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Total 550 results found since Jan 2013.

Retinal Vasculature Reactivity During Flicker Light Provocation, Cardiac Stress and Stroke Risk in Africans: The SABPA Study
AbstractStructural and functional similarities exist between the retinal, cerebral and, as previously suggested, the coronary microvasculature. Retinal microvascular structure and functionality (in response to flicker-light-induced-provocation (FLIP)) may relate to coronary artery disease risk and possible stroke risk. We investigated associations between retinal vessel structure, functionality and cardiac stress markers (cardiac troponin T [cTnT], amino-terminal B-type natriuretic peptide [NT-proBNP]) to translate these retina –heart relationships to stroke risk. We included 317 African and Caucasian teachers’ (aged 2...
Source: Translational Stroke Research - November 9, 2018 Category: Neurology Source Type: research

Tissue-Based Stroke Definition Impacts Stroke Incidence but not Ethnic Differences
In 2013, a new stroke definition was promulgated.1 Ischemic stroke was defined as an episode of neurologic dysfunction resulting from “CNS infarction.” The term CNS infarction included not only patients with clinical symptoms lasting greater than 24 h, but also those who had MRI diffusion positive signal with symptoms less than 24 h in duration. It also included retinal and spinal cord infarction as well as cerebral venous s inus thrombosis with infarction. All of these factors would increase previous estimates of ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - March 21, 2021 Category: Neurology Authors: Lewis B. Morgenstern, Darin B. Zahuranec, Jaewon Lim, Xu Shi, Devin L. Brown, Kevin A. Kerber, William J. Meurer, Lesli E. Skolarus, Eric E. Adelman, Morgan S. Campbell, Erin Case, Lynda D. Lisabeth Source Type: research

Prevalence of Retinal Emboli and Acute Retinal Artery Occlusion in Acute Ischemic Stroke
In population-based studies asymptomatic retinal emboli occur in .32%-2.9% of people. Retinal artery occlusion (RAO) may occur concurrently with cerebral stroke but the frequency is unknown. No study has examined how commonly retinal emboli occur in the acute stroke population. We aimed to assess the prevalence of retinal emboli and RAO at the time of carotid territory ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2019 Category: Neurology Authors: Robert A. Egan, Helmi L. Lutsep Source Type: research

Comparison of Prediction Models based on Risk Factors and Retinal Characteristics Associated with Recurrence One Year after Ischemic Stroke
Patients who survive an ischemic stroke have a high risk of stroke recurrence within a year. About 80%-85% of patients who have survived a first ischemic stroke would suffer at least 1 recurrence, and 8%-15% of the recurrences occurred in the first year.1
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2020 Category: Neurology Authors: Zhuo Yuanyuan, Wu Jiaman, Qu Yimin, Yu Haibo, Yuan Weiqu, Yang Zhuoxin Source Type: research

Comments on Coronavirus Positive Patients Presenting with Stroke-Like Symptoms
We read with interest the short communication entitled “Coronavirus Positive Patients Presenting with Stroke-Like Symptoms”,1 it was a case series on stroke presentation over COVID-19 patients. We are particularly interested on patient 10, the one and only one central retinal artery occlusion (CRAO) case secondary to occlusive thrombus in the intern al carotid artery (ICA), who was also highlighted by the authors. CRAO is a blinding ocular emergency, and a harbinger of ischemic cerebrovascular stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2021 Category: Neurology Authors: Sunny Chi Lik Au, Callie Ka Li Ko Tags: Letter to Editor Source Type: research

Plasma Retinol-Binding Protein 4 Levels and the Risk of Ischemic Stroke among Women
Plasma retinol-binding protein 4 (RBP4) levels have been associated with cardiovascular risk factors and risk of coronary heart disease, but little is known about the association between RBP4 and the risk of ischemic stroke. We hypothesized that elevated RBP4 levels would be associated with an increased risk of ischemic stroke among women.
Source: Journal of Stroke and Cerebrovascular Diseases - September 6, 2017 Category: Neurology Authors: Pamela M. Rist, Monik C. Jim énez, Shelley S. Tworoger, Frank B. Hu, JoAnn E. Manson, Qi Sun, Kathryn M. Rexrode Source Type: research

Serum Retinoic Acid Level and The Risk of Poststroke Cognitive Impairment in Ischemic Stroke Patients
This study aimed to detect the association between RA level and PSCI among patients with first-ever acute ischemic stroke. Methods: Two hundred and 61 consecutive patients were prospectively recruited during March 2018 and March 2019.
Source: Journal of Stroke and Cerebrovascular Diseases - September 5, 2019 Category: Neurology Authors: Le Hou, Caixia Ding, Zhao Chen, Yuanyue Liu, Haishan Shi, Cong Zou, Hui Zhang, Zhiwei Lu, Dong Zheng Source Type: research

Similarities and Differences in Systemic Risk Factors for Retinal Artery Occlusion and Stroke: A Nationwide Case-Control Study
This study compares risk factor profiles for thromboembolism among patients with RAO and stroke, respectively.
Source: Journal of Stroke and Cerebrovascular Diseases - June 28, 2022 Category: Neurology Authors: Marie Ørskov, Henrik Vorum, Torben Bjerregaard Larsen, Gregory Y.H. Lip, Toke Bek, Flemming Skjøth Source Type: research

Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations Clinical Sciences
Background and Purpose—Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia. The pathophysiology of RVCL-S is largely unknown, but systemic endothelial involvement has been suggested, leading to pathology in the brain and other highly vascularized organs. Here, we investigated circulating endothelial markers to confirm endothelial involvement and identify biomarkers for disease activity.Methods—We measured circulating levels of von W...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Nadine Pelzer, Roel Bijkerk, Marlies E.J. Reinders, Anton Jan van Zonneveld, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Jeroen Eikenboom, Gisela M. Terwindt Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Genetics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study.
Conclusions: People with RVO are at a significantly greater risk of developing stroke, ischemic stroke, and hemorrhagic stroke. However, RVO does not significantly increase the risk of all-cause mortality. PMID: 30271630 [PubMed]
Source: Journal of Ophthalmology - October 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
ConclusionA fast and fully automatic method can be used for stroke subtype risk assessment and classification based on fundus photographs alone.
Source: Frontiers in Neurology - August 22, 2022 Category: Neurology Source Type: research

Plasma retinol and the risk of first stroke in hypertensive adults: a nested case-control study.
Conclusions: Our data showed a significant inverse association between plasma retinol and the risk of first stroke among Chinese hypertensive adults. This study was registered at clinicaltrials.gov as NCT00794885. PMID: 30624586 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 9, 2019 Category: Nutrition Authors: Yu Y, Zhang H, Song Y, Lin T, Zhou Z, Guo H, Liu L, Wang B, Liu C, Li J, Zhang Y, Huo Y, Wang C, Wang X, Hou FF, Qin X, Xu X Tags: Am J Clin Nutr Source Type: research

The impact of parental risk factors on the risk of stroke in type 1 diabetes
ConclusionA history of maternal stroke increases the risk of hemorrhagic stroke in individuals with type 1 diabetes. Other parental risk factors seem to have limited impact on the risk of stroke.
Source: Acta Diabetologica - March 15, 2021 Category: Endocrinology Source Type: research

Serum retinol-binding protein 4 in stroke patients: correlation with T helper 17/regulatory T cell imbalance and 3-year cognitive function decline
ConclusionSerum RBP4 is positively associated with a Th17/Treg cell imbalance and, more importantly, it is indicative of cognitive function decline within 3 years in stroke patients. Thus, early and timely interventions and physical rehabilitation are more necessary in stroke patients with high serum RBP4.
Source: Frontiers in Neurology - September 21, 2023 Category: Neurology Source Type: research

Who Should Rather Undergo Transesophageal Echocardiography to Determine Stroke Etiology: Young or Elderly Stroke Patients?
Conclusions: TEE was highly valuable for determining stroke etiology and influenced individual secondary prevention based on available treatment guidelines and expert opinion in most cases. In young patients the impact of TEE was limited to the detection of septal anomalies. By contrast, in older patients TEE detected high numbers of complex aortic atheroma and potential indicators of paroxysmal atrial fibrillation.
Source: Frontiers in Neurology - December 18, 2020 Category: Neurology Source Type: research