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Total 656 results found since Jan 2013.

ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts
This study reveals a novel role for ERK5−MEF2 cascade, linking bFGF-induced PAI-1 expression and subsequent mitogenic processes in lung fibroblasts.
Source: Life Sciences - May 31, 2015 Category: Biology Source Type: research

The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells Research Communication
We have previously identified a zinc finger transcription factor, ZNF24 (zinc finger protein 24), as a novel inhibitor of tumor angiogenesis and have demonstrated that ZNF24 exerts this effect by repressing the transcription of VEGF in breast cancer cells. Here we focused on the role of ZNF24 in modulating the angiogenic potential of the endothelial compartment. Knockdown of ZNF24 by siRNA in human primary microvascular endothelial cells (ECs) led to significantly decreased cell migration and invasion compared with control siRNA. ZNF24 knockdown consistently led to significantly impaired VEGF receptor 2 (VEGFR2) signaling ...
Source: FASEB Journal - April 1, 2015 Category: Biology Authors: Jia, D., Huang, L., Bischoff, J., Moses, M. A. Tags: Research Communication Source Type: research

Transposable elements, mRNA expression level and strand-specificity of small RNAs are associated with non-additive inheritance of gene expression in hybrid plants
Conclusions: The data presented here is consistent with a role for differential mRNA decay kinetics as one mechanism contributing to high-parent dominance in gene expression. Our evidence is also consistent with trans repression by siRNA and TEs as the cause of low-parent dominance.
Source: BMC Plant Biology - July 3, 2015 Category: Biology Authors: Qing LiYing LiStephen MooseMatthew Hudson Source Type: research

Tetramethylpyrazine prevents ethanol-induced hepatocyte injury via activation of nuclear factor erythroid 2-related factor 2
Publication date: 15 November 2015 Source:Life Sciences, Volume 141 Author(s): Chunfeng Lu, Yuanyuan Jiang, Feng Zhang, Jiangjuan Shao, Li Wu, Xiafei Wu, Naqi Lian, Lianyun Chen, Huanhuan Jin, Qin Chen, Yin Lu, Shizhong Zheng Aims Inhibiting the major features of alcoholic liver disease (ALD) such as lipid accumulation and oxidative stress is a promising strategy of treating ALD. Tetramethylpyrazine (TMP) has curative effects on various diseases. However, the effects of TMP on ethanol-induced hepatocyte injury and the related mechanisms remain unclear. The aim of this study is to elucidate the effects of TMP ...
Source: Life Sciences - October 4, 2015 Category: Biology Source Type: research

Analysis of the Role of Insulin Signaling in Bone Turnover Induced by Fluoride.
In conclusion, insulin played the important role in bone lesion induced by excessive amount of fluoride through mediating InR receptor signaling, and IGF1 signaling probably exerted action on bone turnover caused by overdose of fluoride. PMID: 26521058 [PubMed - as supplied by publisher]
Source: Biological Trace Element Research - October 31, 2015 Category: Biology Authors: Liu Q, Liu H, Yu X, Wang Y, Yang C, Xu H Tags: Biol Trace Elem Res Source Type: research

DHA-induced stress response in human colon cancer cells-focus on oxidative stress and autophagy.
Abstract Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n-3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have been well documented in relation to several diseases. Increasing evidence suggests that n-3 PUFAs may have anticancer activity and improve the effect of conventional cancer therapy. The mechanisms behind these effects are still unclear and need to be elucidated. We have examined the DHA-induced stress response in two human colon cancer cell lines, SW620 and Caco-2. SW620 cells are growth-inhibited a...
Source: Free Radical Biology and Medicine - November 13, 2015 Category: Biology Authors: Pettersen K, Monsen VT, Hakvåg Pettersen CH, Overland HB, Pettersen G, Samdal H, Tesfahun AN, Lundemo AG, Bjørkøy G, Schønberg S Tags: Free Radic Biol Med Source Type: research

Citron Rho-interacting kinase mediates arsenite-induced decrease in endothelial nitric oxide synthase activity by increasing phosphorylation at threonine 497: Mechanism underlying arsenite-induced vascular dysfunction.
In conclusion, we demonstrate that arsenite acutely inhibits eNOS enzymatic activity and vessel relaxation in part by increasing the RhoA/CRIK/eNOS-Thr(497) phosphorylation signaling axis, which provides a molecular mechanism underlying arsenite-induced impaired vascular diseases. PMID: 26593676 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - November 16, 2015 Category: Biology Authors: Seo J, Cho DH, Lee HJ, Sung MS, Young Lee J, Won KJ, Park JH, Jo I Tags: Free Radic Biol Med Source Type: research

Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-{beta} Research Communication
Chronic fibroproliferative diseases account for approximately 45% of all deaths in the developed world. In the kidney, glomerulosclerosis is the underlying pathology in approximately half of patients with renal failure receiving dialysis. Mesangial cell expression of the LIM protein hydrogen peroxide-induced clone-5 (Hic-5) is important in its pathogenesis. Hic-5 expression increases following mesangial cell attachment to collagen I, associated with increased collagen I expression and increased susceptibility to apoptosis both in vitro and in experimental glomerulosclerosis. TGF-β has an established role in many fibro...
Source: FASEB Journal - December 1, 2015 Category: Biology Authors: Hornigold, N., Mooney, A. Tags: Research Communication Source Type: research

Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid
In this study, the expression of a common neuronal differentiation marker [neurofilament M (NF-M)] in human SK-N-SH neuroblastoma cells treated with 10μM all-trans retinoic acid (ATRA) showed significantly increased expression in accordance with reduced cell number. This was accompanied by an increase in MitoSOX and DCFH2 oxidation that could be indicative of increased steady-state levels of reactive oxygen species (ROS) such as O2 •− and H2O2, which correlated with increased levels of MnSOD activity and immuno-reactive protein. Furthermore PEG-catalase inhibited the DCFH2 oxidation signal to a greater extent in the A...
Source: Redox Biology - December 8, 2015 Category: Biology Source Type: research

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage Research Communication
Itaconate is a nonamino organic acid exhibiting antimicrobial effects. It has been recently identified in cells of macrophage lineage as a product of an enzyme encoded by immunoresponsive gene 1 (Irg1), acting on the citric acid cycle intermediate cis-aconitate. In mitochondria, itaconate can be converted by succinate–coenzyme A (CoA) ligase to itaconyl-CoA at the expense of ATP (or GTP), and is also a weak competitive inhibitor of complex II. Here, we investigated specific bioenergetic effects of increased itaconate production mediated by LPS-induced stimulation of Irg1 in murine bone marrow–derived macrophage...
Source: FASEB Journal - January 5, 2016 Category: Biology Authors: Nemeth, B., Doczi, J., Csete, D., Kacso, G., Ravasz, D., Adams, D., Kiss, G., Nagy, A. M., Horvath, G., Tretter, L., Mocsai, A., Csepanyi-Kömi, R., Iordanov, I., Adam-Vizi, V., Chinopoulos, C. Tags: Research Communication Source Type: research

Resveratrol induces intracellular Ca2+ rise via T-type Ca2+ channels in a mesothelioma cell line
This study was designed to determine whether Res affects Ca2+ signaling in cancer cells. Main methods We used the REN human mesothelioma cell line, as an in vitro cancer cell model, and the non-malignant human mesothelial MeT5A cell line, as normal cell model. Cytosolic Ca2+ concentration was measured by the fluorescent indicator Fura-2. Immunofluorescence, Western blot, and siRNA technique were employed to assess the involvement of T-type Ca2+ channels. Cell viability was determined by the calcein assay. Key findings REN cells transiently exposed to 1–10μM Res showed increasing peaks of Ca2+ that were absent in Ca2+-...
Source: Life Sciences - February 1, 2016 Category: Biology Source Type: research

Over-expression of miR-451a can enhance the sensitivity of breast cancer cells to tamoxifen by regulating 14-3-3ζ, estrogen receptor α, and autophagy
Publication date: Available online 17 February 2016 Source:Life Sciences Author(s): Zhen-Ru Liu, Yi Song, Li-Hong Wan, Yuan-Yuan Zhang, Li-Mimg Zhou Aim To investigate the effects and mechanisms of miR-451a in the tamoxifen (TAM) resistance of breast cancer cells. Materials and methods TAM sensitive cells (MCF-7) and resistant cells (LCC2) were employed in the study. The lentivirus vectors of Lv-miR-451a, Lv-miR-451a sponge, and Lv-miR-451a NC were employed to increase or decrease the expression of miR-451a, respectively. SiRNA to 14-3-3ζ was used to inhibit expression of 14-3-3ζ. MTT assay was utilized to detect...
Source: Life Sciences - February 18, 2016 Category: Biology Source Type: research

Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells
Publication date: Available online 4 May 2016 Source:Life Sciences Author(s): Po-Min Yang, Zhi-Zhen Wu, Yu-Qi Zhang, Being-Sun Wung Aims Age-related macular degeneration (AMD) is one of the most common diseases leading to blindness in elderly people. The progression of AMD may be prevented through anti-inflammation and antioxidation in retinal pigment epithelial (RPE) cells. Lycopene, a carotenoid, has been shown to possess both antioxidative and anti-inflammatory properties. This research was conducted to detail the mechanisms of these effects of lycopene-treated RPE cells. Main methods We exposed ARPE-19 cells to ...
Source: Life Sciences - May 4, 2016 Category: Biology Source Type: research

Lysophosphatidylethanolamine acyltransferase 1/membrane-bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons Research
In this study, we examined whether LPLATs are involved in neuronal differentiation using all-trans-retinoic acid (ATRA)–treated P19C6 cells. In these cells, mRNA levels of lysophosphatidylethanolamine acyltransferase (LPEAT)-1/membrane-bound O-acyltransferase (MBOAT)-1 were higher than those in undifferentiated cells. LPEAT enzymatic activity increased with 16:0- and 18:1-CoA as acyl donors. When LPEAT1/MBOAT1 was knocked down with small interfering RNA (siRNA), outgrowth of neurites and expression of neuronal markers decreased in ATRA-treated P19C6 cells. Voltage-dependent calcium channel activity was also suppresse...
Source: FASEB Journal - June 29, 2016 Category: Biology Authors: Tabe, S., Hikiji, H., Ariyoshi, W., Hashidate-Yoshida, T., Shindou, H., Okinaga, T., Shimizu, T., Tominaga, K., Nishihara, T. Tags: Research Source Type: research

PGC-1 α is associated with C2C12 Myoblast differentiation
Abstract PGC-1 α has been implicated as an important mediator of functional capacity of skeletal muscle. However, the role of PGC-1α in myoblast differentiation remains unexplored. In the present study, we observed a significant up-regulation of PGC-1α expression during the differentiation of murine C2C12 myobl ast. To understand the biological significance of PGC-1α up-regulation in myoblast differentiation, C2C12 cells were transfected with murine PGC-1α cDNA and siRNA targeting PGC-1α, respectively. PGC-1α over-expressing clones fused to form typical myotubes with higher mRNA level of myosin heavy c hain isoform...
Source: Central European Journal of Biology - October 31, 2014 Category: Biology Source Type: research