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Total 656 results found since Jan 2013.

ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF- κB Signal Pathways
Biol Trace Elem Res. 2022 Jul 23. doi: 10.1007/s12011-022-03361-w. Online ahead of print.ABSTRACTApoptosis of kidney tubular epithelial cells contributes to diabetic kidney disease (DKD) pathophysiology, but the mechanisms are not fully understood. Zinc transporter protein member 8 (ZnT8, SLC30A8) is a susceptive gene in diabetes. Here, we aim to investigate whether ZnT8 has effects on pathophysiology of DKD. The animal groups include control, ZnT8KO mice, STZ-induced, and ZnT8-KO-STZ. STZ-induced DKD was performed in male C57BL/6 J mice and in ZnT8-KO mice. High glucose (HG)-induced apoptosis in a normal rat kidney tubula...
Source: Biological Trace Element Research - July 23, 2022 Category: Biology Authors: Yinmao Chi Xiuli Zhang Dan Liang Yue Wang Xiaoyi Cai Jiqiu Dong Lingzhi Li Zhihong Chi Source Type: research

Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF- α by reduction of fatty acid β-oxidation and anti-oxidation
Free Radic Biol Med. 2022 Sep 9:S0891-5849(22)00583-4. doi: 10.1016/j.freeradbiomed.2022.09.002. Online ahead of print.ABSTRACTTumor necrosis factor-α (TNF-α) is an inflammatory cytokine involved in cell survival, apoptosis, and homeostasis. However, the regulatory effect of TNF-α on mesenchymal stem cell (MSC) redox regulation remains unknown. The process of delaying the senescence of MSCs and maintaining antioxidation mechanism is important in transplantation therapy to treat inflammatory diseases that result from restricted immunomodulatory effects of senescent MSCs. Thus, we examined the role of TNF-α-mediated sign...
Source: Free Radical Biology and Medicine - September 12, 2022 Category: Biology Authors: Young Hyun Jung Chang Woo Chae Han Seung Chang Gee Euhn Choi Hyun Jik Lee Ho Jae Han Source Type: research

The clock gene, period, influences migratory flight and reproduction of the oriental armyworm, Mythimna separata
This article is protected by copyright. All rights reserved
Source: Insect Science - October 29, 2022 Category: Biology Authors: Jiayue Ji, Yueqiu Liu, Lei Zhang, Yunxia Cheng, David Stanley, Xingfu Jiang Tags: ORIGINAL ARTICLE Source Type: research

The involvement of hormone-sensitive lipase in all-trans retinoic acid induced cleft palate
Int J Dev Biol. 2023 Jan 20. doi: 10.1387/ijdb.220137kz. Online ahead of print.ABSTRACTAbnormally high concentrations of all-trans retinoic acid (atRA) induce cleft palate, which is accompanied by abnormal migration and proliferation of mouse embryonic palatal mesenchyme (MEPM) cells. Hormone-sensitive lipase (HSL) is involved in many embryonic development processes. The current study was designed to elucidate the mechanism of HSL in cleft palate induced by atRA. To establish a cleft palate model in Kunming mice, pregnant mice were administered atRA (70 mg/kg) by gavage at embryonic Day 10.5 (E10.5). Embryonic palates were...
Source: International Journal of Developmental Biology - January 23, 2023 Category: Biology Authors: K Zheng Q N Ye Source Type: research