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Total 656 results found since Jan 2013.
Hypothermia Promotes Mitochondrial Elongation In Cardiac Cells Via Inhibition Of Drp1
In conclusion hypothermia promoted elongation of cardiac mitochondria via reduced pDrp1S616 abundance which was also associated with suppression of cellular oxygen consumption. Silencing of TRPV1 in H9c2 cardiomyocytes reproduced the morphological and respirometric phenotype of hypothermia. This report demonstrates a novel mechanism of cold-induced inhibition of mitochondrial fission.PMID:34331901 | DOI:10.1016/j.cryobiol.2021.07.013
Source: Cryobiology - July 31, 2021 Category: Biology Authors: David Taylor Juliana Germano Yang Song Hanane Hadj-Moussa Stefanie Marek-Iannucci Raeesa Dhanji Jon Sin Lawrence S C Czer Kenneth B Storey Roberta A Gottlieb Source Type: research
Activation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) with Lidocaine Provokes Pyroptosis of Glioblastoma Cells
The study examines the problem whether pyroptosis of U87-MG glioblastoma cells can result from activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) by a local anesthetic. Glioblastoma cells exposed to various concentrations of typical local anesthetic lidocaine demonstrated augmented cytosolic flux of Ca2+, while suppression of CaMKII expression with the corresponding siRNA significantly inhibited this effect in cells treated with 2 mM lidocaine. Lidocaine up-regulated the expression of mRNA caspase-3 and gasdermin GSDME proteins, whereas silencing of CaMKII gene with siRNA significantly moderated this effect...
Source: Bulletin of Experimental Biology and Medicine - July 24, 2021 Category: Biology Source Type: research
MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease
This study investigated MAPK15-ULK1 signaling in airway epithelial cells of COPD patients and its activation by cigarette smoke extract (CSE) in isolated human airway epithelial cells. Significant increased phosphorylation of MAPK15 and ULK1 (Ser555) was detected in the airway epithelium of COPD patients. This pathology was maintained in isolated primary COPD-epithelial cells. Compared to control cells, the protein expression of Beclin1 and the ratio of LC3II to LC3I were both significantly increased in COPD-epithelial cells. In human airway epithelial cells, CSE significantly increased the phosphorylation of MAPK15, ULK1 ...
Source: Free Radical Biology and Medicine - July 5, 2021 Category: Biology Authors: Ming Zhang Lei Fang Liang Zhou Antonio Molino Maria Rosaria Valentino Shuanying Yang Jie Zhang Yali Li Michael Roth Source Type: research
Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease
Free Radic Biol Med. 2021 Jun 23:S0891-5849(21)00385-3. doi: 10.1016/j.freeradbiomed.2021.06.020. Online ahead of print.ABSTRACTVascular calcification is very commonly observed in patients with chronic kidney disease (CKD), but there is no efficient therapy available. Oxidative stress plays critical roles in the progression of vascular calcification. Celastrol (Cel), a natural constituent derived from Chinese herbals, exhibits anti-oxidative stress activity. Here, we investigated the effect of celastrol on vascular calcification using vascular smooth muscle cells (VSMCs), arterial rings and CKD rats. Alizarin red staining ...
Source: Free Radical Biology and Medicine - June 26, 2021 Category: Biology Authors: Xiulin Yang An Chen Qingchun Liang Qianqian Dong Mingwei Fu Xiaoyu Liu Siyi Wang Yining Li Yuanzhi Ye Zirong Lan Jing-Song Ou Lihe Lu Jianyun Yan Source Type: research
City of Hope and Griffith University develop direct-acting antiviral to treat COVID-19
(City of Hope) An international team of scientists have developed an experimental direct-acting antiviral therapy to treat COVID-19. Traditional antivirals reduce symptoms and help people recover earlier. This next-generation antiviral approach used gene-silencing RNA technology called siRNA (small-interfering RNA) to attack the virus' genome directly, which stops the virus from replicating, as well as lipid nanoparticles designed at Griffith University and City of Hope to deliver the siRNA to the lungs, the critical site of infection.
Source: EurekAlert! - Biology - May 18, 2021 Category: Biology Source Type: news
hTERT-molecular targeted therapy of ovarian cancer cells via folate-functionalized PLGA nanoparticles co-loaded with MNPs/siRNA/wortmannin
Publication date: 15 July 2021Source: Life Sciences, Volume 277Author(s): Somayyeh Ghareghomi, Shahin Ahmadian, Nosratollah Zarghami, Salar Hemmati
Source: Life Sciences - May 17, 2021 Category: Biology Source Type: research
Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3 β signaling pathway
In conclusion, our results suggested that administration of KP54 attenuated oxidative stress, neuronal apoptosis and neurobehavioral impairments through GPR54/ARRB2/AKT/GSK3β signaling pathway after SAH in rat. Thus, KP54 may provide an effective treatment strategy for SAH patients.PMID:33989759 | DOI:10.1016/j.freeradbiomed.2021.05.012
Source: Free Radical Biology and Medicine - May 14, 2021 Category: Biology Authors: Yi Huang Yong Guo Lei Huang Yuanjian Fang Dujuan Li Rui Liu Qin Lu Reng Ren Lihui Tang Lifei Lian Yongmei Hu Jiping Tang Gao Chen John H Zhang Source Type: research
Molecular characterization of ubiquitin-conjugating enzyme gene ube2h and siRNA-mediated regulation on targeting p53 in turbot, Scophthalmus maximus
Publication date: Available online 5 May 2021Source: Journal of Thermal BiologyAuthor(s): Xiaoli Guo, Aijun Ma, Zhihui Huang, Xin-an Wang, Kai Yang, Zhifeng Liu, Jinsheng Zhang, Wenxiao Cui
Source: Journal of Thermal Biology - May 6, 2021 Category: Biology Source Type: research
Sodium fluoride activates the extrinsic apoptosis via regulating NOX4/ROS-mediated p53/DR5 signaling pathway in lung cells both in vitro and in vivo
In this study, we report that death receptor 5 (DR5), a major component of the extrinsic apoptotic pathway, is markedly induced upon NaF stimulation. Enhanced DR5 induction was necessary for the apoptotic effects of NaF, inasmuch as transfected BEAS-2B cells with DR5 siRNA attenuated NaF-induced caspase-8 activation in lung cells. Mechanism investigation indicated that the induction of DR5, following NaF exposure, was mediated by tumor protein 53 (p53)-dependent transcriptional activation. Notably, we demonstrated that NaF could induce a significant increase in intracellular reactive oxygen species (ROS) level derived from...
Source: Free Radical Biology and Medicine - April 15, 2021 Category: Biology Authors: Chao Song Dongmei Shi Kaiwen Chang Xianghui Li Qing Dong Xia Ma Xuefei Wang Zhenhuan Guo Yonglu Liu Jundong Wang Source Type: research
