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Total 187 results found since Jan 2013.

Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - February 17, 2020 Category: Food Science Authors: Md Alauddin, Toshiyuki Okumura, Janet Rajaxavier, Shayan Khozooei, Simone P öschel, Satoru Takeda, Yogesh Singh, Sara Y Brucker, Diethelm Wallwiener, André Koch, Madhuri S Salker Tags: Research Article Source Type: research

Epigallocatechin Gallate Induces Upregulation of LDL Receptor via the 67  kDa Laminin Receptor‐Independent Pathway in HepG2 Cells
ConclusionEGCG activates LDLR expression via 67LR ‐independent pathway in HepG2 cells.
Source: Molecular Nutrition and Food Research - February 5, 2020 Category: Food Science Authors: Kumiko Zanka, Yuya Kawaguchi, Yudai Okada, Satoshi Nagaoka Tags: Research Article Source Type: research

A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis.
Abstract Almost a billion people worldwide are chronically undernourished. Herein, using a mouse model of coxsackievirus B3 (CVB3) infection, we report that a single day of food restriction (FR) markedly increases susceptibility to attenuated enterovirus infection, replication, and disease. These "pro-viral" effects, which are rapidly-reversed by the restoration of food, are mediated by several genes whose expression is altered by FR, and which support CVB3 replication. Central to this is TFEB, a protein whose expression and activation status are rapidly increased by FR. TFEB, which regulates the transcription of ...
Source: Autophagy - February 3, 2020 Category: Cytology Authors: Alirezaei M, Flynn CT, Garcia SD, Kimura T, Whitton JL Tags: Autophagy Source Type: research

Epigallocatechin Gallate Induces Up ‐Regulation of LDL Receptor via the 67 kDa Laminin Receptor‐Independent Pathway in HepG2 Cells
ConclusionEGCG activates LDLR expression via 67LR ‐independent pathway in HepG2 cells.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Kumiko Zanka, Yuya Kawaguchi, Yudai Okada, Satoshi Nagaoka Tags: Research Article Source Type: research

Gut metabolite, Urolithin A decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUrolithin A leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary Urolithin A in cancer prevention or as adjuvant therapy is promising.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Md Alauddin, Toshiyuki Okumura, Janet Rajaxavier, Shayan Khozooei, Simone P öschel, Satoru Takeda, Yogesh Singh, Sara Y Brucker, Diethelm Wallwiener, André Koch1, Madhuri S Salker Tags: Research Article Source Type: research

Propionate promotes vitamin D receptor expression via yes-associated protein in rats with short bowel syndrome.
In this study, we aimed to investigate the effect of propionate on the expression of the vitamin D receptor (VDR) in the small intestine of rats with SBS. Firstly, IEC-6 (intestinal epithelioid cell line No. 6) cells were incubated in vitro with 1 mM sodium propionate for 24 h. This resulted in a significant increase in the expression of VDR and yes-associated protein (YAP) compared with that in the control group. Transfection of IEC-6 cells with YAP siRNA significantly down-regulated the expression of VDR. By contrast, after incubating IEC-6 cells with lysophosphatidic acid, an agonist of YAP, upregulation of VDR and...
Source: Biochemical and Biophysical Research communications - January 11, 2020 Category: Biochemistry Authors: Lin H, Huang Y, Tian T, Wang P, Li Y Tags: Biochem Biophys Res Commun Source Type: research

TRIM13 inhibits cell migration and invasion in clear-cell renal cell carcinoma.
This study explored the clinical significance and biological function of TRIM13 in human RCC. Western blot analyses and Immunohistochemical were performed in RCC tissues. The clinical relevance of TRIM13 in RCC was evaluated by immunohistochemical staining using tissue microarray. The role of TRIM13 in migration was studied in renal cell carcinoma cell lines of 786-O through knocking down TRIM13 with siRNA and over-expression of TRIM13. The regulation of TRIM13 on migration and invasion were determined by wound-healing and transwell assays. Western blot analyses showed that TRIM13 expression was dramatically decreased in R...
Source: Nutrition and Cancer - November 23, 2019 Category: Cancer & Oncology Authors: Li H, Qu L, Zhou R, Wu Y, Zhou S, Zhang Y, Cheng B, Ni J, Huang H, Hou J Tags: Nutr Cancer Source Type: research

Oleic acid promotes cell invasion through an integrin-linked kinase signaling pathway in renal cell carcinoma.
In this study, we further observe the effects of OA on cell invasion of RCC and the potential mechanism by which OA worked was determined. The transwell invasion assay showed OA increased cell invasion of RCC in a dose-dependent manner. Western blotting results indicated ILK, COX-2, and MMP-9 proteins were involved for their high expressions and these effects were reversed when down-regulating the expression of ILK by special siRNA. The MMPs inhibitor GM6001 could weaken the abilities of OA on RCC cells invasion. These results suggested MUFA indeed affected cell invasion of RCC, which was depended by the regulation of ILK ...
Source: Nutrition and Cancer - September 30, 2019 Category: Cancer & Oncology Authors: Liu ZH, Qing CP, Sheng ZZ, Li GZ, Man LB, Xu T Tags: Nutr Cancer Source Type: research

Punicalagin, a Pomegranate ‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway
ConclusionsPCG ameliorated obesity and obesity ‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - August 23, 2019 Category: Food Science Authors: Bobin Kang, Chae Young Kim, Jisu Hwang, Kyungae Jo, Singeun Kim, Hyung Joo Suh, Hyeon ‐Son Choi Tags: Research Article Source Type: research

Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins
Publication date: Available online 5 August 2019Source: Life SciencesAuthor(s): Hu Li, Rahmani Mohammad Malyar, Nianhui Zhai, Hong Wang, Kai Liu, Dandan Liu, Cuiling Pan, Fang Gan, Kehe Huang, Jinfeng Miao, Xingxiang ChenAbstractAimsThe present study was to investigate the protective effects of Zn supplementation in OTA-induced apoptosis of Madin-Darby canine kidney (MDCK) epithelial cells and explore the potential mechanisms. Aiming to provides a new insight into the treatment strategy of OTA-induced nephrotoxicity by nutritional regulation.Main methodsInitially, through MTT and LDH assay revealed that Zn supplementation ...
Source: Life Sciences - August 18, 2019 Category: Biology Source Type: research

Attenuation of Palmitic Acid –Induced Lipotoxicity by Chlorogenic Acid through Activation of SIRT1 in Hepatocytes
ConclusionCollectively, these findings show that supplementation with CGA protects hepatocytes from FFA ‐induced lipotoxicity through activation of SIRT1, which reverses the oxidative stress and dysfunction of mitochondrial biogenesis directly.
Source: Molecular Nutrition and Food Research - June 12, 2019 Category: Food Science Authors: Lele Yang, Jinchao Wei, Feiya Sheng, Peng Li Tags: Research Article Source Type: research

Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPAR α pathway
This study investigated the preventive and therapeutic effects of RSV on high-fat diet (HFD)-induced NAFLD in rats and palmitate acid (PA)-induced hepatocyte steatosis in HepG2 cells. Hepatocytes were incubated with inhibitors of peroxisome proliferator-activated receptor α (PPARα) or short interfering RNAs (siRNAs) targeting PPARα, AMP-activated protein kinase (AMPK), and protein kinase A (PKA) to determine the underlying mechanisms. We found that RSV noticeably ameliorated HFD-induced hepatic steatosis in rats and inhibited PA-induced lipid accumulation in HepG2 cells. Moreover, RSV improved lipid metabolism, enhanced...
Source: Applied Physiology, Nutrition, and Metabolism - June 6, 2019 Category: Physiology Authors: Yujie Huang Hedong Lang Ka Chen Yong Zhang Yanxiang Gao Li Ran Long Yi Mantian Mi Qianyong Zhang Source Type: research

Attenuation of Palmitic Acid ‐Induced Lipotoxicity by Chlorogenic Acid Through Activation of SIRT1 in Hepatocytes
ConclusionCollectively, these findings show that supplementation with CGA protected hepatocytes from FFAs ‐induced lipotoxicity through activation of SIRT1, which reversed the oxidative stress and dysfunction of mitochondrial biogenesis directly.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - June 4, 2019 Category: Food Science Authors: Lele Yang, Jinchao Wei, Feiya Sheng, Peng Li Tags: Research Article Source Type: research

Chrysanthemum extract attenuates hepatotoxicity via inhibiting oxidative stress in vivo and in vitro.
Conclusions: BZE plays an important role in preventing hepatotoxicity by inhibiting oxidative stress and apoptosis through activation of Nrf2 signaling. BZE could be developed as an effective functional food for protecting the liver. PMID: 31024225 [PubMed]
Source: Food and Nutrition Research - April 27, 2019 Category: Nutrition Authors: Tian Z, Jia H, Jin Y, Wang M, Kou J, Wang C, Rong X, Xie X, Han G, Pang X Tags: Food Nutr Res Source Type: research

An Ensemble Strategy to Predict Prognosis in Ovarian Cancer Based on Gene Modules
Conclusion Considering the heterogeneity and complexity of ovarian cancer, we demonstrated a new method to predict the prognosis of ovarian cancer based on the clustering information and gene co-expression network in each subtype of cancer patients. We divided the ovarian cancer data into three subtypes by clustering analysis and we found that the survival risks in these three subtypes were significantly different. We mined the important communities based on the co-expression networks in each subtype. There are 50, 73, and 92 communities in the first, second and third subtype, respectively. Next, we constructed a new ense...
Source: Frontiers in Genetics - April 23, 2019 Category: Genetics & Stem Cells Source Type: research