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Total 656 results found since Jan 2013.
Dimethyl fumarate attenuates lipopolysaccharide-induced mitochondrial injury by activating Nrf2 pathway in cardiomyocytes
Publication date: Available online 9 September 2019Source: Life SciencesAuthor(s): Chun-Yan Fu, Jun Chen, Xiao-Yang Lu, Ming-Zhi Zheng, Lin-Lin Wang, Yue-Liang Shen, Ying-Ying ChenAbstractAimsTo determine whether dimethyl fumarate (DMF) can protect against lipopolysaccharide (LPS) -induced myocardial injury.Main methodsH9c2 cells pretreated with or without DMF were stimulated with LPS. Cell viability and apoptosis were evaluated. Nrf2 and HO-1 expression were detected using Western blotting. Mitochondrial morphology, mitochondrial and superoxide production were observed using confocal microscope. Mitochondrial respiration ...
Source: Life Sciences - September 10, 2019 Category: Biology Source Type: research
L-carnitine regulated Nrf2/Keap1 activation in vitro and in vivo and protected oxidized fish oil-induced inflammation response by inhibiting the NF-κB signaling pathway in Rhynchocypris lagowski Dybowski
In conclusion, l-carnitine regulated Nrf2/Keap1 activation in vitro and in vivo and protected oxidized fish oil-induced inflammation response by inhibiting the NF-κB signaling pathway in Rhynchocypris lagowski Dybowski.
Source: Fish and Shellfish Immunology - September 6, 2019 Category: Biology Source Type: research
Circular RNA 4099 aggravates hydrogen peroxide-induced injury by down-regulating microRNA-706 in L02 cells
This study aimed to explore the roles and regulatory mechanisms of the circRNA-4099 in L02 cell line.Main methodsCells were induced with H2O2 dilutions and transfected with circRNA-4099 overproduction vectoer and the specific siRNA (si-circRNA-4099), as well as microRNA-706 (miR-706) mimic or the corresponding controls. Cell viability was detected with the CCK-8. The apoptotic rate was determined by the annexin v-FITC/PI with flow cytometer. The expression of circRNA-4099 or miR-706 was quantified depending on qRT-PCR. The reactive oxygen species (ROS) level was examined through ROS assay. The relative proteins were indivi...
Source: Life Sciences - September 1, 2019 Category: Biology Source Type: research
Effects of MFHAS1 on cognitive impairment and dendritic pathology in the hippocampus of septic rats
Publication date: Available online 30 August 2019Source: Life SciencesAuthor(s): Jing Zhong, Chenyue Guo, Wenting Hou, Na Shen, Changhong MiaoAbstractAimsTo investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associated encephalopathy (SAE) rats.Main methodsThe rats were randomly divided into four groups: 1) control group (subjected to sham surgery), 2) control plus Mfhas...
Source: Life Sciences - September 1, 2019 Category: Biology Source Type: research
Downregulation of hsa_circ_0007534 restricts the proliferation and invasion of cervical cancer through regulating miR-498/BMI-1 signaling
Publication date: Available online 21 August 2019Source: Life SciencesAuthor(s): Xuan Rong, Wei Gao, Xiaomei Yang, Junjun GuoAbstractAimsHsa_circ_0007534 has been reported to be a novel cancer-related circRNA affecting multiple cancers. However, little is known about the role of hsa_circ_0007534 in cervical cancer specifically. In the current study, we aimed to explore the expression and function of hsa_circ_0007534 in cervical cancer.Main methodsThe expression of circRNA, miRNA and mRNA was measured using real-time quantitative polymerase chain reactions. Protein expression was assessed by Western blot. Knockdown of has_c...
Source: Life Sciences - August 22, 2019 Category: Biology Source Type: research
Inhibition of Mycobacterium tuberculosis tRNA-Ligases Using siRNA-Based Gene Silencing Method: A Computational Approach
Journal of Computational Biology, Ahead of Print.
Source: Journal of Computational Biology - August 21, 2019 Category: Biology Authors: Partha Sarathi Mohanty Sandeep Sharma Farah Naaz Dilip Kumar Archana Raikwar Shripad A. Patil Source Type: research
Functional characterization of seven-band grouper immunoglobulin like cell adhesion molecule, Nectin4 as a cellular receptor for nervous necrosis virus
Publication date: October 2019Source: Fish & Shellfish Immunology, Volume 93Author(s): Rahul Krishnan, Syed Shariq Nazir Qadiri, Myung-Joo OhAbstractNectin-4/PVRL4 belonging to the family of immunoglobulin-like cell adhesion molecules was identified as a potential cellular receptor for several animal viruses. Here we show that nervous necrosis virus that causes viral nervous necrosis in teleosts uses the same receptor in its life cycle. Transfection of SSN-1 cell lines with an expression vector encoding Nectin-4 rendered them to be more susceptible to NNV. Immunofluorescence microscopy on Nectin-4 expressing cells reveal...
Source: Fish and Shellfish Immunology - August 20, 2019 Category: Biology Source Type: research
Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway
Publication date: Available online 15 August 2019Source: Life SciencesAuthor(s): Xuelian Li, Zhiyang Li, Bingong Li, Xianjie Zhu, Xingjun LaiAbstractAimsNLRP3 inflammasome activation is essential for the development and prognosis of diabetic cardiomyopathy (DCM). The anti-aging protein Klotho is suggested to modulate tissue inflammatory responses. The aim of the present study was to examine the protective effects of Klotho on DCM.Main methodsA streptozotocin-induced diabetes mouse model was established to assess the effects of Klotho in vivo, which was administered for 12 weeks. The characteristics of type 1 DCM were eva...
Source: Life Sciences - August 18, 2019 Category: Biology Source Type: research
Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins
Publication date: Available online 5 August 2019Source: Life SciencesAuthor(s): Hu Li, Rahmani Mohammad Malyar, Nianhui Zhai, Hong Wang, Kai Liu, Dandan Liu, Cuiling Pan, Fang Gan, Kehe Huang, Jinfeng Miao, Xingxiang ChenAbstractAimsThe present study was to investigate the protective effects of Zn supplementation in OTA-induced apoptosis of Madin-Darby canine kidney (MDCK) epithelial cells and explore the potential mechanisms. Aiming to provides a new insight into the treatment strategy of OTA-induced nephrotoxicity by nutritional regulation.Main methodsInitially, through MTT and LDH assay revealed that Zn supplementation ...
Source: Life Sciences - August 18, 2019 Category: Biology Source Type: research
LncRNA AK094457 promotes AngII-mediated hypertension and endothelial dysfunction through suppressing of activation of PPARγ
In conclusion, lncRNA AK094457 is identified as a key regulator in blood pressure and endothelial function, which can increase AngII-induced hypertension and endothelial dysfunction via suppression of PPARγ.
Source: Life Sciences - August 14, 2019 Category: Biology Source Type: research
miRNA-21 Inhibition suppresses the human epithelial ovarian cancer by targeting PTEN signal pathway
ConclusionThe suppression of microRNA-21 inhibits the progression of EOC profoundly. In EOC, miR-21 is negatively correlated with the expression of PTEN gene.
Source: Saudi Journal of Biological Sciences - August 10, 2019 Category: Biology Source Type: research
Free heme regulates placenta growth factor through NRF2-antioxidant response signaling.
Abstract
Free heme activates erythroblasts to express and secrete Placenta Growth Factor (PlGF), an angiogenic peptide of the VEGF family. High circulating levels of PlGF have been associated in experimental animals and in patients with sickle cell disease with echocardiographic markers of pulmonary hypertension, a life-limiting complication associated with more intense hemolysis. We now show that the mechanism of heme regulation of PlGF requires the contribution of the key antioxidant response regulator NRF2. Mimicking the effect of heme, the NRF2 agonist sulforaphane stimulates the PlGF transcript level nearly 3...
Source: Free Radical Biology and Medicine - August 9, 2019 Category: Biology Authors: Kapetanaki MG, Gbotosho OT, Sharma D, Weidert F, Ofori-Acquah SF, Kato GJ Tags: Free Radic Biol Med Source Type: research
Oxidized base 8-oxoguanine, a product of DNA repair processes, contributes to dendritic cell activation.
Abstract
A growing body of evidence suggests that elevated levels of reactive oxygen species (ROS) in the airways caused by exposure to gas phase pollutants or particulate matter are able to activate dendritic cells (DCs); however, the exact mechanisms are still unclear. When present in excess, ROS can modify macromolecules including DNA. One of the most abundant DNA base lesions is 7,8-dihydro-8-oxoguanine (8-oxoG), which is repaired by the 8-oxoguanine DNA glycosylase 1 (OGG1)-initiated base excision repair (BER) pathway. Studies have also demonstrated that in addition to its role in repairing oxidized purines, ...
Source: Free Radical Biology and Medicine - August 9, 2019 Category: Biology Authors: Pázmándi K, Sütő M, Fekete T, Varga A, Boldizsár E, Boldogh I, Bácsi A Tags: Free Radic Biol Med Source Type: research
The first cloned echinoderm tumor necrosis factor receptor from Holothuria leucospilota: Molecular characterization and functional analysis
This study provides evidences for the potential roles of sea cucumber TNFR in the innate immunity.
Source: Fish and Shellfish Immunology - August 8, 2019 Category: Biology Source Type: research
Molecular cloning of Y-Box binding protein-1 from mandarin fish and its roles in stress-response and antiviral immunity
Publication date: October 2019Source: Fish & Shellfish Immunology, Volume 93Author(s): Jian He, Tao-Lin Xie, Xiao Li, Yang Yu, Zhi-Peng Zhan, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo HeAbstractMandarin fish (Siniperca chuatsi) is a universally farmed fish species in China and has a large farming scale and economic value. With the high-density cultural mode in mandarin fish, viral diseases, such as infectious spleen and kidney necrosis virus (ISKNV) and Siniperca chuatsi rhabdovirus (SCRV), have increased loss, which has seriously restricted the development of aquaculture. Y-Box binding protein 1 (YB-1) is a member of cold s...
Source: Fish and Shellfish Immunology - August 3, 2019 Category: Biology Source Type: research
