Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3 β signaling pathway

In conclusion, our results suggested that administration of KP54 attenuated oxidative stress, neuronal apoptosis and neurobehavioral impairments through GPR54/ARRB2/AKT/GSK3β signaling pathway after SAH in rat. Thus, KP54 may provide an effective treatment strategy for SAH patients.PMID:33989759 | DOI:10.1016/j.freeradbiomed.2021.05.012

Source: Free Radical Biology and Medicine - May 14, 2021 Category: Biology Authors: Yi Huang Yong Guo Lei Huang Yuanjian Fang Dujuan Li Rui Liu Qin Lu Reng Ren Lihui Tang Lifei Lian Yongmei Hu Jiping Tang Gao Chen John H Zhang Source Type: research