Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts

Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health problem. Atrial fibrillation (AF), affects 1–3% of the developed world population. This prevalence will likely increase to ∼9 and ∼18 million cases in the United States and Europe, respectively, by 2060 (Miyasaka et al., 2006). Chronic AF increases incidences of both morbidity, often as stroke, and all-cause mortality. Age is a major risk factor for AF, affecting 0.1, 4, and 20% of individuals aged 80 years, respectively. So are metabolic factors, arising from physical inactivity, obesity, diabetes mellitus, and metabolic syndrome. Themselves age-dependent, these account for ∼60% of current upward trends in AF incidence (Miyasaka et al., 2006). Both age and metabolic deficiency in turn are associated with mitochondrial dysfunction (Vianna et al., 2006). Age is associated with mitochondrial DNA damage and compromised respiratory chain function (...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Publication date: Available online 17 August 2019Source: Revista Clínica Española (English Edition)Author(s): J. Masip, J.R. Germà LluchAbstractRecent epidemiological studies have shown that alcohol consumption can increase the risk of arterial hypertension, atrial fibrillation and gastrointestinal and breast cancer. Various sectors are therefore promoting abstinence from alcohol. However, light alcohol consumption has once again been shown to reduce the risk of myocardial infarction and diabetes but with an unclear effect on cerebrovascular disease. The decision to consume alcohol should therefore be ...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
ConclusionOnly a few cases of penile FG have been reported. Early debridement of all necrotic tissue is the golden rule.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionThis report described the presentation and treatment of a chronic S. marcescens sternal abscess that occurred 13 years after CABG. Chronic sternal infections due to this organism in cardiac surgery patients are exceeding rare.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 10 August 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): M. Compagnat, S. Mandigout, C.S. Batcho, N. Vuillerme, J.Y. Salle, R. David, J.C. DavietAbstractBackgroundRecent studies reported that wearable sensor devices show low validity for assessing the amount of energy expenditure in individuals after stroke.ObjectiveWe aimed to evaluate the validity of energy expenditure calculation based on the product of energy cost and walked distance estimated by wearable devices in individuals after hemispheric stroke.MethodsWe recruited individuals with hemispheric stroke seque...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
ConclusionsThese findings suggest that darkerskinned Latinx children may be at increased risk for more severe and/or more persistent mental health problems, perhaps due to discrimination based on their skin color. In order to develop intervention strategies to prevent mental health problems in the Latinx child population, future research is needed to examine how racism may manifest, particularly in teacher-student and parent-child interactions, in the everyday experiences of young children.
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
This study aimed to develop a short form of the Diabetes Acceptance and Action Scale that would be suitable for administration across all ages.MethodPeople with diabetes were recruited via social media, support organisations and charities as well as clinical services. They completed an online survey measuring demographic and clinical data, the Diabetes Acceptance &Action Scale, Problems in Diabetes Short Form, Self-Care Inventory Revised, Brief Experiential Avoidance Questionnaire, Cognitive Fusion Questionnaire and Engaged Living Scale.ResultsFive hundred and thirty-one participants with diabetes responded to the onli...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
Authors: Bilezikian JP, Hattersley G, Mitlak BH, Hu MY, Fitzpatrick LA, Dabrowski C, Miller PD, Papapoulos SE Abstract Objective: To evaluate, post hoc, the efficacy and safety of abaloparatide by degree of renal impairment. Methods: ACTIVE was a phase 3, 18-month, randomized, double-blind, active-comparator, placebo-controlled study of postmenopausal women with osteoporosis who received subcutaneous abaloparatide 80 µg, placebo, or open-label teriparatide 20 µg daily. Patients with serum creatinine>2.0 mg/dL or 1.5-2.0 mg/dL with an estimated glomerular filtration rate (eGFR)
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
ConclusionWe found no evidence that Donders contracted leprosy despite years of intense leprosy contact, but we successfully isolated an archaeological M. leprae aDNA sample from a control skeleton from South America.SignificanceWe successfully genotyped recovered aDNA to a M. leprae strain that likely originated in West Africa. The detected human mitochondrial haplogroup L3 is also associated with this geographical region. This suggests that slave trade contributed to leprosy in Suriname.LimitationsA limited number of skeletons was examined.Suggestions for further researchBroader review of skeletal collections is advised ...
Source: International Journal of Paleopathology - Category: Pathology Source Type: research
ConclusionThe incidence of early poststroke seizures was overall rare, and no significant differences emerged between patients receiving and those not receiving reperfusion therapies.This article is part of the Special Issue “Seizures and Stroke”.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 17 August 2019Source: Epilepsy &BehaviorAuthor(s): Rhys H. Thomas, Karen OslandAbstractThe Epilepsy Deaths Register (EDR) differs from typical registries which concentrate primarily on clinical information. It is completed by bereaved relatives and focuses on the circumstances immediately before, and the support following, a death. It can be augmented by copies of death certificates from the families of the deceased, and all epilepsy associated deaths can be entered. The EDR is underpinned by the research and experience of the SUDEP Action team and the clinical advisors who helped des...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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