Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts

Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health problem. Atrial fibrillation (AF), affects 1–3% of the developed world population. This prevalence will likely increase to ∼9 and ∼18 million cases in the United States and Europe, respectively, by 2060 (Miyasaka et al., 2006). Chronic AF increases incidences of both morbidity, often as stroke, and all-cause mortality. Age is a major risk factor for AF, affecting 0.1, 4, and 20% of individuals aged 80 years, respectively. So are metabolic factors, arising from physical inactivity, obesity, diabetes mellitus, and metabolic syndrome. Themselves age-dependent, these account for ∼60% of current upward trends in AF incidence (Miyasaka et al., 2006). Both age and metabolic deficiency in turn are associated with mitochondrial dysfunction (Vianna et al., 2006). Age is associated with mitochondrial DNA damage and compromised respiratory chain function (...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

Related Links:

Source: European Journal of Sport Science - Category: Sports Medicine Authors: Source Type: research
Source: Biological Rhythm Research - Category: Research Authors: Source Type: research
Source: Biological Rhythm Research - Category: Research Authors: Source Type: research
Source: Biological Rhythm Research - Category: Research Authors: Source Type: research
Source: Biological Rhythm Research - Category: Research Authors: Source Type: research
Source: Biological Rhythm Research - Category: Research Authors: Source Type: research
Ranging from the skin to liver, body has an in-built detox system that keeps it running smoothly on a daily basis. Due to the present life-style, increased stress, pollution, unhealthy dietary habits, the natural system gets weakened. The need of present time is to unveil the herbs present in the nature full of detox potential, inheriting the capacity to purify the kidney, liver, gut, skin and blood. These herbal detoxifiers facilitate lungs, aids kidneys, facilitates digestive tract and skin. The present review deals with the study of herbs under the category of detoxifiers for kidney, liver, gut, skin and blood. The herb...
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: Food preferences are acquired in childhood and sound nutritional practices should be established in childhood to prevent lifestyle disorders and premature aging. Though CR is a known and preferred non-pharmacological intervention in the management of obesity, its implemention has not been explored and evaluated extensively. This is a vital area that needs scientific research as the goals of obesity managements are no longer just weight loss through dietary restrictions. An interdisciplinary method to lifestyle modification in the management of adolescent obesity addressing all physiological and psychosocial aspects is recommended.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: It can be concluded that the concentration of κ-carrageenan and starch strongly influenced the rheological and textural properties of dairy desserts, whereas the inulin content had little effect on these attributes.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: Cooking methods alter the composition of non-digestible fibers in soybean, and this can result in the lack of fermentative particles in the feces, thereby causing alterations in the breath level of hydrogen via colonic fermentation.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
More News: Academia | Anesthesia | Anesthesiology | Arrhythmia | Atrial Fibrillation | Atrial Septal Defect | Avandia | Biochemistry | Biology | Brain | Calcium | Canada Health | Cardiac Arrhythmia | Cardiology | Cardiomyopathy | China Health | Cytology | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Education | Electrocardiogram | Endocrinology | Environmental Health | Fenofibrate | Genetics | Grants | Heart | Heart Failure | High Fat | Hole in the Heart | Hong Kong Health | Hypertrophic Cardiomyopathy | Insulin | International Medicine & Public Health | Ireland Health | Laboratory Medicine | Liver | Malaysia Health | Medical Ethics | Metabolic Syndrome | Mitochondria | Molecular Biology | Netherlands Health | Neurology | Neuroscience | Neurosurgery | Nutrition | Obesity | Obstructive Sleep Apnea | Physiology | Potassium | Reproduction Medicine | Research | Respiratory Medicine | Royal College of Surgeons | Sleep Apnea | Sleep Disorders | Sleep Medicine | Sodium | Sports Medicine | Statistics | Stroke | Students | Study | Tricor | UK Health | Universities & Medical Training | Urology & Nephrology | USA Health | Vitamin A