Role of PGRMC1 in cell physiology of cervical cancer

In this study, we performed 2D-DIGE and MALDI-TOF/TOF MS to analyze differentially expressed proteins between HeLa and invasive HeLa-I5 cells..Key findingsAccording to our proteomics data, 68 differentially expressed proteins between the HeLa and HeLa-I5 cells were identified. One of these differentially expressed proteins, Progesterone receptor membrane component 1 (PGRMC1), was selected as a candidate for further studies. To correlate the role of PGRMC1 with cellular migration and cancer progression, small interfering RNA (siRNA) was used to knockdown the expression of PGRMC1. Similar function of PGRMC1 was also observed in two other cervical cancer lines, CaSki and ME-180.SignificancePGRMC1 plays an essential role in regulating cancer progression and metastasis of cervical cancer cells, thus serving as a potential therapeutic target for cervical cancer.
Source: Life Sciences - Category: Biology Source Type: research

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CONCLUSION: There is a lack of knowledge and misinformation regarding cervical cancer, Pap smears, HPV, and HPV association with cervical cancer. These data can be used as a basis to formulate effective population awareness programs. PMID: 31219489 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Publication date: Available online 10 May 2019Source: Social Science &MedicineAuthor(s): Beth Sundstrom, Ellie Smith, Cara Delay, John Luque, Caroline Davila, Bailey Feder, Vincenza Paddock, Jessie Poudrier, Jennifer Young Pierce, Heather M. BrandtAbstractCervical cancer is a preventable disease. HPV infection has been linked to more than 90% of cervical cancers. A vaccine to prevent the acquisition of HPV has been available since 2006. The purpose of this study was to investigate women's perceptions of cervical cancer prevention, including HPV vaccination. A reproductive justice framework guided data collection and an...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Trials suggest simple home test could replace discomfort or embarrassment of smears Related items fromOnMedica Four in five girls have had HPV jab One or two doses of HPV jab may be enough Nurse guidance published on cervical cancer and HPV Parents unsure of HPV vaccine for daughters Preventing cervical cancer: how a screening switch and HPV vaccination should cut cancer rates
Source: OnMedica Latest News - Category: UK Health Source Type: news
We report a case of misdiagnosed endometrial cancer by D&C, but with a positive cytopathological finding. Following that, a meta-analysis including 4,179 patients of endometrial diseases with cyto-histopathological results was performed to assess the value of the endometrial cytological method in endometrial cancer diagnosis. The pooled sensitivity and specificity of the cytological method in detecting endometrial atypical hyperplasia or cancer was 0.91[95% confidence interval (CI) 0.74–0.97] and 0.96 (95% CI 0.90–0.99), respectively. The pooled positive likelihood ratio and negative likelihood ratio was 25.4 (...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
(see:Startup uses phone, light and AI to detect cervical cancer)Israeli startup MobileODT has created the Eva System, which uses an Automated Visual Evaluation (AVE) algorithm that it says can detect cervical cancer by simply examining an image of the cervix (Courtesy) Israeli startup MobileODT has created the Eva System, which uses an Automated Visual Evaluation (AVE) algorithm that it says can detect cervical cancer by simply examining an image of the cervix (Courtesy) Israeli start-up MobileODT says it can detect cervical cancer more accurately and inexpensively than the standard colposcopy method used today, by creatin...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Source Type: blogs
Abstract George Papanicolaou, a Greek immigrant and cytopathologist, was responsible for what is now colloquially known as the "Pap smear"-undoubtedly one of the greatest advances in medicine and public health of the last century. However, his landmark research on the development of cervical cytology for the detection of precancerous lesions of the cervix ("New Cancer Diagnosis," 1928) made a rather inauspicious debut in an unlikely venue: John Harvey Kellogg's Third Race Betterment Conference-a meeting devoted to the furtherance of the concept and implementation of eugenics. Herein, we discuss...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
Surge in number of smear tests come as laboratories prepare for shake-up Related items fromOnMedica Preventing cervical cancer: how a screening switch and HPV vaccination should cut cancer rates Social media could help raise breast screening take-up Armed forces wives at greater risk of perinatal depression Cervical screening intervals should be extended Breast cancer age profile younger in non-white women
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractCervical cancer continues to be a global health problem; despite the potential for prevention through organised screening programmes that can detect and treat pre-cancerous lesions and also more recently, the availability of HPV (Human Papilloma Virus) vaccines. While routine screening with Pap smear testing has reduced the burden of cervical cancer in the high-income countries, the implementation of organised Pap-based screening programmes has not been found feasible in low-resource settings due to a lack of health care delivery infrastructure and limited health budgets. The well-established causal relationship be...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
PHE drops ‘smear’ word as one in four eligible women in England misses screening – a 20-year low Related items fromOnMedica Some doctors misunderstand smear test says GP JCVI recommends universal HPV vaccination Parents unsure of HPV vaccine for daughters Experts call for wider HPV vaccination Cancer strategies failed to improve one-year survival
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractImplementing a HPV vaccination program is currently under evaluation by the Turkish health ministry. For screening and vaccination programs to be successful, the cooperation of nurses is essential. We aimed to evaluate (1) basic knowledge of nurses and nursing interns regarding HPV infection and cervical cancer, (2) their attitudes towards smear testing and HPV vaccination, and (3) their viewpoint on vaccination of school age children. This cross-sectional study was undertaken at Bezmialem Vakif University. The survey was designed to assess knowledge about HPV infection, Pap smear testing, cervical cancer, HPV vacc...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
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