In vitro antioxidant, α-amylase and α-glucosidase activities of methanol extracts from three Momordica species

AbstractAntioxidant based drug preparations are used in the prevention and management of complex diseases which include atherosclerosis, stroke, diabetes, alzheimer ’s disease and cancer. Diabetes mellitus is a metabolic disorder of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this ailment, which may be achieved through the use of oral hypoglycemic drugs such as biguanides, insulin secretagogues, and 𝛼-amyla se and glucosidase inhibitors. Although several biological activities had been reported for MomordicafoetidaandMomordicacharantia; it appears there is limited information on the   biological activity ofMomordicacissoides. The purpose of this study is to compare the antioxidant, 𝛼-amylase and 𝛼-glucosidase inhibitory activities ofMomordicacharantia(M1),Momordicafoetida(M2),andMomordicacissoides  (M3) to establish a chemotaxonomic relationship between them. The antioxidant activities measured by DPPH scavenging properties, metal ion chelation, hydrogen peroxide scavenging and ABTS revealed thatM. foetida had the highest inhibition potential, followed byM. charantia and the least beingM. cissoides. In contrast, the antioxidant activities measured by FRAP,   the total phenolic content , flavonoids and tannins revealed thatM. cissoides had the best antioxidant potential, whileM. foetida had the least activity. The comparative α-amylase and glucosidase inhibitory studies performed demonstrated that that the extrac...
Source: International Journal of Phytomedicine - Category: Science Authors: Source Type: research