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Total 550 results found since Jan 2013.

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study
To estimate National Institutes of Health Stroke Scale (NIHSS) grading of stroke patients with retinal characteristics. A cross-sectional study was conducted in Shenzhen Traditional Chinese Medicine Hospital. Baseline information and retinal photos were collected within 2 weeks of admission. An NIHSS score was measured for each patient by trained doctors. Patients were classified into 0 to 4 score group and 5 to 42 score group for analysis. Three multivariate logistic models, with traditional clinical characteristics alone, with retinal characteristics alone, and with both, were built. For clinical characteristics, h...
Source: Medicine - August 6, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Update on intravenous lysis treatment : The REVISION trial
CONCLUSION: The efficacy of intravenous thrombolysis in acute ischemic stroke is critically time dependent. This may also be assumed in acute CRAO; however, definite evidence still needs to be provided. Until then, the motto "time is retina" should be applied and intravenous thrombolysis should be offered to CRAO patients as part of randomized trials (such as REVISION). According to the current literature, other acute treatment approaches (such as paracentesis) are not indicated.PMID:34351478 | DOI:10.1007/s00347-021-01467-5
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Maximilian Schultheiss Martin S Spitzer Lars-Olof Hattenbach Sven Poli Source Type: research

Nonaretritic central retinal artery occlusion as marker for the generalized vascular risk
CONCLUSION: Although cardiovascular diseases are already known in most patients at the onset of an RAO, further risk factors are detected in almost 80% of cases. Therefore, and because of the high risk for recurrent thromboembolism, immediate and standardized neurological internal medical clarification of the cause is urgently recommended after an acute RAO in the context of an inpatient stay.PMID:34350493 | DOI:10.1007/s00347-021-01466-6
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Nicolas Feltgen Jan Liman Maximilian Schultheiss Martin S Spitzer Amelie Pielen Sven Poli Source Type: research

Update on intravenous lysis treatment : The REVISION trial
CONCLUSION: The efficacy of intravenous thrombolysis in acute ischemic stroke is critically time dependent. This may also be assumed in acute CRAO; however, definite evidence still needs to be provided. Until then, the motto "time is retina" should be applied and intravenous thrombolysis should be offered to CRAO patients as part of randomized trials (such as REVISION). According to the current literature, other acute treatment approaches (such as paracentesis) are not indicated.PMID:34351478 | DOI:10.1007/s00347-021-01467-5
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Maximilian Schultheiss Martin S Spitzer Lars-Olof Hattenbach Sven Poli Source Type: research

Nonaretritic central retinal artery occlusion as marker for the generalized vascular risk
CONCLUSION: Although cardiovascular diseases are already known in most patients at the onset of an RAO, further risk factors are detected in almost 80% of cases. Therefore, and because of the high risk for recurrent thromboembolism, immediate and standardized neurological internal medical clarification of the cause is urgently recommended after an acute RAO in the context of an inpatient stay.PMID:34350493 | DOI:10.1007/s00347-021-01466-6
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Nicolas Feltgen Jan Liman Maximilian Schultheiss Martin S Spitzer Amelie Pielen Sven Poli Source Type: research

Update on intravenous lysis treatment : The REVISION trial
CONCLUSION: The efficacy of intravenous thrombolysis in acute ischemic stroke is critically time dependent. This may also be assumed in acute CRAO; however, definite evidence still needs to be provided. Until then, the motto "time is retina" should be applied and intravenous thrombolysis should be offered to CRAO patients as part of randomized trials (such as REVISION). According to the current literature, other acute treatment approaches (such as paracentesis) are not indicated.PMID:34351478 | DOI:10.1007/s00347-021-01467-5
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Maximilian Schultheiss Martin S Spitzer Lars-Olof Hattenbach Sven Poli Source Type: research

Nonaretritic central retinal artery occlusion as marker for the generalized vascular risk
CONCLUSION: Although cardiovascular diseases are already known in most patients at the onset of an RAO, further risk factors are detected in almost 80% of cases. Therefore, and because of the high risk for recurrent thromboembolism, immediate and standardized neurological internal medical clarification of the cause is urgently recommended after an acute RAO in the context of an inpatient stay.PMID:34350493 | DOI:10.1007/s00347-021-01466-6
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Nicolas Feltgen Jan Liman Maximilian Schultheiss Martin S Spitzer Amelie Pielen Sven Poli Source Type: research

Update on intravenous lysis treatment : The REVISION trial
CONCLUSION: The efficacy of intravenous thrombolysis in acute ischemic stroke is critically time dependent. This may also be assumed in acute CRAO; however, definite evidence still needs to be provided. Until then, the motto "time is retina" should be applied and intravenous thrombolysis should be offered to CRAO patients as part of randomized trials (such as REVISION). According to the current literature, other acute treatment approaches (such as paracentesis) are not indicated.PMID:34351478 | DOI:10.1007/s00347-021-01467-5
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Maximilian Schultheiss Martin S Spitzer Lars-Olof Hattenbach Sven Poli Source Type: research

Nonaretritic central retinal artery occlusion as marker for the generalized vascular risk
CONCLUSION: Although cardiovascular diseases are already known in most patients at the onset of an RAO, further risk factors are detected in almost 80% of cases. Therefore, and because of the high risk for recurrent thromboembolism, immediate and standardized neurological internal medical clarification of the cause is urgently recommended after an acute RAO in the context of an inpatient stay.PMID:34350493 | DOI:10.1007/s00347-021-01466-6
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Nicolas Feltgen Jan Liman Maximilian Schultheiss Martin S Spitzer Amelie Pielen Sven Poli Source Type: research

Update on intravenous lysis treatment : The REVISION trial
CONCLUSION: The efficacy of intravenous thrombolysis in acute ischemic stroke is critically time dependent. This may also be assumed in acute CRAO; however, definite evidence still needs to be provided. Until then, the motto "time is retina" should be applied and intravenous thrombolysis should be offered to CRAO patients as part of randomized trials (such as REVISION). According to the current literature, other acute treatment approaches (such as paracentesis) are not indicated.PMID:34351478 | DOI:10.1007/s00347-021-01467-5
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Maximilian Schultheiss Martin S Spitzer Lars-Olof Hattenbach Sven Poli Source Type: research

Nonaretritic central retinal artery occlusion as marker for the generalized vascular risk
CONCLUSION: Although cardiovascular diseases are already known in most patients at the onset of an RAO, further risk factors are detected in almost 80% of cases. Therefore, and because of the high risk for recurrent thromboembolism, immediate and standardized neurological internal medical clarification of the cause is urgently recommended after an acute RAO in the context of an inpatient stay.PMID:34350493 | DOI:10.1007/s00347-021-01466-6
Source: Der Ophthalmologe - August 5, 2021 Category: Opthalmology Authors: Nicolas Feltgen Jan Liman Maximilian Schultheiss Martin S Spitzer Amelie Pielen Sven Poli Source Type: research

Risk Stratification Tool for Ischemic Stroke: A Risk Assessment Model Based on Traditional Risk Factors Combined With White Matter Lesions and Retinal Vascular Caliber
Conclusion: The risk assessment model of ischemic stroke combined with Fazekas grade of WML and CRAE is superior to the traditional risk factor and the single-index model. This model is helpful for risk stratification of high-risk stroke patients.
Source: Frontiers in Neurology - August 4, 2021 Category: Neurology Source Type: research

Immuno-histological detection of resistant columnar units and vulnerable networks in the rat retina after asphyxia-induced transient cardiac arrest
CONCLUSIONS: Regardless of the many defects, the surviving neuronal structures seemed to be able to maintain retinal functionality, which can be additionally improved by regenerative processes true to the "use it or lose it" dogma.PMID:34334436 | DOI:10.3233/RNN-211174
Source: Restorative Neurology and Neuroscience - August 2, 2021 Category: Neurology Authors: Gerburg Keilhoff Maximilian Titze Uwe Ebmeyer Source Type: research