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Total 1283 results found since Jan 2013.
Indole-3-carbinol mitigates oxidative stress and inhibits inflammation in rat cerebral ischemia/reperfusion model
The objective of our research was to evaluate the protective properties of indole-3-carbinol (I3C) and its effect on redox status parameters, inflammation, and apoptosis intensity in cerebral ischemia/reperfusion injury (CIRI) in rats. I3C administration to CIRI rats decreased levels of oxidative stress markers and improved aerobic metabolism compared to the animals with CIRI. A decrease in myeloperoxidase activity, proinflammatory cytokines mRNA levels, and expression of redox-sensitive factor Nuclear Factor-κB was observed in rats with CIRI that received I3C. I3C-treated rats with pathology showed decreased caspase acti...
Source: Biochimie - April 29, 2023 Category: Biochemistry Authors: Aleksandra Sergeevna Chichai Tatyana Nikolaevna Popova Evgenii Dmitrievich Kryl'skii Sergei Aleksandrovich Oleinik Grigorii Andreevich Razuvaev Source Type: research
Clinical Ageing
Subcell Biochem. 2023;103:437-458. doi: 10.1007/978-3-031-26576-1_16.ABSTRACTAgeing is generally characterised by the declining ability to respond to stress, increasing homeostatic imbalance, and increased risk of ageing-associated diseases . Mechanistically, the lifelong accumulation of a wide range of molecular and cellular impairments leads to organismal senescence. The aging population poses a severe medical concern due to the burden it places on healthcare systems and the general public as well as the prevalence of diseases and impairments associated with old age. In this chapter, we discuss organ failure during agein...
Source: Sub-Cellular Biochemistry - April 29, 2023 Category: Biochemistry Authors: Roxana Surugiu Daiana Burdusel Mihai-Andrei Ruscu Andreea Cercel Dirk M Hermann Israel Fernandez Cadenas Aurel Popa-Wagner Source Type: research
Indole-3-carbinol mitigates oxidative stress and inhibits inflammation in rat cerebral ischemia/reperfusion model
The objective of our research was to evaluate the protective properties of indole-3-carbinol (I3C) and its effect on redox status parameters, inflammation, and apoptosis intensity in cerebral ischemia/reperfusion injury (CIRI) in rats. I3C administration to CIRI rats decreased levels of oxidative stress markers and improved aerobic metabolism compared to the animals with CIRI. A decrease in myeloperoxidase activity, proinflammatory cytokines mRNA levels, and expression of redox-sensitive factor Nuclear Factor-κB was observed in rats with CIRI that received I3C. I3C-treated rats with pathology showed decreased caspase acti...
Source: Biochimie - April 29, 2023 Category: Biochemistry Authors: Aleksandra Sergeevna Chichai Tatyana Nikolaevna Popova Evgenii Dmitrievich Kryl'skii Sergei Aleksandrovich Oleinik Grigorii Andreevich Razuvaev Source Type: research
Clinical Ageing
Subcell Biochem. 2023;103:437-458. doi: 10.1007/978-3-031-26576-1_16.ABSTRACTAgeing is generally characterised by the declining ability to respond to stress, increasing homeostatic imbalance, and increased risk of ageing-associated diseases . Mechanistically, the lifelong accumulation of a wide range of molecular and cellular impairments leads to organismal senescence. The aging population poses a severe medical concern due to the burden it places on healthcare systems and the general public as well as the prevalence of diseases and impairments associated with old age. In this chapter, we discuss organ failure during agein...
Source: Sub-Cellular Biochemistry - April 29, 2023 Category: Biochemistry Authors: Roxana Surugiu Daiana Burdusel Mihai-Andrei Ruscu Andreea Cercel Dirk M Hermann Israel Fernandez Cadenas Aurel Popa-Wagner Source Type: research
