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Total 656 results found since Jan 2013.

Sodium fluoride activates the extrinsic apoptosis via regulating NOX4/ROS-mediated p53/DR5 signaling pathway in lung cells both in vitro and in vivo
In this study, we report that death receptor 5 (DR5), a major component of the extrinsic apoptotic pathway, is markedly induced upon NaF stimulation. Enhanced DR5 induction was necessary for the apoptotic effects of NaF, inasmuch as transfected BEAS-2B cells with DR5 siRNA attenuated NaF-induced caspase-8 activation in lung cells. Mechanism investigation indicated that the induction of DR5, following NaF exposure, was mediated by tumor protein 53 (p53)-dependent transcriptional activation. Notably, we demonstrated that NaF could induce a significant increase in intracellular reactive oxygen species (ROS) level derived from...
Source: Free Radical Biology and Medicine - April 15, 2021 Category: Biology Authors: Chao Song Dongmei Shi Kaiwen Chang Xianghui Li Qing Dong Xia Ma Xuefei Wang Zhenhuan Guo Yonglu Liu Jundong Wang Source Type: research

The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons
Free Radic Biol Med. 2021 Apr 11:S0891-5849(21)00206-9. doi: 10.1016/j.freeradbiomed.2021.04.004. Online ahead of print.ABSTRACTAccumulation of senile plaques mainly composed of neurotoxic amyloid-beta peptide (Aβ) is a pathological hallmark of Alzheimer's disease (AD). Sestrin2 inducible by various types of stressors is known to promote autophagy and exert antioxidative effects. In this work, we revealed the molecular mechanisms underlying Aβ induction of sestrin2 and tested whether antioxidation, in addition to autophagy regulation, also contributes to its neuroprotective effects in primary rat cortical neurons. We fou...
Source: Free Radical Biology and Medicine - April 14, 2021 Category: Biology Authors: Yi-Heng Hsieh A-Ching Chao Yi-Chun Lin Shang-Der Chen Ding-I Yang Source Type: research

Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress
Free Radic Biol Med. 2021 Apr 6:S0891-5849(21)00195-7. doi: 10.1016/j.freeradbiomed.2021.03.035. Online ahead of print.ABSTRACTDioscin, one natural product, has various pharmacological actions. However, its effects on methotrexate (MTX)-induced hepatorenal damages still remain unknown. In the present study, the data manifested that dioscin restored the viabilities of L-02 and NRK-52E cells, reduced ALT, AST, Cr, BUN levels, and ameliorated histopathological changes of liver and kidney. Besides, dioscin decreased ROS levels in cells, and adjusted SOD, MDA, GSH and GSH-Px levels in rats. Dioscin reduced the expression levels...
Source: Free Radical Biology and Medicine - April 9, 2021 Category: Biology Authors: Y Li M Gao L-H Yin L-N Xu Y Qi Pengyuan Sun J-Y Peng Source Type: research

Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy
Publication date: Available online 28 March 2021Source: Life SciencesAuthor(s): Sepideh Mirzaei, Mohammad Hossein Gholami, Farid Hashemi, Amirhossein Zabolian, Kiavash Hushmandi, Vahid Rahmanian, Maliheh Entezari, Yarabahally R. Girish, Kothanahally S. Sharath Kumar, Amir Reza Aref, Pooyan Makvandi, Milad Ashrafizadeh, Ali Zarrabi, Haroon Khan
Source: Life Sciences - March 29, 2021 Category: Biology Source Type: research

C-C Motif Ligand 8 promotes atherosclerosis via NADPH Oxidase 2/Reactive Oxygen Species-induced endothelial permeability Increase
This study might contribute to a deeper understanding of the connection between chemokines and atherosclerosis.PMID:33741452 | DOI:10.1016/j.freeradbiomed.2021.02.022
Source: Free Radical Biology and Medicine - March 20, 2021 Category: Biology Authors: Song Xue Hanfei Tang Gefei Zhao Chao Fang Yang Shen Dong Yan Ye Yuan Weiguo Fu Zhenyu Shi Xiao Tang Daqiao Guo Source Type: research

Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems
Publication date: Available online 16 March 2021Source: Life SciencesAuthor(s): Sepideh Mirzaei, Mahmood Khaksary Mahabady, Amirhossein Zabolian, Alireza Abbaspour, Peyman Fallahzadeh, Maedeh Noori, Farid Hashemi, Kiavash Hushmandi, Salman Daneshi, Alan Prem Kumar, Amir Reza Aref, Saeed Samarghandian, Pooyan Makvandi, Haroon Khan, Michael R. Hamblin, Milad Ashrafizadeh, Ali Zarrabi
Source: Life Sciences - March 16, 2021 Category: Biology Source Type: research

Advances in siRNA delivery strategies for the treatment of MDR cancer
Publication date: Available online 11 March 2021Source: Life SciencesAuthor(s): Md Abdus Subhan, Sara Aly Attia, Vladimir P. Torchilin
Source: Life Sciences - March 11, 2021 Category: Biology Source Type: research

The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy.
Abstract Diabetic Retinopathy (DR) is a major cause of visual dysfunction, yet much remains unknown regarding the specific molecular events that contribute to diabetes-induced retinal pathophysiology. Herein, we review the impact of oxidative stress on DR, and explore evidence that supports a key role for the stress response protein regulated in development and DNA damage (REDD1) in the development of diabetes-induced oxidative stress and function defects in vision. It is well established that REDD1 mediates the cellular response to a number of diverse stressors through repression of the central metabolic regulato...
Source: Free Radical Biology and Medicine - January 29, 2021 Category: Biology Authors: Miller WP, Sunilkumar S, Dennis MD Tags: Free Radic Biol Med Source Type: research

LRRC8A contributes to angiotensin II-induced cardiac hypertrophy by interacting with NADPH oxidases via the C-terminal leucine-rich repeat domain.
Abstract Cardiac hypertrophy, an important cause of heart failure, is characterized by an increase in heart weight, the ventricular wall, and cardiomyocyte volume. The volume regulatory anion channel (VRAC) is an important regulator of cell volume. However, its role in cardiac hypertrophy remains unclear. The purpose of this study was to investigate the effect of leucine-rich repeat-containing 8A (LRRC8A), an essential component of the VRAC, on angiotensin II (AngII)-induced cardiac hypertrophy. Our results showed that LRRC8A expression, NADPH oxidase activity, and reactive oxygen species (ROS) production were inc...
Source: Free Radical Biology and Medicine - January 27, 2021 Category: Biology Authors: Huo C, Liu Y, Li X, Xu R, Jia X, Hou L, Wang X Tags: Free Radic Biol Med Source Type: research

NQO1 mediates the anti-inflammatory effects of nootkatone in lipopolysaccharide-induced neuroinflammation by modulating the AMPK signaling pathway.
Abstract Neuroinflammation and oxidative stress play key roles in the progression of neurodegenerative diseases. Thus, the use of potent anti-inflammatory/antioxidant agents has been suggested as a promising therapeutic strategy for neurodegenerative diseases. In the present study, we investigated the anti-inflammatory and antioxidant effects of nootkatone (NKT), a sesquiterpenoid compound isolated from grapefruit, in in vitro and in vivo models of neuroinflammation. In lipopolysaccharide (LPS)-stimulated BV2 microglial cells, NKT inhibited the expression of iNOS, COX-2, and pro-inflammatory cytokines, and increas...
Source: Free Radical Biology and Medicine - January 15, 2021 Category: Biology Authors: Park JE, Park JS, Leem YH, Kim DY, Kim HS Tags: Free Radic Biol Med Source Type: research

Co-delivery of EGFR and BRD4 siRNA by cell-penetrating peptides-modified redox-responsive complex in triple negative breast cancer cells
Publication date: Available online 10 December 2020Source: Life SciencesAuthor(s): Chi Zhang, Wen Yuan, Ying Wu, Xu Wan, Yanling Gong
Source: Life Sciences - December 13, 2020 Category: Biology Source Type: research

Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice
Publication date: Available online 9 December 2020Source: Life SciencesAuthor(s): Shima Bastaki, Surendar Aravindhan, Nasrin Ahmadpour Saheb, Mahsa Afsari Kashani, Aleksi Evgenievich Dorofeev, Fariba Karoon Kiani, Hediyeh Jahandideh, Farzaneh Beigi Dargani, Mohsen Aksoun, Afshin Nikkhoo, Ali Masjedi, Ata Mahmoodpoor, Majid Ahmadi, Sanam Dolati, Simin Namvar, Farhad Jadidi-Niaragh
Source: Life Sciences - December 10, 2020 Category: Biology Source Type: research

Transmembrane tumor necrosis factor alpha attenuates pressure-overload cardiac hypertrophy via tumor necrosis factor receptor 2
by Kun Miao, Ling Zhou, Hongping Ba, Chenxi Li, Haiyan Gu, Bingjiao Yin, Jing Wang, Xiang-ping Yang, Zhuoya Li, Dao Wen Wang Tumor necrosis factor-alpha (TNF-α) plays an important pathogenic role in cardiac hypertrophy and heart failure (HF); however, anti-TNF is paradoxically negative in clinical trials and even worsens HF, indicating a possible protective role of TNF-α in HF. TNF-α exists in transmembrane (tmTNF-α ) and soluble (sTNF-α) forms. Herein, we found that TNF receptor 1 (TNFR1) knockout (KO) or knockdown (KD) by short hairpin RNA or small interfering RNA (siRNA) significantly alleviated cardiac hypertroph...
Source: PLoS Biology: Archived Table of Contents - December 3, 2020 Category: Biology Authors: Kun Miao Source Type: research