial cells", a novel EC phenotype promoting angiogenesis after MCAO
CONCLUSIONS: Our study identified a novel disease-related EC subtype that showed high stemness to differentiate into other EC subtypes. The predicted molecule Xbp1 was thus confirmed as a key modulator that can promote angiogenesis and recover normal vasculature conformation.PMID:36348288 | DOI:10.1186/s11658-022-00399-5
Source: Cellular and Molecular Biology Letters - November 8, 2022 Category: Biochemistry Authors: Zhuohui Chen Xiang Wang Haiyue Wu Yishu Fan Zhouyi Yan Chenxiao Lu Hongfei Ouyang Shiyu Zhang Mengqi Zhang Source Type: research
