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Total 656 results found since Jan 2013.
Astragaloside IV attenuates podocyte apoptosis through ameliorating mitochondrial dysfunction by up-regulated Nrf2-ARE/TFAM signaling in diabetic kidney disease
In this study, using molecular docking we found that Astragaloside IV (AS-IV), an active ingredient from traditional formula of Huangqi decoction (HQD), exerted a higher potential to promote Nrf2 escape from Keap1-Nrf2 interaction via competitively bind to amino acid sites in Keap1. When podocyte exposed to high glucose (HG) stimulation, mitochondrial morphological alterations and podocyte apoptosis were presented and accompanied by Nrf2 and mitochondrial transcription factor A (TFAM) downregulation. Mechanistically, HG promoted a decrease in mitochondria-specific electron transport chain (ETC) complexes, ATP synthesis and...
Source: Free Radical Biology and Medicine - April 8, 2023 Category: Biology Authors: Qian Shen Ji Fang Hengjiang Guo Xue Su Bingbing Zhu Xingmei Yao Yunman Wang Aili Cao Hao Wang Li Wang Source Type: research
STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice
In this study, we found that oleic acid/palmitic acid (OA/PA) increased the level of ferroptotic events including iron and ROS accumulation, upregulation of PTGS2 mRNA and protein levels, reduced SOD and GSH levels, and significant mitochondrial damage in H9C2 cells, which could be reversed by the ferroptosis inhibitor ferrostatin-1 (Fer-1). Intriguingly, we found that the autophagy inhibitor 3-methyladenine mitigated OA/PA-induced ferritin downregulation, iron overload and ferroptosis. OA/PA increased the protein level of NCOA4. Knockdown of NCOA4 by SiRNA partly reversed the reduction in ferritin, mitigated iron overload...
Source: Free Radical Biology and Medicine - March 20, 2023 Category: Biology Authors: Mengying Zhu Lulu Peng Shengqi Huo Dewei Peng Junyi Gou Wei Shi Jingwen Tao Tao Jiang Yue Jiang Qian Wang Bingyu Huang Lintong Men Sheng Li Jiagao Lv Li Lin Source Type: research
Nox4-and Tf/TfR-mediated peroxidation and iron overload exacerbate neuronal ferroptosis after intracerebral hemorrhage: Involvement of EAAT3 dysfunction
In this study, we investigated the molecular mechanisms by which neuronal ferroptosis occurs after ICH and whether the use of corresponding modulators can inhibit neuronal death and improve early outcomes in a rat ICH model. Our findings indicated that Nox4 and TF/TfR were upregulated in the perihematomal tissues of ICH rats. Oxidative stress and iron overload induced by Nox4 and TF/TfR promoted neuronal ferroptosis post-ICH. In contrast, application of Nox4-siRNA and the deferoxamine (DFO) attenuated peroxidation and iron deposition in the hemorrhagic brain, alleviated neuronal ferroptosis, and improved sensorimotor funct...
Source: Free Radical Biology and Medicine - February 22, 2023 Category: Biology Authors: Jiayu Xie Hongzhu Lv Xuanbei Liu Zhennan Xia Jiangwei Li Enhui Hong Boyun Ding Wenying Zhang Yizhao Chen Source Type: research
Identification of CCR2 as a hub in septic myocardial injury and cardioprotection of silibinin
In conclusion, this study systematically elucidated the key target of SIL in the treatment of septic myocardial injury. These findings provide valuable insights into the targets of sepsis and offer new avenues for exploring drug effect systematically.PMID:36693441 | DOI:10.1016/j.freeradbiomed.2023.01.020
Source: Free Radical Biology and Medicine - January 24, 2023 Category: Biology Authors: Chenxi Lu Wangrui Lei Meng Sun Xue Wu Qiong Liu Jie Liu Yaru Yang Wenwen Yang Zhe Zhang Xiaoru Li Yazhe Zhou Chao Deng Ying Chen Ye Tian Yang Yang Source Type: research
