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Total 187 results found since Jan 2013.

Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway
In this study, we investigated the role and underlying molecular mechanism of Tau on protein synthesis and proliferation of C2C12 myoblast cells. Cells were treated with Tau (0, 60, 120, 180 and 240 μM) for 24 h. Tau dose-dependently promoted protein synthesis, cell proliferation, mTOR phosphorylation, and also AT-rich interaction domain 4B (ARID4B) expression, with the best stimulatory effects at 120 μM. LY 294002 treatment showed that Tau promoted ARID4B expression in a PI3K-dependent manner. ARID4B knockdown (by siRNA transfection for 24 h) prevented Tau from stimulating protein synthesis and cell proliferation, where...
Source: The British Journal of Nutrition - December 9, 2021 Category: Nutrition Authors: Qi Hao Lulu Wang Minghui Zhang Zhe Wang Meng Li Xuejun Gao Source Type: research

Organic Cation Transporter I and Na+/taurocholate Co ‐Transporting Polypeptide are Involved in Retrorsine‐ and Senecionine‐Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirmed previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - November 26, 2021 Category: Food Science Authors: Anne ‐Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Pötz, Albert Braeuning, Stefanie Hessel‐Pras Tags: Research Article Source Type: research

The BMSC-derived exosomal lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis
The exosomal long noncoding RNAs (lncRNAs) have been reported to have cardioprotective effects on ischemia-reperfusion (I/R) injury by hindering ferroptosis, but the role of lncRNA Mir9-3 host gene (Mir9-3hg) in cardiac I/R injury remains unclear. Exosomes were extracted from mouse bone marrow mesenchymal stem cells (BMSCs) and identified by detecting the exosome specific marker levels, and the results showed that Mir9-3hg was highly expressed in BMSCs-Exo. Hypoxia/reoxygenation (H/R)-treated HL-1 mouse cardiomyocytes were incubated with exosomes extracted from BMSCs transfected with Mir9-3hg siRNA.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 2, 2021 Category: Nutrition Authors: Jian-Kai Zhang, Zhi Zhang, Zi-ao Guo, Yuan Fu, Xiao-Jia Chen, Wei-Jie Chen, Hong-Fu Wu, Xiao-Jun Cui Source Type: research

Identification of Stabilization of Malvid Anthocyanins and Antioxidant Stress Activation via the AMPK/SIRT1 Signaling Pathway
This study aims to identify the structure of stable mallow-like anthocyanins and to determine the effect of these stable anthocyanins on human umbilical vein endothelial cells (HUVECs) with H2O2-induced oxidative damage and the signaling pathway involved. The products of malvid anthocyanins and caffeic acid bonding were identified and analyzed using ultra-high performance liquid chromatography-quadrupole-Orbitrap mass spectrometry (UPLC-Q-Orbitrap MS/MS). The bonding products were malvidin-3-O-guaiacol (Mv3C), malvidin-3-O-(6″-O-caffeoyl)-glucoside (Mv3CG), and malvidin-3-O-(6″-O-caffeoyl)-5-diglucoside (Mv3C5G). An ox...
Source: Evidence-based Complementary and Alternative Medicine - September 6, 2021 Category: Complementary Medicine Authors: Fei Zheng Hai Xue Bi-Xiang Wang Man-Yu Wu Dong-Xia Chen Hao Yue Lian-Kui Wen Yang He Source Type: research

Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq
ConclusionsThe 3 differentially expressed circRNAs may play an important role in the process of AST promoting cholesterol efflux and may be used as biomarkers to prevent AS.
Source: Genes and Nutrition - August 28, 2021 Category: Nutrition Source Type: research

Quercetin Impairs HuR-Driven Progression and Migration of Triple Negative Breast Cancer (TNBC) Cells
Nutr Cancer. 2021 Jul 19:1-14. doi: 10.1080/01635581.2021.1952628. Online ahead of print.ABSTRACTIn the present study, we have explored the prognostic value of HuR gene as well as protein in breast cancers. Furthermore, we have also investigated the HuR therapeutic relevance in TNBCs, which is an aggressive breast cancer subtype. Using an online meta-analysis tool, we found that HuR protein overexpression positively correlates with reduced overall survival of TNBC patients (p = 0.028). Furthermore, we demonstrated that the TNBC breast cancer cell lines i.e., MDA-MB-231 and MDA-MB-468 are good model systems to study HuR pro...
Source: Nutrition and Cancer - July 19, 2021 Category: Cancer & Oncology Authors: Sheikh Mohammad Umar Sushmita Patra Akanksha Kashyap Arundhathi Dev J R Lalit Kumar Chandra Prakash Prasad Source Type: research

Delivery of siHIF ‐1α to Reconstruct Tumor Normoxic Microenvironment for Effective Chemotherapeutic and Photodynamic Anticancer Treatments
An integrated amphiphilic delivery system (RSCD) based on Angiotensin II receptor blocker candesartan for siRNA against the hypoxia-inducible factor-1 alpha (HIF-1 α) is fabricated, aiming at both vascular and cellular “relaxation” to reconstruct a tumor normoxic microenvironment, which significantly improves the chemotherapeutic and photodynamic anticancer treatment. AbstractThe tumor hypoxic microenvironment not only induces genetic and epigenetic changes in tumor cells, immature vessels formation for oxygen demand, but also compromises the efficiency of therapeutic interventions. On the other hand, conventional the...
Source: Small - May 25, 2021 Category: Nanotechnology Authors: Xiaobing Chen, Rongrong Jin, Qian Jiang, Qunjie Bi, Ting He, Xu Song, Matthias Barz, Hua Ai, Xintao Shuai, Yu Nie Tags: Research Article Source Type: research

Homocysteine-induced decrease in HUVEC cells ’ resistance to oxidative stress is mediated by Akt-dependent changes in iron metabolism
ConclusionsThese data indicate that Hcy induces an increase in cellular ferritin level, and the process is mediated by alterations in Akt-FOXO3a signaling pathway.
Source: European Journal of Nutrition - March 24, 2021 Category: Nutrition Source Type: research

Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR- γ and SOCS1 induction.
Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction. J Clin Biochem Nutr. 2020 Nov;67(3):248-256 Authors: Park JM, An JM, Han YM, Surh YJ, Hwang SJ, Kim SJ, Hahm KB Abstract The health beneficial effects of walnut plentiful of n-3 polyunsaturated fatty acid had been attributed to its anti-inflammatory and anti-oxidative properties against various clinical diseases. Since we have published Fat-1 transgenic mice overexpressing 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric pat...
Source: Journal of Clinical Biochemistry and Nutrition - December 11, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Elevated hippocampal CD24 in astrocytes participates in neural regeneration possibly via activating SHP2/ERK pathway after experimental traumatic brain injury in mice.
Authors: Gao X, Wang H, Gao YY, Zhou XM, Tao T, Liu GJ, Zhou Y, Li W, Hang CH Abstract Massive neuron loss is the key reason for poor prognoses in patients with traumatic brain injury (TBI), and astrocytes function as nutrition-providing neurons. Therefore, researchers must determine the potential role of astrocytes in neural regeneration after TBI. Our previous studies established that upregulating CD24 in the hippocampus might improve cognitive functions after TBI. However, whether CD24 in hippocampal astrocytes is involved in neural regeneration after TBI remains unknown. Therefore, we detected the CD24 expressi...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Improved Glucose Intolerance Through a Distinct Mouse Olfactory Receptor 23 ‐Induced Signaling Pathway Mediating Glucose Uptake In Myotubes and Adipocytes
ConclusionsThese findings suggest that MOR23 is a novel factor for the regulation of glucose uptake and whole ‐body glucose homeostasis and has therapeutic potential for diabetes treatment.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - September 10, 2020 Category: Food Science Authors: Wesuk Kang, Kelun Zhang, Tao Tong, Taesun Park Tags: Research Article Source Type: research

Identification and functional characterization of natural resistance-associated macrophage protein 2 from sea cucumber Apostichopus japonicus.
In this study, a unique echinoderm Nramp2 was identified from sea cucumber Apostichopus japonicus (designated as AjNramp2). The cDNA sequence of AjNramp2 was 2360 bp, with a putative open reading frame of 1713 bp, encoding a typical Nramp domain containing protein with 570 amino acid residues. Structural analysis revealed that AjNramp2 consisted of highly conserved helix regions similar with the human Nramp2. Spatial expression analysis revealed that AjNramp2 was ubiquitously expressed in all examined tissues, with the highest level found in the intestine. Immunohistochemistry assay showed that AjNramp2 was mainly located ...
Source: Developmental and Comparative Immunology - August 21, 2020 Category: Allergy & Immunology Authors: Huang B, Lv Z, Li Y, Li C Tags: Dev Comp Immunol Source Type: research

Embryonic MTHFR contributes to blastocyst development
ConclusionThe results indicate that embryonic MTHFR is indispensable for normal blastocyst development. The findings provide insight into the debatable roles of MTHFR in fertility and may be applicable for the improvement of care for early embryos via modulation of surrounding folate-related nutritional conditions in vitro and/or in utero, depending on the parental and embryonicMTHFR genotype.
Source: Journal of Assisted Reproduction and Genetics - August 6, 2020 Category: Reproduction Medicine Source Type: research

Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells.
Abstract Cancer stem cell theory has been proposed to explain tumor heterogeneity and the carcinogenesis process. Highly tumorigenic lung cancer stem cells develop resistance to cisplatin (CDDP), a common chemotherapy drug. Herein, we attempted to clarify whether apigenin (API) can improve the antitumor efficiency of CDDP in lung cancer using cancer stem cells. Lung cancer stem cells were identified as CD 133 positive cancer cells in non-small cell lung cancer (NSCLC) A549, H1299 cells and CDDP-resistant NSCLC A549R cells. The cytotoxic effect of API was measured in CDDP-treated A549, H1299, and A549R cells. API r...
Source: Nutrition and Cancer - August 5, 2020 Category: Cancer & Oncology Authors: Li Y, Chen X, He W, Xia S, Jiang X, Li X, Bai J, Li N, Chen L, Yang B Tags: Nutr Cancer Source Type: research

Purple sweet potato color protects against hepatocyte apoptosis through Sirt1 activation in high-fat-diet-treated mice.
Conclusion: PSPC protected against HFD-induced hepatic apoptosis by promoting Sirt1- dependent inhibition of p53-apoptotic pathway and facilitation of Akt survival pathway. This study indicates that PSPC is a candidate for nutritional intervention of NAFLD. PMID: 32110174 [PubMed - as supplied by publisher]
Source: Food and Nutrition Research - February 29, 2020 Category: Nutrition Authors: Su W, Zhang C, Chen F, Sui J, Lu J, Wang Q, Shan Q, Zheng G, Lu J, Sun C, Fan S, Wu D, Zhang Z, Zheng Y Tags: Food Nutr Res Source Type: research