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Total 550 results found since Jan 2013.
Retinal artery/vein occlusion complicating SARS-CoV-2 vaccinations
Letter to the Editor
Source: Journal of Stroke and Cerebrovascular Diseases - June 26, 2022 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
Modeling of mitochondrial bioenergetics and autophagy impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells
CONCLUSIONS: Our studies demonstrate that the MELAS iPSC-derived disease models are powerful tools for dissecting the molecular mechanisms by which mitochondrial DNA alterations influence RPE function in aging and macular degeneration, and for testing novel therapeutics in patients harboring the MELAS genotype.PMID:35715869 | DOI:10.1186/s13287-022-02937-6
Source: Cell Research - June 17, 2022 Category: Cytology Authors: Sujoy Bhattacharya Jinggang Yin Weihong Huo Edward Chaum Source Type: research
Sensors, Vol. 22, Pages 4310: Cardiovascular Disease Diagnosis from DXA Scan and Retinal Images Using Deep Learning
In this study, we aimed at diagnosing CVD using a novel approach integrating information from retinal images and DXA data. We considered an adult Qatari cohort of 500 participants from Qatar Biobank (QBB) with an equal number of participants from the CVD and the control groups. We designed a case-control study with a novel multi-modal (combining data from multiple modalities—DXA and retinal images)—to propose a deep learning (DL)-based technique to distinguish the CVD group from the control group. Uni-modal models based on retinal images and DXA data achieved 75.6% and 77.4% accuracy, respective...
Source: Sensors - June 7, 2022 Category: Biotechnology Authors: Hamada R. H. Al-Absi Mohammad Tariqul Islam Mahmoud Ahmed Refaee Muhammad E. H. Chowdhury Tanvir Alam Tags: Article Source Type: research
Acute ischemic stroke in young women secondary to atherosclerosis: a unique ophthalmic presentation with central retinal artery occlusion: a case report
We report a rare case of a young 33-year-old woman who presented an atypical ischemic stroke revealed by a unilateral CRAO. This case reports a rare condition affecting a young patient, and highlights the interest of ophthalmologic examination in the diagnostic of a neuro disease and the early management of ischemic stroke.PMID:35655682 | PMC:PMC9120742 | DOI:10.11604/pamj.2022.41.189.33147
Source: Atherosclerosis - June 3, 2022 Category: Cardiology Authors: Salma Moutamani Taha Boutaj Amine Ennejjar Wiame Touil Abdellah Amazouzi Ouafa Cherkaoui Source Type: research
Toku Eyes launches AI retinal health scanner in the US
The AI platform can predict a person ' s risk of having a stroke or a heart attack in the next five years.
Source: mobihealthnews - June 1, 2022 Category: Information Technology Source Type: news
Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model
AbstractCerebral small vessel disease (SVD) is the leading cause of vascular dementia, causes a quarter of strokes, and worsens stroke outcomes. The disease is characterised by patchy cerebral small vessel and white matter pathology, but the underlying mechanisms are poorly understood. This microvascular and tissue damage has been classically considered secondary to extrinsic factors, such as hypertension, but this fails to explain the patchy nature of the disease, the link to endothelial cell (EC) dysfunction even when hypertension is absent, and the increasing evidence of high heritability to SVD-related brain damage. We...
Source: Acta Neuropathologica - May 30, 2022 Category: Neurology Source Type: research
cRel and Wnt5a/Frizzled 5 Receptor-Mediated Inflammatory Regulation Reveal Novel Neuroprotectin D1 Targets for Neuroprotection
Cell Mol Neurobiol. 2022 May 27. doi: 10.1007/s10571-022-01231-6. Online ahead of print.ABSTRACTWnt5a triggers inflammatory responses and damage via NFkB/p65 in retinal pigment epithelial (RPE) cells undergoing uncompensated oxidative stress (UOS) and in experimental ischemic stroke. We found that Wnt5a-Clathrin-mediated uptake leads to NFkB/p65 activation and that Wnt5a is secreted in an exosome-independent fashion. We uncovered that docosahexaenoic acid (DHA) and its derivative, Neuroprotectin D1 (NPD1), upregulate c-Rel expression that, as a result, blunts Wnt5a abundance by competing with NFkB/p65 on the Wnt5a promoter...
Source: Cellular and Molecular Neurobiology - May 27, 2022 Category: Cytology Authors: Jorgelina M Calandria Khanh V Do Sayantani Kala-Bhattacharjee Andre Obenaus Ludmila Belayev Nicolas G Bazan Source Type: research
267 When investigating stroke is a waste of time
Young stroke should alert clinicians to investigate for unusual causes.
A previously well 43-year-old Caucasian female presented with 2 days of punctuated left sided weakness and sensory inattention. MRI demonstrated multiple territory infarcts, predominantly on the right side. With no vascular risk factors, high dose steroids were commenced assuming primary angiitis of the CNS (PACNS). Blood tests including ESR, HIV, an autoimmune and thrombotic screen and blood cultures were negative. A 24-hour ECG and TOE failed to identify an embolic source, though interval MRIs plus CT angi- ography revealed evolving cerebral and sple...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Cook, S., Warner, G. Tags: Poster Presentations Source Type: research
Goldfish and crucian carp are natural models of anoxia tolerance in the retina
Comp Biochem Physiol A Mol Integr Physiol. 2022 May 23:111244. doi: 10.1016/j.cbpa.2022.111244. Online ahead of print.ABSTRACTVertebrates need oxygen to survive. The central nervous system has an especially high energy demand, so brain and retinal neurons quickly die in anoxia. But fish of the genus Carassius are exceptionally anoxia-tolerant: the crucian carp (C. carassius) can survive months without oxygen in ice-covered ponds, and the common goldfish (C. auratus) can withstand hours of anoxia at room temperature. These fish previously offered insights into anoxia tolerance in the brain, heart, and liver. Here, we advanc...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - May 26, 2022 Category: Physiology Authors: Michael W Country Michael G Jonz Source Type: research
