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Total 550 results found since Jan 2013.

Goldfish and crucian carp are natural models of anoxia tolerance in the retina
Comp Biochem Physiol A Mol Integr Physiol. 2022 May 23;270:111244. doi: 10.1016/j.cbpa.2022.111244. Online ahead of print.ABSTRACTVertebrates need oxygen to survive. The central nervous system has an especially high energy demand, so brain and retinal neurons quickly die in anoxia. But fish of the genus Carassius are exceptionally anoxia-tolerant: the crucian carp (C. carassius) can survive months without oxygen in ice-covered ponds, and the common goldfish (C. auratus) can withstand hours of anoxia at room temperature. These fish previously offered insights into anoxia tolerance in the brain, heart, and liver. Here, we ad...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - May 26, 2022 Category: Physiology Authors: Michael W Country Michael G Jonz Source Type: research

Central Retinal Artery Occlusion: Current Practice, Awareness and Prehospital Delays in Switzerland
ConclusionsCRAO awareness of the general population and physician awareness about the treatment options as well as the non-standardized prehospital organization, seems to be the main reason for the prehospital delays and impedes treating CRAO patients. Educational efforts should be undertaken to improve awareness about CRAO.
Source: Frontiers in Neurology - May 23, 2022 Category: Neurology Source Type: research

Isolated and Combined Unilateral Central Retinal Artery and Vein Occlusions After Vaccination. A Review of the Literature
Retinal artery occlusion (RAO), especially central RAO, is a sight-threatening and potentially blinding ophthalmic emergency. Recent publications reported its association with coronavirus disease 2019 (COVID-19) mRNA vaccines. Although rare, vaccines have been linked to ophthalmic complications, and it is of interest to examine the current literature on vaccine-related RAO.
Source: Journal of Stroke and Cerebrovascular Diseases - May 12, 2022 Category: Neurology Authors: Clarice, Kai-ying Su, Sunny, Chi Lik Au Tags: Short Communication Source Type: research

The Port Delivery System with ranibizumab: a new paradigm for long-acting retinal drug delivery
Drug Deliv. 2022 Dec;29(1):1326-1334. doi: 10.1080/10717544.2022.2069301.ABSTRACTThe Port Delivery System with ranibizumab (PDS) is an innovative intraocular drug delivery system designed for the continuous delivery of ranibizumab into the vitreous for 6 months and beyond. The PDS includes an ocular implant, a customized formulation of ranibizumab, and four dedicated ancillary devices for initial fill, surgical implantation, refill-exchange, and explantation, if clinically indicated. Ranibizumab is an ideal candidate for the PDS on account of its unique physicochemical stability and high solubility. Controlled release is a...
Source: Drug Delivery - May 2, 2022 Category: Drugs & Pharmacology Authors: Shrirang V Ranade Mark R Wieland Tammy Tam Jennifer C Rea Judit Horvath Aaron R Hieb Weitao Jia Lori Grace Giulio Barteselli Jay M Stewart Source Type: research

Peg-leg arterioles: an adaptation to chronic retinal hypoperfusion
Conclusion: Chronic severe retinal hypoperfusion due to profound carotid occlusive disease can lead to adaptive remodeling of the retinal vasculature in a pattern that closely resembles the iconic image of a pirate's peg leg.
Source: Retinal Cases and Brief Reports - May 1, 2022 Category: Opthalmology Tags: Case Report Source Type: research

What the Science Says About the Health Benefits of Vitamins and Supplements
From multivitamins and melatonin to fiber and fish oil, Americans who are trying to boost their health and immunity have a plethora of supplements to choose from. An estimated 58% of U.S. adults ages 20 and over take dietary supplements, according to the U.S. Centers for Disease Control and Prevention, and the supplement industry is valued at more than $30 billion a year. Supplement use has been growing rapidly over the past few decades along with the wellness industry. “The popular belief is that a supplement is going to be helpful for promoting health,” says Fang Fang Zhang, a professor at Tufts University&rs...
Source: TIME: Health - April 28, 2022 Category: Consumer Health News Authors: Sandeep Ravindran Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news

Central Retinal Artery Occlusion Is Related to Vascular Endothelial Injury and Left Ventricular Diastolic Dysfunction
J Clin Med. 2022 Apr 18;11(8):2263. doi: 10.3390/jcm11082263.ABSTRACTCentral retinal artery occlusion (CRAO) is an emergency state characterized by sudden, painless vision impairment. Patients with CRAO have an increased risk of cardiovascular events, including stroke, likely related to vascular endothelial damage. Therefore, we investigated flow-mediated dilatation (FMD) of the brachial artery as a marker of endothelial dysfunction, intima-media complex thickness (IMT) of the common carotid artery, pointing to the arterial wall atherosclerotic alteration, and transthoracic echocardiographic parameters in 126 consecutive C...
Source: Atherosclerosis - April 23, 2022 Category: Cardiology Authors: Jerzy Dropi ński Rados ław Dziedzic Agnieszka Kubicka-Trz ąska Bo żena Romanowska-Dixon Teresa Iwaniec Lech Zar ęba Jan G Bazan Agnieszka Padjas Stanis ława Bazan-Socha Source Type: research

Retinal parameters, cortical cerebral microinfarcts and their interaction with cognitive impairment
Conclusions: Retinal vascular and neuronal parameters are associated with cortical CMIs and persons with both pathologies are likely to have cognitive impairment. Further studies may be warranted to evaluate the clinical utility of retinal parameters and CMI in risk prediction for cognitive dysfunction.Data access statement: The data that support the findings of this study is available from the corresponding author upon request.PMID:35450485 | DOI:10.1177/17474930221097737
Source: Atherosclerosis - April 22, 2022 Category: Cardiology Authors: Saima Hilal Carol Y Cheung Tien Yin Wong Leopold Schmetterer Christopher Chen Source Type: research

Serum sortilin as a predictor of stroke in patients with intermediate carotid artery stenosis
CONCLUSIONS: Serum sortilin level is increased in the presence of symptomatic intermediate CAS and may have clinical value in the management of patients with carotid artery disease.PMID:35403511 | DOI:10.1177/17085381211067051
Source: Atherosclerosis - April 11, 2022 Category: Cardiology Authors: Zeki Şimsek Elnur Alizade İlahe Abdurahmanova Ahmet G üner Regayip Zehir Sel çuk Pala Source Type: research

Retinal vein occlusion is associated with stroke independent of underlying cardiovascular disease
Eye, Published online: 11 April 2022; doi:10.1038/s41433-022-02038-xRetinal vein occlusion is associated with stroke independent of underlying cardiovascular disease
Source: Eye - April 11, 2022 Category: Opthalmology Authors: Christine Y. Bakhoum Samantha Madala Christopher K. Long Fatemeh Adabifirouzjaei William R. Freeman Michael H. Goldbaum Anthony N. DeMaria Mathieu F. Bakhoum Source Type: research

Prevalence and associated relating factors in patients with hereditary retinal dystrophy: a nationwide population-based study in Taiwan
CONCLUSIONS: 74% of the diagnosed HRD are retinitis pigmentosa. Population-based data suggested an increased incidence of cataract in younger patients, whereas older HRD patients are more susceptible to develop CME. Further work is needed to elucidate the mechanism between these ophthalmological disorders and HRD.PMID:35396285 | DOI:10.1136/bmjopen-2021-054111
Source: Cancer Control - April 9, 2022 Category: Cancer & Oncology Authors: Peng Yeong Woon Jia-Ying Chien Jen-Hung Wang Yu-Yau Chou Mei-Chen Lin Shun-Ping Huang Source Type: research