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The involvement of hormone-sensitive lipase in all-trans retinoic acid induced cleft palate
Int J Dev Biol. 2023 Jan 20. doi: 10.1387/ijdb.220137kz. Online ahead of print.ABSTRACTAbnormally high concentrations of all-trans retinoic acid (atRA) induce cleft palate, which is accompanied by abnormal migration and proliferation of mouse embryonic palatal mesenchyme (MEPM) cells. Hormone-sensitive lipase (HSL) is involved in many embryonic development processes. The current study was designed to elucidate the mechanism of HSL in cleft palate induced by atRA. To establish a cleft palate model in Kunming mice, pregnant mice were administered atRA (70 mg/kg) by gavage at embryonic Day 10.5 (E10.5). Embryonic palates were...
Source: International Journal of Developmental Biology - January 23, 2023 Category: Biology Authors: K Zheng Q N Ye Source Type: research
