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Total 187 results found since Jan 2013.

Butyrate Improves Porcine Endometrial Epithelial Cell Receptivity via Enhancing Acetylation of Histone H3K9
ConclusionThe findings reveal that butyrate improves endometrial epithelial cell receptivity by enhancing the acetylation of histone H3K9, which shows nutritional regulation and therapeutic potential for poor uterine receptivity and difficulty in embryo implantation.
Source: Molecular Nutrition and Food Research - July 8, 2023 Category: Food Science Authors: Qianhong Ye, Haoyu Li, Baoyang Xu, Ziyi He, Xianghua Yan Tags: Research Article Source Type: research

mTORC2 ‐AKT‐LAT1 signalling participates in methionine‐induced β‐CASEIN expression in mammary epithelial cells of dairy cows
This study investigated the role of the mammalian target of rapamycin complex 2 (mTORC2)-protein kinase B (AKT) signalling in methionine (Met)-induced L-type amino acid transporter 1 (LAT1) expression and milk protein production. Primary mammary epithelial cells (MECs) from mammary parenchymal tissues of three lactating cows and MAC-T bovine MECs were cultured with or without 0.6  mM Met. Rapamycin-insensitive companion of mTOR (RICTOR) siRNA, the mTORC1 inhibitor rapamycin and the AKT activator SC79 were used to evaluate the effects of mTORC2-AKT signalling on Met-induced LAT1 expression and function. Each experiment wa...
Source: Journal of Animal Physiology and Animal Nutrition - April 6, 2023 Category: Zoology Authors: Xiaoyu Duan, Chuanping Liu, Xiaoqing Gong, Yang Yang, Hongtao Jiao, Ye Lin, Xiaoming Hou Tags: ORIGINAL ARTICLE Source Type: research

mTORC2 ‐AKT‐LAT1 Signalling Participates in Methionine‐induced β‐CASEIN Expression in Mammary Epithelial Cells of Dairy Cows
This study investigated the role of the mammalian target of rapamycin complex 2 (mTORC2)-protein kinase B (AKT) signalling in methionine (Met)-induced L-type amino acid transporter 1 (LAT1) expression and milk protein production. Primary mammary epithelial cells (MECs) from mammary parenchymal tissues of 3 lactating cows and MAC-T bovine MECs were cultured with or without 0.6 mM Met. Rapamycin-insensitive companion of mTOR (RICTOR) siRNA, the mTORC1 inhibitor rapamycin and the AKT activator SC79 were used to evaluate the effects of mTORC2-AKT signalling on Met-induced LAT1 expression and function. Each experiment was perfo...
Source: Journal of Animal Physiology and Animal Nutrition - March 25, 2023 Category: Zoology Authors: Xiaoyu Duan, Chuanping Liu, Xiaoqing Gong, Yang Yang, Hongtao Jiao, Ye Lin, Xiaoming Hou Tags: ORIGINAL ARTICLE Source Type: research

Farnesoid X Receptor (FXR) Regulates mTORC1 Signaling and Autophagy by Inhibiting SESN2 Expression
ConclusionThese results indicate that FXR-induced decrease in SESN2 expression and activation of the mTORC1 pathway could control autophagy and be explored as potential therapeutic targets for enterohepatic and metabolic disorders.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 31, 2023 Category: Food Science Authors: GuoYan Wang, Lei Chen, SenLin Qin, HuiJun Geng, Chao Xia, YiNing Zheng, XinJian Lei, Jun Zhang, ShengRu Wu, JunHu Yao, Lu Deng Tags: Research Article Source Type: research

Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability
by Christina M. Kelliher, Elizabeth-Lauren Stevenson, Jennifer J. Loros, Jay C. Dunlap Compensation is a defining principle of a true circadian clock, where its approximately 24-hour period length is relatively unchanged across environmental conditions. Known compensation effectors directly regulate core clock factors to buffer the oscillator ’s period length from variables in the environment. Temperature Compensation mechanisms have been experimentally addressed across circadian model systems, but much less is known about the related process of Nutritional Compensation, where circadian period length is maintained acros...
Source: PLoS Biology: Archived Table of Contents - January 5, 2023 Category: Biology Authors: Christina M. Kelliher Source Type: research

Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1 α in mouse soleus muscles
J Clin Biochem Nutr. 2022 Sep;71(2):112-121. doi: 10.3164/jcbn.21-163. Epub 2022 May 26.ABSTRACTDietary β-carotene induces muscle hypertrophy and prevents muscle atrophy in red slow-twitch soleus muscles, but not in white fast-twitch extensor digitorum longus (EDL) muscles and gastrocnemius muscles. However, it remains unclear why these beneficial effects of β-carotene are elicited in soleus muscles. To address this issue, we focused on carotenoid transporters in skeletal muscles. In mice, Cd36 mRNA levels were higher in red muscle than in white muscle. The siRNA-mediated knockdown of CD36 decreased β-carotene uptake in...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Tomoya Kitakaze Takashi Sugihira Hiromichi Kameyama Asami Maruchi Yasuyuki Kobayashi Naoki Harada Ryoichi Yamaji Source Type: research

25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research

Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1 α in mouse soleus muscles
J Clin Biochem Nutr. 2022 Sep;71(2):112-121. doi: 10.3164/jcbn.21-163. Epub 2022 May 26.ABSTRACTDietary β-carotene induces muscle hypertrophy and prevents muscle atrophy in red slow-twitch soleus muscles, but not in white fast-twitch extensor digitorum longus (EDL) muscles and gastrocnemius muscles. However, it remains unclear why these beneficial effects of β-carotene are elicited in soleus muscles. To address this issue, we focused on carotenoid transporters in skeletal muscles. In mice, Cd36 mRNA levels were higher in red muscle than in white muscle. The siRNA-mediated knockdown of CD36 decreased β-carotene uptake in...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Tomoya Kitakaze Takashi Sugihira Hiromichi Kameyama Asami Maruchi Yasuyuki Kobayashi Naoki Harada Ryoichi Yamaji Source Type: research

25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research

Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1 α in mouse soleus muscles
J Clin Biochem Nutr. 2022 Sep;71(2):112-121. doi: 10.3164/jcbn.21-163. Epub 2022 May 26.ABSTRACTDietary β-carotene induces muscle hypertrophy and prevents muscle atrophy in red slow-twitch soleus muscles, but not in white fast-twitch extensor digitorum longus (EDL) muscles and gastrocnemius muscles. However, it remains unclear why these beneficial effects of β-carotene are elicited in soleus muscles. To address this issue, we focused on carotenoid transporters in skeletal muscles. In mice, Cd36 mRNA levels were higher in red muscle than in white muscle. The siRNA-mediated knockdown of CD36 decreased β-carotene uptake in...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Tomoya Kitakaze Takashi Sugihira Hiromichi Kameyama Asami Maruchi Yasuyuki Kobayashi Naoki Harada Ryoichi Yamaji Source Type: research

25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research

Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1 α in mouse soleus muscles
J Clin Biochem Nutr. 2022 Sep;71(2):112-121. doi: 10.3164/jcbn.21-163. Epub 2022 May 26.ABSTRACTDietary β-carotene induces muscle hypertrophy and prevents muscle atrophy in red slow-twitch soleus muscles, but not in white fast-twitch extensor digitorum longus (EDL) muscles and gastrocnemius muscles. However, it remains unclear why these beneficial effects of β-carotene are elicited in soleus muscles. To address this issue, we focused on carotenoid transporters in skeletal muscles. In mice, Cd36 mRNA levels were higher in red muscle than in white muscle. The siRNA-mediated knockdown of CD36 decreased β-carotene uptake in...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Tomoya Kitakaze Takashi Sugihira Hiromichi Kameyama Asami Maruchi Yasuyuki Kobayashi Naoki Harada Ryoichi Yamaji Source Type: research

25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research

Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1 α in mouse soleus muscles
J Clin Biochem Nutr. 2022 Sep;71(2):112-121. doi: 10.3164/jcbn.21-163. Epub 2022 May 26.ABSTRACTDietary β-carotene induces muscle hypertrophy and prevents muscle atrophy in red slow-twitch soleus muscles, but not in white fast-twitch extensor digitorum longus (EDL) muscles and gastrocnemius muscles. However, it remains unclear why these beneficial effects of β-carotene are elicited in soleus muscles. To address this issue, we focused on carotenoid transporters in skeletal muscles. In mice, Cd36 mRNA levels were higher in red muscle than in white muscle. The siRNA-mediated knockdown of CD36 decreased β-carotene uptake in...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Tomoya Kitakaze Takashi Sugihira Hiromichi Kameyama Asami Maruchi Yasuyuki Kobayashi Naoki Harada Ryoichi Yamaji Source Type: research