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Specialty: Biochemistry
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Total 1283 results found since Jan 2013.
Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research
Functional reconstruction of the impaired cortex and motor function by hMGEOs transplantation in stroke
Biochem Biophys Res Commun. 2023 Jun 3;671:87-95. doi: 10.1016/j.bbrc.2023.06.010. Online ahead of print.ABSTRACTStroke is the leading cause of death and long-term disability worldwide. But treatments are not available to promote functional recovery, and efficient therapies need to be investigated. Stem cell-based therapies hold great promise as potential technologies to restore function in brain disorders. Loss of GABAergic interneurons after stroke may result in sensorimotor defects. Here, by transplanting human brain organoids resembling the MGE domain (human MGE organoids, hMGEOs) derived from human induced pluripotent...
Source: Biochemical and Biophysical Research communications - June 10, 2023 Category: Biochemistry Authors: Shi-Ying Cao Meng-Dan Tao Shu-Ning Lou Di Yang Yu-Hui Lin Hai-Yin Wu Lei Chang Chun-Xia Luo Yun Xu Yan Liu Dong-Ya Zhu Source Type: research
Inosine attenuates post-stroke neuroinflammation by modulating inflammasome mediated microglial activation and polarization
Biochim Biophys Acta Mol Basis Dis. 2023 Jun 5:166771. doi: 10.1016/j.bbadis.2023.166771. Online ahead of print.ABSTRACTTo date, various agents and molecules have been developed to treat post-stroke neuroinflammation; however, none of them are clinically successful. Post-stroke neuroinflammation is primarily attributed to microglial polarization as the generation of inflammasome complexes shifts microglia to their M1 phenotype and regulate the downstream cascade. Inosine, an adenosine derivative reported to maintain cellular energy homeostasis in stressed condition. Although, the exact mechanism is still unexplored, variou...
Source: Biochimica et Biophysica Acta - June 7, 2023 Category: Biochemistry Authors: Aishika Datta Pramod Suthar Deepaneeta Sarmah Poonam Jadhav Jinagna Shah Mounika Katamneni Nikhil Bhosale Vishal Gupta Mariya Bohra Falguni Baidya Nikita Rana Bijoyani Ghosh Harpreet Kaur Anupom Borah Rajeshwari Rathod Pinaki Sengupta Pallab Bhattacharya Source Type: research
Effects of vitamin B < sub > 12 < /sub > deficiency on risk and outcome of ischemic stroke
Clin Biochem. 2023 May 27:110591. doi: 10.1016/j.clinbiochem.2023.110591. Online ahead of print.ABSTRACTIschemic stroke is the most prevalent form of stroke and has a high incidence in older adults, characterized by high morbidity, mortality, disability, and recurrence rate. Vitamin B12 deficiency is prevalent in the elderly and has been reported to be associated with ischemic stroke. The mechanisms maybe include the disorder of methylation metabolism, accumulation of toxic metabolites, immune dysfunction, affecting gut microbial composition and gut-brain immune homeostasis, and toxic stress responses to the brain. Vitamin...
Source: Clinical Biochemistry - May 29, 2023 Category: Biochemistry Authors: Li Zhou Xiaosong Song Jiani Wang Yongjun Tan Qin Yang Source Type: research
Kinases in cerebral cavernous malformations: Pathogenesis and therapeutic targets
Biochim Biophys Acta Mol Cell Res. 2023 May 18:119488. doi: 10.1016/j.bbamcr.2023.119488. Online ahead of print.ABSTRACTCerebral cavernous malformations (CCMs) are low-flow, hemorrhagic vascular lesions of the central nervous system of genetic origin, which can cause stroke-like symptoms and seizures. From the identification of CCM1, CCM2 and CCM3 as genes related to disease progression, molecular and cellular mechanisms for CCM pathogenesis have been established and the search for potential drugs to target CCM has begun. Broadly speaking, kinases are the major group signaling in CCM pathogenesis. These include the MEKK3/M...
Source: Biochimica et Biophysica Acta - May 20, 2023 Category: Biochemistry Authors: Chunxiao Qi Richard Sean Bujaroski Jonathan Baell Xiangjian Zheng Source Type: research
Interaction of exercise training with taurine attenuates infarct size and cardiac dysfunction via Akt-Foxo3a-Caspase-8 signaling pathway
Amino Acids. 2023 May 18. doi: 10.1007/s00726-023-03275-4. Online ahead of print.ABSTRACTThis research aimed to investigate the synergistic protective effect of exercise training and taurine on Akt-Foxo3a-Caspase-8 signaling related to infarct size and cardiac dysfunction. Therefore, 25 male Wistar rats with MI were divided into five groups: sham (Sh), control-MI(C-MI), exercise training-MI(Exe-MI), taurine supplementation-MI(Supp-MI), and exercise training + taurine-MI(Exe + Supp-MI). The taurine groups were given a 200 mg/kg/day dose of taurine by drinking water. Exercise training was conducted for 8 weeks (5 days/week),...
Source: Amino Acids - May 19, 2023 Category: Biochemistry Authors: Abolfazl Razzaghi Siroos Choobineh Abbasali Gaeini Rahman Soori Source Type: research
