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Total 550 results found since Jan 2013.

Longitudinal Change of Plasma Retinol-Binding Protein 4 and its Relation to Neurological-Function Recovery, Relapse, and Death in Acute Ischemic Stroke Patients
Tohoku J Exp Med. 2023 Apr 27. doi: 10.1620/tjem.2023.J036. Online ahead of print.NO ABSTRACTPMID:37100600 | DOI:10.1620/tjem.2023.J036
Source: The Tohoku Journal of Experimental Medicine - April 26, 2023 Category: Research Authors: Chao Liu Juxian Gu Yan Yao Source Type: research

Prevalence and risk factors of retinal vein occlusion in the United States: The National Health and Nutrition Examination Survey, 2005 to 2008
Proc (Bayl Univ Med Cent). 2023 Feb 14;36(3):335-340. doi: 10.1080/08998280.2023.2173938. eCollection 2023.ABSTRACTRetinal vein occlusion (RVO) is a rare, vision-threatening vascular disorder. Due to limited recovery associated with RVO, prevention is essential. There is a significant discrepancy in previously reported epidemiological studies in the United States on the prevalence and risk factors of RVO. The purpose of this retrospective, cross-sectional study was to determine the prevalence and risk factors of RVO in adults ≥40 years of age in the US using the National Health and Nutrition Examination Survey (NHANES) 2...
Source: Baylor University Medical Center Proceedings - April 24, 2023 Category: Universities & Medical Training Authors: Praneeth Kalva Rubeel Akram Hafsa Z Zuberi Karanjit S Kooner Source Type: research

Progressive Central Artery Occlusion, Ophthalmic Artery Occlusion, and Hemispheric Intracranial Thrombosis after COVID-19 mRNA Vaccine Application: Case Report
Thromboembolic events as a result of COVID-19 mRNA vaccination are a rare, though life-threatening complication. In this case report, we describe a 40-year-old female patient who developed central retinal artery and ophthalmic artery occlusion progressing to intracranial thrombosis 3 weeks after vaccination with the Pfizer-BioNTech COVID-19 vaccine. Initially, she presented with progressive acute and painless unilateral vision loss in her left eye. Dilated fundoscopy of left eye showed macular whitening with sparing of the area of cilioretinal artery distribution. Labs revealed a normal erythrocyte sedimentation rate, C-re...
Source: Case Reports in Ophthalmology - April 18, 2023 Category: Opthalmology Source Type: research

Risk and risk factor of ischemic stroke after acute retinal arterial ischemia
ConclusionPatients have a high risk of ischemic stroke, particularly those with a diagnosis of ICAS ( ≥ 70%) or occlusion after the onset of ARAI. Clinical management of ARAI should focus on vascular risk factors control and secondary prevention for stroke.
Source: International Ophthalmology - March 28, 2023 Category: Opthalmology Source Type: research

Ocular and systemic determinants of perifoveal and macular vessel parameters in healthy African Americans
Conclusions When interpreting OCTA images in a clinical setting, it is important to consider the effects ocular and systemic characteristics may have on the macular microcirculation.
Source: British Journal of Ophthalmology - March 22, 2023 Category: Opthalmology Authors: Richter, G. M., Lee, J. C., Khan, N., Vorperian, A., Hand, B., Burkemper, B., Zhou, X., Chu, Z., Wang, R., Varma, R., Kashani, A. H. Tags: Original articles - Clinical science Source Type: research

The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
AbstractThe molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role ofApold1 (Apolipoprotein L domain containing 1) in angiogenesis in vivo and in vitro. Single-cell analyses reveal that - across tissues - the expression ofApold1 is restricted to the vasculature and thatApold1 expression in endothelial cells (ECs) is highly sensitive to environmental factors. UsingApold1−/− mice, we find thatApold1 is dispensable for development and does not affect postnatal retinal angiogenesis nor alters the ...
Source: Angiogenesis - March 18, 2023 Category: Molecular Biology Source Type: research

Systematic review of the relationship between Hollenhorst plaques and cerebrovascular events
CONCLUSION: The presence of asymptomatic retinal emboli indicates a risk of a cerebrovascular event when compared to patients with no plaques seen on fundoscopy. The evidence suggests that these patients warrant referral for medical optimization of cardiovascular risk factors. Currently, there is no recommendation to support carotid endarterectomy in patients with Hollenhorst plaques, or retinal emboli, and further studies are needed to assess this.PMID:36914563 | DOI:10.1177/17085381231163339
Source: Vascular - March 13, 2023 Category: Surgery Authors: Baker Moustafa Ghoneim Daniel Westby Mohamed Elsharkawi Marwa Said Stewart R Walsh Source Type: research

Quantification of retinal ganglion cell loss in patients with homonymous visual field defect due to stroke
ConclusionsReduction of SD-OCT parameters occurs following both ischaemic and haemorrhagic occipital stroke, but it is larger when the injury extends to parietal territories and increases as time since stroke increases. The size of visual field defect is unrelated to SD-OCT measurements. Macular GCC thinning appeared to be more sensitive than pRNFL in detecting retrograde retinal ganglion cell degeneration and its retinotopic pattern in stroke.
Source: Neurological Sciences - March 11, 2023 Category: Neurology Source Type: research

Mitral Valve Blood Cyst and Multi-Territory Ischaemic Stroke
A 78-year-old male with a history of hypertension and hypercholesterolaemia was admitted to hospital with acute left eye visual loss and diagnosed with retinal artery occlusion. Magnetic resonance imaging (MRI) revealed multiple, bilateral cerebral infarcts involving supra- and infra-tentorial brain consistent with acute ischaemic stroke from a central embolic source. Extended ambulatory electrocardiographic monitoring displayed sinus rhythm with no evidence of atrial flutter or fibrillation. Transthoracic echocardiography (TTE) revealed a cystic structure associated with the mitral valve, with no restriction or regurgitation.
Source: Heart, Lung and Circulation - February 16, 2023 Category: Cardiology Authors: Caitlin Paul, Luke Cieslik, Alan Appelbe, Catherine Jaworski Tags: Image Source Type: research

Janssen Data at ASCO GU Support Ambition to Transform Treatment of Prostate and Bladder Cancer Through Precision Medicine and Early Intervention
RARITAN, N.J., February 13, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced plans to present more than 20 abstracts featuring seven oncology therapies from its robust portfolio and pipeline at the annual American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium, taking place in San Francisco on February 16-18. Building on more than a decade of leadership in the development of medicines for people diagnosed with GU cancers, Janssen will present data demonstrating its ambition to advance patient-centered treatment through precision medicine, real-world evidence a...
Source: Johnson and Johnson - February 13, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications —risks and mitigation
AbstractProliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age population. The current screening process for the DR risk is not sufficiently effective such that often the disease is undetected until irreversible damage occurs. Diabetes-associated small vessel disease and neuroretinal changes create a vicious cycle resulting in the conversion of DR into PDR with characteristic ocular attributes including excessive mitochondrial and retinal cell damage, chronic inflammation, neovascularisation, a...
Source: EPMA Journal - February 13, 2023 Category: International Medicine & Public Health Source Type: research