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Total 656 results found since Jan 2013.
Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Yan He, Xiaoming Yuan, Hao Zuo, Xiangwei Li, Ying Sun, Aiwen FengAbstractAimsThe present study investigated if berberine might induce Zrt-Irt-like protein 14 (ZIP14) and affect zinc redistribution to protect intestinal barrier in sepsis.Main methodsRodent model of sepsis was induced by cecal ligation and puncture (CLP). Plasma endotoxin was assayed by LAL test and plasma zinc was measured by flame atomic spectrophotometer. Gut mucosal permeability was determined by plasma FITC-dextran. Zinc content and ZIP14 mRNA in gut mucosa were assayed by sp...
Source: Life Sciences - July 31, 2019 Category: Biology Source Type: research
Litopenaeus vannamei Src64B restricts white spot syndrome virus replication by modulating apoptosis
In conclusion, the current data strongly suggest that Src64B is a host factor that inhibits WSSV replication by modulating apoptosis in shrimp.
Source: Fish and Shellfish Immunology - July 28, 2019 Category: Biology Source Type: research
Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury.
Conclusions: TL potentiate ROS by mitochondria which activate mitochondrial oxidative stress, decrease ATP production, increase mitochondrial proton leak and glycolysis rate, and mitochondria DNA damage. Additionally, CPT1A1 siRNA knockdown suppresses oxidative stress and prevents mitochondrial dysfunction and vascular inflammation in TL treated HBMECs. TL activates ATF3-MAPKinase, TNF, and NRF2 signaling pathways. Furthermore, the NRF2 signaling pathway which is upstream of the ATF3-MAPKinase signaling pathway, is also regulated by the mitochondrial oxidative stress. We are the first to report differential inflammatory ch...
Source: Free Radical Biology and Medicine - July 25, 2019 Category: Biology Authors: Nyunt T, Britton M, Wanichthanarak K, Budamagunta M, Voss JC, Wilson DW, Rutledge JC, Aung HH Tags: Free Radic Biol Med Source Type: research
The effects of Tel2 on cardiomyocyte survival
Publication date: 1 September 2019Source: Life Sciences, Volume 232Author(s): Naaiko Yorichika, Yuichi Baba, Briana K. Shimada, Manoj Thakore, Sharon M. Wong, Motoi Kobayashi, Jason K. Higa, Takashi MatsuiAbstractAimsOverexpression of the mechanistic target of rapamycin (mTOR), a member of the PIKK (phosphoinositide kinase-related kinase) family, protects cardiomyocytes from cell death induced by pathological stimuli such as ischemia. We previously reported that posttranslational modification of mTOR plays an important role in regulating cardiac mTOR expression. The aim of this study was to see if Tel2 (telomere maintenanc...
Source: Life Sciences - July 25, 2019 Category: Biology Source Type: research
S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
This study provides insights on the potential of CySSPe as an onion-derived dietary agent that modulates redox homeostasis and combats oxidative stress.
PMID: 31349040 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - July 22, 2019 Category: Biology Authors: Tocmo R, Parkin K Tags: Free Radic Biol Med Source Type: research
MicroRNA-92b-3p suppresses angiotensin II-induced cardiomyocyte hypertrophy via targeting HAND2
In this study, we want to investigate the role of microRNA-92b-3p (miR-92b-3p) in cardiomyocyte hypertrophy and the mechanisms involved.Materials and methodsNeonatal mouse ventricular cells (NMVCs) were isolated from the hearts of 1–3-d-old newborn C57BL6 mice. The isolated NMVCs were induced hypertrophic phenotype by Angiotensin-II (Ang-II) and the cell size was examined by FITC-phalloidin staining assay. The expression of miR-92b-3p was determined by quantitative real-time PCR (qRT-qPCR). MRNA and protein level of β-MHC, ACTA1 and HAND2 in NMVCs transfected with miR-92b-3p mimic and inhibition were assessed by RT-qPCR...
Source: Life Sciences - July 6, 2019 Category: Biology Source Type: research
Calpain silencing alleviates myocardial ischemia-reperfusion injury through the NLRP3/ASC/Caspase-1 axis in mice
Publication date: Available online 3 July 2019Source: Life SciencesAuthor(s): Rong-Chuan Yue, Sheng-Zhong Lu, Yu Luo, Tao Wang, Hao Liang, Jing Zeng, Jie Liu, Hou-Xiang HuAbstractAimsPrior to reperfusion, Calpains remain inactive due to the acidic pH and elevated ionic strength in the ischemic myocardium; but Calpain is activated during myocardial reperfusion. The underlying mechanism of Calpain activation in the ischemia-reperfusion (I/R) is yet to be determined. Therefore, the present study aims to investigate the mechanism of Calpain in I/R-induced mice.Main methodsIn order to detect the function of Calpain and the NLRP...
Source: Life Sciences - July 4, 2019 Category: Biology Source Type: research
Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1 α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE.
In conclusion, our data demonstrated that ghrelin reduced oxidative stress injury and neuronal apoptosis which was in part via the GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 signalling pathway after HI. Ghrelin may be a novel therapeutic target for treatment after neonatasl HI injury.
PMID: 31279091 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - July 2, 2019 Category: Biology Authors: Huang J, Liu W, Doycheva DM, Gamdzyk M, Lu W, Tang J, Zhang JH Tags: Free Radic Biol Med Source Type: research
Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration
Publication date: Available online 26 June 2019Source: Life SciencesAuthor(s): Yuelong Huang, Ying Wang, Chengai Wu, Wei TianAbstractHeadings aimsThe present study determined whether nucleus pulposus (NP) cells express hypoxia-inducible factor-2alpha (HIF-2α) and assessed its role in regulating the expression of catabolic factors during intervertebral disc degeneration.Materials and methodsHuman degenerated NP tissues were acquired to examine the HIF-2α expression levels using immunohistochemistry, western blotting, and Real-time PCR. Human NP cells were cultivated under normoxic or hypoxic conditions, and the HIF-2α ex...
Source: Life Sciences - June 26, 2019 Category: Biology Source Type: research
Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis
ConclusionHispidulin is a neuroprotective agent with clinical potential against IR-induced neurological injury.
Source: Life Sciences - June 25, 2019 Category: Biology Source Type: research
BmSd gene regulates the silkworm wing size by affecting the Hippo pathway
This article is protected by copyright. All rights reserved
Source: Insect Science - June 20, 2019 Category: Biology Authors: Jin Yin,
Jing Zhang,
Tao Li,
Xia Sun,
Sheng Qin,
Cheng ‐Xiang Hou,
Guo‐Zheng Zhang,
Mu‐Wang Li Tags: ORIGINAL ARTICLE Source Type: research
Role of PGRMC1 in cell physiology of cervical cancer
In this study, we performed 2D-DIGE and MALDI-TOF/TOF MS to analyze differentially expressed proteins between HeLa and invasive HeLa-I5 cells..Key findingsAccording to our proteomics data, 68 differentially expressed proteins between the HeLa and HeLa-I5 cells were identified. One of these differentially expressed proteins, Progesterone receptor membrane component 1 (PGRMC1), was selected as a candidate for further studies. To correlate the role of PGRMC1 with cellular migration and cancer progression, small interfering RNA (siRNA) was used to knockdown the expression of PGRMC1. Similar function of PGRMC1 was also observed...
Source: Life Sciences - June 18, 2019 Category: Biology Source Type: research
Inhibition of Cyclophilin A on the replication of red spotted grouper nervous necrosis virus associates with multiple pro-inflammatory factors
Publication date: Available online 5 June 2019Source: Fish & Shellfish ImmunologyAuthor(s): Muhammad Asim, V. Sarath Babu, Zhendong Qin, Lijuan Zhao, Jianguo Su, Jun Li, Jiagang Tu, Hongyan Kou, Li LinAbstractCyclophilin A (CypA) is a ubiquitously expressed cellular protein and involves in diverse pathological conditions, including infection and inflammation. CypA acts as a key factor in the replication of several viruses. However, little is known about the role of CypA in the replication of the red-spotted grouper nervous necrosis virus (RGNNV). In the present report, grouper CypA (GF-CypA) was cloned from the grouper fin...
Source: Fish and Shellfish Immunology - June 6, 2019 Category: Biology Source Type: research
P120-catenin regulates pulmonary fibrosis and TGF-β induced lung fibroblast differentiation
In this study, we investigated the expression and role of P120 in pulmonary fibrosis and transforming growth factor beta (TGF-β) mediated lung fibroblast-to-myofibroblast differentiation (fibroblast differentiation). Our data indicated that P120 expression increased in lung fibrotic foci and primary lung fibroblasts isolated from bleomycin- (BLM) challenged mice, compared to controls. In vitro, TGF-β induced P120 expression in human lung fibroblasts, and siRNA-mediated SMAD3 depletion inhibited TGF-β stimulated P120 expression. Blocking nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway throu...
Source: Life Sciences - May 22, 2019 Category: Biology Source Type: research
Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer
Publication date: Available online 20 May 2019Source: Redox BiologyAuthor(s): Min Wang, Yijue Xue, Lanlin Shen, Pan Qin, Xiaolin Sang, Zhiwei Tao, Jingyan Yi, Jia Wang, Pixu Liu, Hailing ChengAbstractCervical cancer has poor prognosis and patients are often diagnosed at advanced stages of the disease with limited treatment options. There is thus an urgent need for the discovery of new therapeutic strategies in cervical cancer. The activation of SGK1 has been linked to the development of various cancer types but little is known about the role of SGK1 in cervical cancer and its potential as a therapeutic target. Here we repo...
Source: Redox Biology - May 22, 2019 Category: Biology Source Type: research
