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Total 656 results found since Jan 2013.

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis
Publication date: June 2018 Source:Redox Biology, Volume 16 Author(s): Yachun Han, Xiaoxuan Xu, Chengyuan Tang, Peng Gao, Xianghui Chen, Xiaofen Xiong, Ming Yang, Shikun Yang, Xuejing Zhu, Shuguang Yuan, Fuyou Liu, Li Xiao, Yashpal S. Kanwar, Lin Sun NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of patients with diabetic nephropathy (DN) is unclear. Here, we demonstrated that mtROS overproduction is accompanied by decreases in ...
Source: Redox Biology - February 20, 2018 Category: Biology Source Type: research

ROS Modifiers and NOX4 Affect the Expression of the Survivin-Associated Radio-Adaptive Response.
Abstract The survivin-associated radio-adaptive response can be induced following exposure to ionizing radiation in the dose range from 5 to 100 mGy, and its magnitude of expression is dependent upon the TP53 mutational status of cells and ROS signaling. The purpose of the study was to investigate the potential role of ROS in the development of the survivin-associated adaptive response. Utilizing human colon carcinoma HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures, the roles of inter- and intracellular ROS signaling on expression of the adaptive response as evidenced by changes...
Source: Free Radical Biology and Medicine - April 13, 2018 Category: Biology Authors: Murley JS, Arbiser JL, Weichselbaum RR, Grdina DJ Tags: Free Radic Biol Med Source Type: research

Axis of serotonin -pERK-YAP in liver regeneration
ConclusionA role of the 5-HT-pERK-YAP axis in liver regeneration emerged from our study and might be a potential target to promote regeneration and injury repair.
Source: Life Sciences - August 21, 2018 Category: Biology Source Type: research

AMPK/PGC1 α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis.
AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med. 2018 Aug 30;: Authors: Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, Reiter RJ, Qiao S, Yuan J Abstract Doxorubicin (DOX) is a highly effective anticancer anthracycline drug, but its side effects at the level of the heart has limited its widespread clinical application. Melatonin is a documented potent antioxidant, nontoxic and cardioprotective agent, and it is involved in maintaining mitochondrial homeostasis and function. The present study esta...
Source: Free Radical Biology and Medicine - August 30, 2018 Category: Biology Authors: Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, Reiter RJ, Qiao S, Yuan J Tags: Free Radic Biol Med Source Type: research

Plant mRNA decay: extended roles and potential determinants.
Abstract The decay of mRNA in plants is tightly controlled and shapes the transcriptome. The roles of this process are to digest RNA as well as to suppress exogenous and endogenous gene silencing by preventing siRNA generation. Recent evidence suggests that mRNA decay also regulates the accumulation of the putative 3' fragment-derived long non-coding RNAs (3'lncRNAs). The generation of siRNA or 3'lncRNA from a selective subset of mRNAs raises a fundamental question of how the mRNA decay machineries select and determine their substrate transcripts for distinctive decay destiny. Evidence for potential mRNA decay det...
Source: Current Opinion in Plant Biology - September 14, 2018 Category: Biology Authors: Li B, Wu H, Guo H Tags: Curr Opin Plant Biol Source Type: research

PGC-1 α is associated with C2C12 Myoblast differentiation
AbstractPGC-1 α has been implicated as an important mediator of functional capacity of skeletal muscle. However, the role of PGC-1α in myoblast differentiation remains unexplored. In the present study, we observed a significant up-regulation of PGC-1α expression during the differentiation of murine C2C12 myobl ast. To understand the biological significance of PGC-1α up-regulation in myoblast differentiation, C2C12 cells were transfected with murine PGC-1α cDNA and siRNA targeting PGC-1α, respectively. PGC-1α over-expressing clones fused to form typical myotubes with higher mRNA level of myosin heavy c hain isoform I...
Source: Central European Journal of Biology - November 1, 2014 Category: Biology Source Type: research

Mini Review: Revisiting Mobile RNA Silencing In Plants
This article revisits our present understanding of intercellular and systemic non-cell autonomous RNA silencing, and summarises current debates on RNA signals for mobile silencing. In particular, we discuss new evidence on siRNA mobility, a DCL2-dependent genetic network for mobile silencing and its potential biological relevance as well as 22 nt siRNA being a mobile signal for non-cell-autonomous silencing in both Arabidopsis and Nicotiana benthamiana. This sets up a new trend in unravelling genetic components and small RNA signal molecules for mobile silencing in (across) plants and other organisms of different kingdom...
Source: Plant Science - November 3, 2018 Category: Biology Source Type: research

Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches
Publication date: Available online 16 November 2018Source: Redox BiologyAuthor(s): MJ López-Grueso, González-Ojeda, R Requejo, McDonagh, CA Fuentes-Almagro, J Muntané, JA Bárcena, CA PadillaAbstractThe aim of the present study was to define the role of Trx and Grx on metabolic thiol redox regulation and identify their protein and metabolite targets. The hepatocarcinoma-derived HepG2 cell line under both normal and oxidative/nitrosative conditions by overexpression of NO synthase (NOS3) was used as experimental model. Grx1 or Trx1 silencing caused conspicuous changes in the redox proteome reflected by significant change...
Source: Redox Biology - November 17, 2018 Category: Biology Source Type: research

Inhibiting Inflammation and Modulating Oxidative Stress in Oxalate-Induced Nephrolithiasis with the Nrf2 Activator Dimethyl Fumarate.
This study aimed to investigate whether nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also called Nfe2l2) induced by dimethyl fumarate (DMF) could protect renal epithelial cells against oxalate-mediated injury both in vivo and in vitro. Glyoxylic acid monohydrate was intraperitoneally injected into Sprague-Dawley rats with or without intragastric administration of DMF. We showed that calcium oxalate crystallisation, accompanied by overexpression of oxidant species and inflammatory cytokines and apoptosis in the rat kidney, was partially reversed by treatment with DMF. Furthermore, oxalate induced a reduction in cell v...
Source: Free Radical Biology and Medicine - December 29, 2018 Category: Biology Authors: Zhu J, Wang Q, Li C, Lu Y, Hu H, Qin B, Xun Y, Zhu Y, Wu Y, Zhang J, Wang S Tags: Free Radic Biol Med Source Type: research

LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats
Publication date: Available online 23 January 2019Source: Redox BiologyAuthor(s): Jianhua Peng, Jinwei Pang, Lei Huang, Budbazar Enkhjargal, Tongyu Zhang, Jun Mo, Pei Wu, Weilin Xu, Yuchun Zuo, Jun Peng, Gang Zuo, Ligang Chen, Jiping Tang, John H. Zhang, Yong JiangAbstractWhite matter injury (WMI) is associated with motor deficits and cognitive dysfunctions in subarachnoid hemorrhage (SAH) patients. Therapeutic strategy targeting WMI would likely improve the neurological outcomes after SAH. Low-density lipoprotein receptor-related protein-1 (LRP1), a scavenger receptor of apolipoprotein E (apoE), is able to modulate microg...
Source: Redox Biology - January 24, 2019 Category: Biology Source Type: research

Honokiol induces endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells
Publication date: Available online 29 January 2019Source: Life SciencesAuthor(s): Jianfei Zhu, Shuonan Xu, Wenli Gao, Jianyu Feng, Guolong ZhaoAbstractAimsHonokiol is a hydroxylated biphenyl natural product and displays potent antitumor activity against several cancers including prostate cancer, melanoma, leukemia, and colorectal cancer. The present study was to investigate the in vitro activity of honokiol against A549 and 95-D human lung cancer cells.Main methodsA549 and 95-D cells were used with honokiol treatment. Cell viability was determined by CCK-8 assay. The cell migration and apoptosis were evaluated by wound hea...
Source: Life Sciences - January 29, 2019 Category: Biology Source Type: research

AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model
Publication date: Available online 18 February 2019Source: Life SciencesAuthor(s): Xuyang Wang, Jinyu Pan, Hui Liu, Mingjun Zhang, Dian Liu, Lu Lu, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang AnAbstractAimsAbsent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its potential molecular mechanism.Main methodsSprague-Dawley rats were randomly divided into 4 groups: Control,...
Source: Life Sciences - February 18, 2019 Category: Biology Source Type: research

Z-Guggulsterone attenuates glucocorticoid-induced osteoporosis through activation of Nrf2/HO-1 signaling
Publication date: Available online 21 March 2019Source: Life SciencesAuthor(s): Yier Xu, Jian Guan, Jianyu Xu, Shuilin Chen, Guicai SunAbstractAimsThe present study aims to investigate the protective effect and underlying mechanism of Z-Guggulsterone (Z-GS), an active component from myrrh, on glucocorticoid-induced osteoporosis (GIO).Main methodsGIO rats were used to simulate osteoporosis in vivo while MC3T3-E1 cells were induced to osteoblast differentiation and treated with dexamethasone to simulate osteoporosis in vitro. The rats and cells were treated with Z-GS according to the protocol. The bone mineral density, biome...
Source: Life Sciences - March 21, 2019 Category: Biology Source Type: research

Endoplasmic reticulum-associated degradation potentiates the infectivity of influenza A virus by regulating the host redox state.
Abstract During influenza A virus (IAV) infection, significant effects of oxidative stress often emerge due to the disruption of the redox balance. Reactive oxygen species (ROS) generated during IAV infection have been known to exert various effects on both the virus and host tissue. However, the mechanisms underlying the accumulation of ROS and their physiological significance in IAV infection have been extensively studied but remain to be fully understood. Here, we show that the levels of Sp1, a key controller of Cu-Zn superoxide dismutase (SOD1) gene expression, and SOD1 are mainly dependent upon the activity o...
Source: Free Radical Biology and Medicine - March 20, 2019 Category: Biology Authors: Jung KI, Shin N, Ko DH, Pyo CW, Choi SY Tags: Free Radic Biol Med Source Type: research

FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice
Publication date: Available online 3 April 2019Source: Redox BiologyAuthor(s): Dae Hyun Kim, Bonggi Lee, Jaewon Lee, Mi Eun Kim, Jun Sik Lee, Jae Heun Chung, Byung Pal Yu, H. Henry Dong, Hae Young ChungAbstractFoxO has been proposed to play a role in the promotion of insulin resistance, and inflammation. FoxO is a pro-inflammatory transcription factor that is a key mediator of generation of inflammatory cytokines such as IL-1β in the liver. However, the detailed association of FoxO6 with insulin resistance and age-related inflammation has not been fully documented. Here, we showed that FoxO6 was elevated in the livers of ...
Source: Redox Biology - April 4, 2019 Category: Biology Source Type: research