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Total 550 results found since Jan 2013.

Central retinal artery occlusion: a retrospective study of disease presentation, treatment, and outcomes
CONCLUSIONS: The majority of patients with CRAO presented to eye care providers, and few present within the potential window for thrombolysis of 4.5 hours, highlighting the need for public awareness strategies. Our cohort highlights the significant rate of systemic comorbidity that exists in these patients.PMID:35307340 | DOI:10.1016/j.jcjo.2022.02.015
Source: Canadian Journal of Ophthalmology - March 21, 2022 Category: Opthalmology Authors: Meghan J Smith Matthew D Benson Matthew Tennant Imran Jivraj Source Type: research

Clinical risk factors for retinal artery occlusions: a nationwide case-control study
CONCLUSION: The investigated risk factors suggest that atherosclerosis and conditions changing the intraocular pressure are involved in the pathophysiology of RAO.PMID:35305540 | DOI:10.1007/s10792-022-02247-z
Source: Atherosclerosis - March 19, 2022 Category: Cardiology Authors: Marie Ørskov Henrik Vorum Torben Bjerregaard Larsen Gregory Y H Lip Toke Bek Flemming Skj øth Source Type: research

Clinical risk factors for retinal artery occlusions: a nationwide case –control study
ConclusionThe investigated risk factors suggest that atherosclerosis and conditions changing the intraocular pressure are involved in the pathophysiology of RAO.
Source: International Ophthalmology - March 19, 2022 Category: Opthalmology Source Type: research

Association of retinal atherosclerosis assessed using Keith-Wagener-Barker system with incident heart failure and other atherosclerotic cardiovascular disease: Analysis of 319,501 individuals from the general population
CONCLUSIONS: The assessment of RA may be useful to identify people at high-risk for the development of HF and other atherosclerotic CVD events in a general population.PMID:35292151 | DOI:10.1016/j.atherosclerosis.2022.02.024
Source: Atherosclerosis - March 16, 2022 Category: Cardiology Authors: Satoshi Matsuoka Hidehiro Kaneko Akira Okada Hidetaka Itoh Yuta Suzuki Katsuhito Fujiu Nobuaki Michihata Taisuke Jo Norifumi Takeda Hiroyuki Morita Sunao Nakamura Koichi Node Hideo Yasunaga Issei Komuro Source Type: research

AlzEye: longitudinal record-level linkage of ophthalmic imaging and hospital admissions of 353 157 patients in London, UK
Purpose Retinal signatures of systemic disease (‘oculomics’) are increasingly being revealed through a combination of high-resolution ophthalmic imaging and sophisticated modelling strategies. Progress is currently limited not mainly by technical issues, but by the lack of large labelled datasets, a sine qua non for deep learning. Such data are derived from prospective epidemiological studies, in which retinal imaging is typically unimodal, cross-sectional, of modest number and relates to cohorts, which are not enriched with subpopulations of interest, such as those with systemic disease. We thus linked longitu...
Source: BMJ Open - March 16, 2022 Category: General Medicine Authors: Wagner, S. K., Hughes, F., Cortina-Borja, M., Pontikos, N., Struyven, R., Liu, X., Montgomery, H., Alexander, D. C., Topol, E., Petersen, S. E., Balaskas, K., Hindley, J., Petzold, A., Rahi, J. S., Denniston, A. K., Keane, P. A. Tags: Open access, Ophthalmology Source Type: research

Retinal microvascular abnormalities and risks of incident stroke and its subtypes: The Circulatory Risk in Communities Study
Conclusion: Retinal microvascular abnormalities were positively associated with the risk of incident stroke in the general Japanese population. Routine retinal photography could provide positive clinical insights into stroke risk stratification independent of blood pressure, antihypertensive medication use, and other risk factors.
Source: Journal of Hypertension - March 10, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy
Biosci Rep. 2022 Mar 31;42(3):BSR20212209. doi: 10.1042/BSR20212209.ABSTRACTDiabetes mellitus is a chronic metabolic disease that occurs when the pancreas is not producing enough insulin or when the insulin that it does produce is not able to be used effectively in the body. This results in hyperglycemia and if the blood sugars are not controlled, then it can lead to serious damage of various body systems, especially the nerves and the blood vessels. Uncontrolled diabetes is a major cause of kidney failure, heart attacks, stroke and amputation. One of the most devastating complications for patients is diabetic retinopathy ...
Source: Bioscience Reports - March 2, 2022 Category: Biomedical Science Authors: Jennifer Matthews Lakshini Herat Jennifer Rooney Elizabeth Rakoczy Markus Schlaich Vance B Matthews Source Type: research

The New Era of Retinal Imaging in Hypertensive Patients
Structural and functional alterations in the microcirculation by systemic hypertension can cause significant organ damage at the eye, heart, brain, and kidneys. As the retina is the only tissue in the body that allows direct imaging of small vessels, the relationship of hypertensive retinopathy signs with development of disease states in other organs have been extensively studied; large-scale epidemiological studies using fundus photography and advanced semi-automated analysis software have reported the association of retinopathy signs with hypertensive end-organ damage includes the following: stroke, dementia, and coronar...
Source: Asia-Pacific Journal of Ophthalmology - March 1, 2022 Category: Opthalmology Tags: Review Article Source Type: research

Current Guidelines on Management of Amaurosis Fugax and Transient Ischemic Attacks
Transient ischemic attack (TIA) is defined as a transient episode of neurological dysfunction resulting from focal brain, spinal cord, or retinal ischemia, without associated infarction. Consequently, a TIA encompasses amaurosis fugax (AF) that is a term used to denote momentary visual loss from transient retinal ischemia. In this review, we use the word TIA to refer to both cerebral TIAs (occurring in the brain) and AF (occurring in the retina). We summarize the key components of a comprehensive evaluation and management of patients presenting with cerebral and retinal TIA. All TIAs should be treated as medical emergen...
Source: Asia-Pacific Journal of Ophthalmology - March 1, 2022 Category: Opthalmology Tags: Review Article Source Type: research

Association between retinal vascular measures and brain white matter lesions in schizophrenia
We examined brain white matter lesions as they are considered a predictive marker for future adverse cerebrovascular event.METHODS: We acquired retinal vascular images of both eyes using a non-mydriatic camera and calculated retinal vascular diameter, tortuosity, trajectory and fractal dimension using validated methods. All patients underwent Magnetic Resonance Imaging of bran and we computed white matter hypo-intensities using Freesurfer software. We performed a linear regression analysis to examine the relationship between white matter hypo-intensities and retinal vascular measures controlling for age, sex, fasting blood...
Source: Asian Journal of Psychiatry - February 27, 2022 Category: Psychiatry Authors: Vittal Korann Satish Suhas Abhishek Appaji Bhargavi Nagendra Ananth Padmanabha Arpitha Jacob Priyanka Devi Rose Dawn Bharath Vijay Kumar Shivarama Varambally Ganesan Venkatasubramanian Shyam Vasudeva Rao Caroll Ab Webers Tos Tjm Berendschot Naren P Rao Source Type: research