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Condition: Diabetes Mellitus
Drug: Insulin

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Total 394 results found since Jan 2013.

Which cardiovascular diseases are most influenced by smoking - a cohort retrospective study
Conclusion: This study suggests that smoking may have a greater impact on the development of stroke (p = 0.012) and HBP (p = 0.025). Smoking also has an impact on the development of AMI, but on a smaller scale (p=0.042). Higher PY values are also influencing the development of CVD (p = 0.035). There was no statistically significant variation between the two groups in the development of DM2.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Carvalho Cordes Amaral Barata, C., Rosa, R., Vieira, A. C., Ferra, J., Fradinho, M., Matos, C., Nogueira, F. Tags: Tobacco, smoking control and health educ. Source Type: research

Extrarenal manifestations of the hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC HUS)
AbstractHemolytic uremic syndrome is commonly caused by Shiga toxin-producingEscherichia coli (STEC). Up to 15% of individuals with STEC-associated hemorrhagic diarrhea develop hemolytic uremic syndrome (STEC HUS). Hemolytic uremic syndrome (HUS) is a disorder comprising of thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney injury. The kidney is the most commonly affected organ and approximately half of the affected patients require dialysis. Other organ systems can also be affected including the central nervous system and the gastrointestinal, cardiac, and musculoskeletal systems. Neurological complicat...
Source: Pediatric Nephrology - October 29, 2019 Category: Urology & Nephrology Source Type: research

In vitro antioxidant, š¯›¼-amylase and š¯›¼-glucosidase activities of methanol extracts from three Momordica species
AbstractAntioxidant based drug preparations are used in the prevention and management of complex diseases which include atherosclerosis, stroke, diabetes, alzheimer ā€™s disease and cancer. Diabetes mellitus is a metabolic disorder of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this ailment, which may be achieved through the use of oral hypoglycemic drugs such as biguanides, insulin secretagogues, and š¯›¼-amyla se and glucosidase inhibitors. Although several biological activities had been reported forĀ MomordicafoetidaandMomordicacharantia; it appears there is limited info...
Source: International Journal of Phytomedicine - August 25, 2019 Category: Science Authors: Olubunmi Adenike Akinwunmi Source Type: research

In vitro antioxidant, Ī±-amylase and Ī±-glucosidase activities of methanol extracts from three Momordica species
AbstractAntioxidant based drug preparations are used in the prevention and management of complex diseases which include atherosclerosis, stroke, diabetes, alzheimer ā€™s disease and cancer. Diabetes mellitus is a metabolic disorder of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this ailment, which may be achieved through the use of oral hypoglycemic drugs such as biguanides, insulin secretagogues, and š¯›¼-amyla se and glucosidase inhibitors. Although several biological activities had been reported forĀ MomordicafoetidaandMomordicacharantia; it appears there is limited info...
Source: International Journal of Phytomedicine - August 25, 2019 Category: Science Authors: Oubunmi Adenike Akinwunmi Source Type: research

Subclinical Atherosclerosis in Young Adult Population with First Degree Relatives of Type 2 Diabetes Mellitus.
Authors: Abdaly MS, Azizi MS, Wijaya IP, Nugroho P, Purnamasari D Abstract Cardiovascular disease (CVD) remain a leading cause of death globally. The concept of acute myocardial infarction in young adults was uncommon. Atherosclerosis is the leading cause of CVD, including myocardial infarction, stroke, heart failure and peripheral artery disease. This condition is initiated early in childhood and progressive in nature. CVD risk factors includes hypertension, dyslipidemia and obesity play a role in the development of atherosclerosis andĀ  components in insulin resistance syndrome.One of many risk factors for insuli...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Mir-206 Deficiency Results In A Favorable Phenotype: Relevance For Type-2 Diabetes Mellitus And Metabolic Syndrome
Background and Aims: Type-2 diabetes mellitus (T2DM) and metabolic syndrome (MS) are multifactorial and multigenic diseases and hallmarks for atherosclerosis and stroke. Characteristics of these diseases include glucose intolerance, insulin resistance, hypertension, and disorders in triglyceride and cholesterol metabolism. Despite intensive research in this area, major factors liable for T2DM and MS and in turn for treatment are still elusive.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: G. Kostner, N. Vujic, D. Kratky Tags: Posters 26 - 29 May, 2019 Source Type: research

Macro- and micro-vascular complications and their determinants among people with type 2 diabetes in Bangladesh
ConclusionDiabetes complications are highly prevalent among type 2 diabetes population in Bangladesh. Prevention strategies should focus on increasing physical activity, weight loss, smoking cessation, and more strict control of hypertension and glycaemic level.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 1, 2019 Category: Endocrinology Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease
Conclusion: Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the intracranial carotid artery is most frequently affected. Intracranial arterial calcifications might be associated with imaging markers of SVD and are highly correlated with WMHs, lacunes, and CMBs. Quantification of calcification on CT provides additional information on the pathophysiology of SVD. Intracranial arterial calcification could act as a potential marker of SVD. Introduction Atherosclerosis is a systemic vascular process that is considered a major cause of cerebrovascular and cardiovascular di...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 Ī² Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

Association of C-peptide with diabetic vascular complications in type 2 diabetes.
CONCLUSION: -: C-peptide was positively associated with CVD, but inversely associated with DR progression. The association between C-peptide and CVD could be due to associated metabolic risk factors. PMID: 31026551 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - April 22, 2019 Category: Endocrinology Authors: Wang Y, Wan H, Chen Y, Xia F, Zhang W, Wang C, Fang S, Zhang K, Li Q, Wang N, Lu Y Tags: Diabetes Metab Source Type: research

The relation between echocardiographic epicardial fat thickness and mitral annular calcification
Conclusion: We showed that EFT was significantly elevated in patients with MAC and it was positively correlated with MAC.Keywords: mitral annular calcification, epicardial fat thickness, cardiovascular risk.
Source: African Health Sciences - April 17, 2019 Category: African Health Source Type: research

Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus.
CONCLUSIONS: There is inconclusive evidence whether M+S combination therapy compared with metformin plus another glucose-lowering intervention results in benefit or harm for most patient-important outcomes (mortality, SAEs, macrovascular and microvascular complications) with the exception of hypoglycaemia (more harm for M+S combination). No RCT reported on health-related quality of life. PMID: 30998259 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - April 17, 2019 Category: General Medicine Authors: Madsen KS, KƤhler P, KƤhler LKA, Madsbad S, Gnesin F, Metzendorf MI, Richter B, Hemmingsen B Tags: Cochrane Database Syst Rev Source Type: research