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Specialty: Biochemistry
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Total 1283 results found since Jan 2013.
Combined Application of Human Amniotic Membrane Mesenchymal Stem Cells and a Modified PGS-co-PCL Film in an Experimental Model of Myocardial Ischemia-Reperfusion Injury
Appl Biochem Biotechnol. 2023 Apr 3. doi: 10.1007/s12010-023-04446-5. Online ahead of print.ABSTRACTAccording to the World Health Organization (WHO), about 3.9 million people die annually of ischemic heart disease (IHD). Several clinical trials have shown that stem cell therapy is a promising therapeutic approach to IHD. Human amniotic membrane mesenchymal stem cells (hAMSCs) positively affect the repair of myocardial ischemia-reperfusion (MI/R) injury by stimulating endogenous repair mechanisms. The differentiated hAMSCs with and without modified PGS-co-PCL film were applied in the myocardium. MI/R injury was induced by l...
Source: Applied Biochemistry and Biotechnology - April 3, 2023 Category: Biochemistry Authors: Nastaran Bahrami Mahsa Ale-Ebrahim Yasin Asadi Nooshin Barikrow Ali Salimi Fatemeh Roholah Source Type: research
Comparative Investigation of Expression of Glutamatergic and GABAergic Genes in the Rat Hippocampus after Focal Brain Ischemia and Central LPS Administration
AbstractAmong the responses in the early stages of stroke, activation of neurodegenerative and proinflammatory processes in the hippocampus is of key importance for the development of negative post-ischemic functional consequences. However, it remains unclear, what genes are involved in these processes. The aim of this work was a comparative study of the expression of genes encoding glutamate and GABA transporters and receptors, as well as inflammation markers in the hippocampus one day after two types of middle cerebral artery occlusion (according to Koizumi et al. method, MCAO-MK, and Longa et al. method, MCAO-ML), an...
Source: Biochemistry (Moscow) - April 1, 2023 Category: Biochemistry Source Type: research
Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
Mol Cell Biochem. 2023 Mar 23:1-12. doi: 10.1007/s11010-023-04714-2. Online ahead of print.ABSTRACTAtherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and hypoxia precipitating angina. Chronic inflammation in the stable plaque renders it unstable and rupture of unstable plaques results in the formation of emboli leading to hypoxia/ischemia to the organs by occluding the terminal branches and precipitate myocardial infarction and stroke. Such delibitating events could be controlled by the strategies that prevent plaque development o...
Source: Molecular and Cellular Biochemistry - March 23, 2023 Category: Biochemistry Authors: Prathosh Velpuri Vikrant Rai Devendra K Agrawal Source Type: research
Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations
CONCLUSIONS: Our study provides, for the first time, evidence for the role of oscillatory shear stress in mediating the EndMT process and dysregulated expression of cell adhesion molecules, especially multifunctional integrin α9/β1 in human cAVM nidus. Concomitantly, our findings indicate the potential use of small-molecular inhibitors such as RO4929097 in the less-invasive therapeutic management of cAVMs.PMID:36934253 | PMC:PMC10024393 | DOI:10.1186/s11658-023-00436-x
Source: Cellular and Molecular Biology Letters - March 19, 2023 Category: Biochemistry Authors: C L Karthika Vani Venugopal B J Sreelakshmi S Krithika Jaya Mary Thomas Mathew Abraham C C Kartha Arumugam Rajavelu S Sumi Source Type: research
Pathological implications of cellular stress in cardiovascular diseases
Int J Biochem Cell Biol. 2023 Mar 15:106397. doi: 10.1016/j.biocel.2023.106397. Online ahead of print.ABSTRACTCellular stress has been a key factor in the development of cardiovascular diseases. Major types of cellular stress such as mitochondrial stress, endoplasmic reticulum stress, hypoxia, and replicative stress have been implicated in clinical complications of cardiac patients. The heart is the central regulator of the body by supplying oxygenated blood throughout the system. Impairment of cellular function could lead to heart failure, myocardial infarction, ischemia, and even stroke. Understanding the effect of these...
Source: The International Journal of Biochemistry and Cell Biology - March 17, 2023 Category: Biochemistry Authors: Thennavan Ulaganathan Selene Perales Saiprahalad Mani Boula A Baskhairoun Johnson Rajasingh Source Type: research
TGF- β1 ameliorates BBB injury and improves long-term outcomes in mice after ICH
Biochem Biophys Res Commun. 2023 Mar 6;654:136-144. doi: 10.1016/j.bbrc.2023.03.007. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a devastating subtype of stroke characterized by high mortality and morbidity rates with no effective treatment. TGF-β/ALK-5 signaling is reported to participated in the regulation of blood-brain barrier (BBB) integrity in the inflammation pain model, the effects of transforming growth factor (TGF)-β1 and the potential mechanisms on BBB after ICH have not been fully elucidated. Herein, we have demonstrated that peripheral administration of TGF-β1 reduces brain edema and ame...
Source: Biochemical and Biophysical Research communications - March 17, 2023 Category: Biochemistry Authors: Huimei Wen Jiaying Tan Mi Tian Yao Wang Yanqin Gao Ye Gong Source Type: research
The role of the blood-brain barrier during neurological disease and infection
Biochem Soc Trans. 2023 Mar 17:BST20220830. doi: 10.1042/BST20220830. Online ahead of print.ABSTRACTA healthy brain is protected by the blood-brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeostasis of the brain microenvironment and restricting pathogen and toxin entry to the brain. Dysfunction of this highly complex and regulated structure can be life threatening. BBB dysfunction is implicated in many neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis,...
Source: Biochemical Society Transactions - March 17, 2023 Category: Biochemistry Authors: Adjanie Patabendige Damir Janigro Source Type: research
