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Total 550 results found since Jan 2013.

GSE223628 Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate (bulk)
Contributors : Jie Ding ; Kanako Yuki ; Calvin KuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDerangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/ -catenin signaling, which is essential for BBB and BRB function. However, systemic pharmacologic FZD4 stimulation is hindered by obligate palmitoylation and insolubility of native WNTs and suboptimal properties of the FZD4-selective ligand Norrin. Here, we developed L6-F...
Source: GEO: Gene Expression Omnibus - January 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE223498 Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate
Contributors : Jie Ding ; Lukas Vlahos ; Vincent van Unen ; Kanako Yuki ; Calvin KuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDerangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/ -catenin signaling, which is essential for BBB and BRB function. However, systemic pharmacologic FZD4 stimulation is hindered by obligate palmitoylation and insolubility of native WNTs and suboptimal properties of the FZD4-selective liga...
Source: GEO: Gene Expression Omnibus - January 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Sleep disordered breathing has minimal association with retinal microvascular diameters in a non-diabetic sleep clinic cohort
ConclusionNo major SDB associations with CRAE or CRVE were identified, although the RFM/CPAP intervention reduced evening CRVE for severe OSA patients. Implications for cerebro-vascular disease risk remain uncertain. Trial registrationThe protocol was registered with the Australian New Zealand Clinical Trials Registry (Trial Id: ACTRN12620000694910).
Source: PLoS One - January 10, 2023 Category: Biomedical Science Authors: Kristina Kairaitis Source Type: research

Differences in retinal microvasculature between large artery atherosclerosis and small artery disease: an optical coherence tomography angiography study
Conclusions: We found LAA patients had significantly reduced DVC density compared with SAD; we also showed anterior LAA patients had significantly reduced SVC density compared with posterior LAA. These findings suggest retinal imaging has the potential to be used to detect microvasculature changes in subtypes of ischemic stroke.PMID:36620764 | PMC:PMC9816383 | DOI:10.3389/fnagi.2022.1053638
Source: Atherosclerosis - January 9, 2023 Category: Cardiology Authors: Kun Lu William Robert Kwapong Shuai Jiang Xuening Zhang Jianyang Xie Chen Ye Yuying Yan Le Cao Yitian Zhao Bo Wu Source Type: research

Retinal age gap as a predictive biomarker of stroke risk
The aim of this study is to investigate the association of retinal age gap with the risk of incident stroke and its predictive value for incident stroke.
Source: BMC Medicine - November 30, 2022 Category: Internal Medicine Authors: Zhuoting Zhu, Wenyi Hu, Ruiye Chen, Ruilin Xiong, Wei Wang, Xianwen Shang, Yifan Chen, Katerina Kiburg, Danli Shi, Shuang He, Yu Huang, Xueli Zhang, Shulin Tang, Jieshan Zeng, Honghua Yu, Xiaohong Yang & hellip; Tags: Research article Source Type: research

Elevated TGF β Signaling Contributes to Cerebral Small Vessel Disease in Mouse Models of Gould Syndrome
CONCLUSIONS: This study identifies a novel biological role for collagen α1α1α2(IV) as a regulator of TGFβ signaling and demonstrates that elevated TGFβ signaling contributes to CNS vascular pathologies caused by Col4a1 mutations. Our findings suggest that pharmacologically suppressing TGFβ signaling could reduce the severity of CSVD, and potentially other manifestations associated with Gould syndrome and have important translational implications that could extend to idiopathic forms of CSVD.PMID:36435425 | DOI:10.1016/j.matbio.2022.11.007
Source: Matrix Biology - November 26, 2022 Category: Molecular Biology Authors: Kayla Branyan Cassandre Labelle-Dumais Xiaowei Wang Genki Hayashi Bryson Lee Zoe Peltz Se án Gorman Bo Qiao Li Mao Mao Douglas B Gould Source Type: research

Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke
Conclusion RV offers an alternative predictive biomarker to traditional risk-scores for vascular health, without the need for blood sampling or blood pressure measurement. Further work is needed to examine RV in population screening to triage individuals at high-risk.
Source: British Journal of Ophthalmology - November 22, 2022 Category: Opthalmology Authors: Rudnicka, A. R., Welikala, R., Barman, S., Foster, P. J., Luben, R., Hayat, S., Khaw, K.-T., Whincup, P., Strachan, D., Owen, C. G. Tags: Open access, Editor's choice, Press releases Original articles - Clinical science Source Type: research

Purtscher-Like Retinopathy with Cardioembolic Stroke: Case Report and Literature Review
We present a case of PUR associated with a cardioembolic stroke in a patient following temporary cessation of anticoagulant therapy for a surgical procedure. Our patient presented with multiple risk factors for PUR and classic signs and symptoms including multiple peripapillary white retinal lesions near arterioles and sudden unilateral decrease in visual acuity. Optical coherence tomography showed inner retinal hyperreflectivity and thinning consistent with inner retinal ischemia, and fluorescein angiography showed delayed retinal filling. Her complement C5 factor was elevated on laboratory testing. Brain magnetic resonan...
Source: Case Reports in Ophthalmology - November 17, 2022 Category: Opthalmology Source Type: research

Risk factors for ischemic cerebral stroke in patient with acute amaurosis fugax
CONCLUSION: Ischemic stroke and myocardial infarction were diagnosed in 0.3%-0.9% of hospitalized acute AF cases. Presence of hypercoagulable state, systemic vasculitis, CAD, and atherosclerosis each individually increased the risk of ischemic stroke by more than 3-fold; patients with these risk factors and acute AF should be closely monitored for developing acute systemic thrombotic events.PMID:36368408 | DOI:10.1016/j.jcjo.2022.10.010
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Tony Y Chen Aditya Uppuluri Owais Aftab Marco Zarbin Nathan Agi Neelakshi Bhagat Source Type: research