Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1 α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE.

In conclusion, our data demonstrated that ghrelin reduced oxidative stress injury and neuronal apoptosis which was in part via the GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 signalling pathway after HI. Ghrelin may be a novel therapeutic target for treatment after neonatasl HI injury.
PMID: 31279091 [PubMed - as supplied by publisher]

Source: Free Radical Biology and Medicine - July 2, 2019 Category: Biology Authors: Huang J, Liu W, Doycheva DM, Gamdzyk M, Lu W, Tang J, Zhang JH Tags: Free Radic Biol Med Source Type: research