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Total 656 results found since Jan 2013.
Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease
In conclusion, our findings confirmed that CAV1 exerts a protective effect against vascular injury by inhibiting oxidative stress and inflammation through the PKC/MAPK pathway. Therefore, restoration of CAV1 may have clinical benefits in reducing APAP-induced vascular damage in NAFLD patients.PMID:36596386 | DOI:10.1016/j.freeradbiomed.2022.12.095
Source: Free Radical Biology and Medicine - January 3, 2023 Category: Biology Authors: Dongdong Fu Shuai Wu Xiangfu Jiang Tingyu You Yu Li Jiao Xin Xiaowen Feng Jiagen Wen Yan Huang Chengmu Hu Source Type: research
A fast lasso-based method for inferring higher-order interactions
by Kieran Elmes, Astra Heywood, Zhiyi Huang, Alex Gavryushkin
Large-scale genotype-phenotype screens provide a wealth of data for identifying molecular alterations associated with a phenotype. Epistatic effects play an important role in such association studies. For example, siRNA perturbation screens can be used to identify combinatorial gene-silencing effects. In bacteria, epistasis has practical consequences in determining antimicrobial resistance as the genetic background of a strain plays an important role in determining resistance. Recently developed tools scale to human exome-wide screens for pairwise interactions,...
Source: PLoS Computational Biology - December 29, 2022 Category: Biology Authors: Kieran Elmes Source Type: research
Alternative splicing of a carboxyl/choline esterase gene enhances the fenpropathrin tolerance of Tetranychus cinnabarinus
This article is protected by copyright. All rights reserved
Source: Insect Science - December 22, 2022 Category: Biology Authors: Peng Wei,
Xinying Zeng,
Haonan Han,
Yiqing Yang,
Youjun Zhang,
Lin He Tags: ORIGINAL ARTICLE Source Type: research
SIRT3 Promotes the Development of Esophageal Squamous Cell Carcinoma by Regulating Hexokinase 2 through the AKT Signaling Pathway
In the present study, we explored whether sirtuin-3 (SIRT3) regulates the proliferation and migration of esophageal squamous cell carcinoma (ESCC) and investigated the mechanisms underlying the oncogene role of SIRT3. siRNA was used to transfect Eca109 cells and downregulate SIRT3. The proliferation and migration of Eca109 cells were examined by the CCK-8 assay, colony formation assay, Transwell assay, and scratch test. Quantitative real-time PCR and Western blotting were used to detect SIRT3, hexokinase 2, AKT, and p-AKT in Eca109 cells. Functional assays showed that downregulation of SIRT3 could inhibit the proliferation...
Source: Bulletin of Experimental Biology and Medicine - November 28, 2022 Category: Biology Source Type: research
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling
In conclusion, SIRT7 alleviates renal ferroptosis, lipid peroxidation, and partial EMT under hypertensive status by facilitating the KLF15/Nrf2 signaling, thereby mitigating renal fibrosis, injury and dysfunction. Targeting SIRT7 signaling serves as a promising strategy for hypertension and hypertensive renal injury.PMID:36334846 | DOI:10.1016/j.freeradbiomed.2022.10.320
Source: Free Radical Biology and Medicine - November 5, 2022 Category: Biology Authors: Xue-Ting Li Jia-Wei Song Zhen-Zhou Zhang Mi-Wen Zhang Li-Rong Liang Ran Miao Ying Liu Yi-Hang Chen Xiao-Yan Liu Jiu-Chang Zhong Source Type: research
The clock gene, period, influences migratory flight and reproduction of the oriental armyworm, Mythimna separata
This article is protected by copyright. All rights reserved
Source: Insect Science - October 29, 2022 Category: Biology Authors: Jiayue Ji,
Yueqiu Liu,
Lei Zhang,
Yunxia Cheng,
David Stanley,
Xingfu Jiang Tags: ORIGINAL ARTICLE Source Type: research
Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF- α by reduction of fatty acid β-oxidation and anti-oxidation
Free Radic Biol Med. 2022 Sep 9:S0891-5849(22)00583-4. doi: 10.1016/j.freeradbiomed.2022.09.002. Online ahead of print.ABSTRACTTumor necrosis factor-α (TNF-α) is an inflammatory cytokine involved in cell survival, apoptosis, and homeostasis. However, the regulatory effect of TNF-α on mesenchymal stem cell (MSC) redox regulation remains unknown. The process of delaying the senescence of MSCs and maintaining antioxidation mechanism is important in transplantation therapy to treat inflammatory diseases that result from restricted immunomodulatory effects of senescent MSCs. Thus, we examined the role of TNF-α-mediated sign...
Source: Free Radical Biology and Medicine - September 12, 2022 Category: Biology Authors: Young Hyun Jung Chang Woo Chae Han Seung Chang Gee Euhn Choi Hyun Jik Lee Ho Jae Han Source Type: research
BioClay < sup > TM < /sup > prolongs RNA interference-mediated crop protection against Botrytis cinerea
This article is protected by copyright. All rights reserved.PMID:36040241 | DOI:10.1111/jipb.13353
Source: Journal of Integrative Plant Biology - August 30, 2022 Category: Biology Authors: Jonatan Ni ño-Sánchez Prabhakaran Thanjavur Sambasivam Anne Sawyer Rachael Hamby Angela Chen Elizabeth Czislowski Peng Li Narelle Manzie Donald M Gardiner Rebecca Ford Zhi Ping Xu Neena Mitter Hailing Jin Source Type: research
A novel BMP2 secretagogue ameliorates glucocorticoid induced oxidative stress in osteoblasts by activating NRF2 dependent survival while promoting Wnt/ β-catenin mediated osteogenesis
Free Radic Biol Med. 2022 Aug 10:S0891-5849(22)00514-7. doi: 10.1016/j.freeradbiomed.2022.08.007. Online ahead of print.ABSTRACTIn our previous study, a novel BMP2 secretagogue was synthesized belonging to a class of galloyl conjugates of flavanones, with remarkable osteogenic potential that promoted bone regeneration. We aimed to establish the protective effect of our compound against bone loss that co-exists with excess Glucocorticoid (GC) therapy. GC therapy induces osteoblast damage leading to apoptosis by increasing reactive oxygen species (ROS). Our results delineate that compound 5e (a BMP2 secretagogue) activates N...
Source: Free Radical Biology and Medicine - August 13, 2022 Category: Biology Authors: Divya Rai Ashish Kumar Tripathi Anirban Sardar Alka Raj Pandey Shradha Sinha Kunal Chutani Geeta Dhaniya Priyanka Kothari Koneni V Sashidhara Ritu Trivedi Source Type: research
