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Total 187 results found since Jan 2013.

Intracellular ferritin heavy chain plays the key role in artesunate-induced ferroptosis in ovarian serous carcinoma cells
In conclusion, enhancement of ferritinophagy is an important step involved in the mechanism of Artesunate-induced ferroptosis, and ferritin heavy chain levels may contribute to the regulation of sensitivity in Artesunate-induced ferroptosis in ovarian serous carcinoma cells.PMID:35903602 | PMC:PMC9309081 | DOI:10.3164/jcbn.21-82
Source: Journal of Clinical Biochemistry and Nutrition - July 29, 2022 Category: Nutrition Authors: Tiger Koike Motoki Takenaka Noriko Suzuki Yoko Ueda Minako Mori Tasuku Hirayama Hideko Nagasawa Ken-Ichirou Morishige Source Type: research

Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cells
ConclusionDHA can effectively promote ferroptosis-mediated tumor killing by increasing intracellular lipid peroxidation. Both ALOX5 dependent and independent pathways are involved in DHA-FIN induced ferroptosis. And during this process, free DHA plays an important role.
Source: European Journal of Nutrition - July 9, 2022 Category: Nutrition Source Type: research

GSE200983 Effect of O-GlcNAc Transferase (OGT) siRNA in trophoblastic BeWo cells
Contributors : Stephanie Olivier-Van Stichelen ; Yiwen CuiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEvery year, about 18 million babies are born from mothers with gestational diabetes mellitus (GDM). While diabetic symptoms usually resolve after delivery, lasting complications can occur for both mother and child, including fetal overgrowth, type 2 diabetes (T2D), cardiovascular diseases, and obesity. The rapid progression of GDM is unique to pregnancies, and likely arises from placental dysfunction. Indeed, stress, nutrition and fetal gender are thought to trigger changes in pla...
Source: GEO: Gene Expression Omnibus - April 21, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

MYO ‐Inositol In Fermented Sugar Matrix Improves Human Macrophage Function
ConclusionThese observations indicate thatmyo-inositol in FPP influences multiple aspects of macrophage function critical for host defense against invading pathogens.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 24, 2022 Category: Food Science Authors: Nandini Ghosh, Amitava Das, Nirupam Biswas, Sanskruti P. Mahajan, Amit K. Madeshiya, Savita Khanna, Chandan K. Sen, Sashwati Roy Tags: Research Article Source Type: research

IKK ε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury
This study further revealed the mechanism of IKKε in inflammation and myocardial nutrition deprivation.PMID:34933200 | DOI:10.1016/j.bbrc.2021.12.047
Source: Biochemical and Biophysical Research communications - December 21, 2021 Category: Biochemistry Authors: Ganyi Chen Yueyue Xu Rui Fan Yafeng Liu Yiwei Yao Hongwei Jiang Qiyong Wu Liangpeng Li Wen Chen Xin Chen Source Type: research

Organic Cation Transporter I and Na+/taurocholate Co ?Transporting Polypeptide are Involved in Retrorsine? and Senecionine?Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirm previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.
Source: Molecular Nutrition and Food Research - December 11, 2021 Category: Food Science Authors: Anne ?Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Ptz, Albert Braeuning, Stefanie Hessel?Pras Tags: Research Article Source Type: research

Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway
In this study, we investigated the role and underlying molecular mechanism of Tau on protein synthesis and proliferation of C2C12 myoblast cells. Cells were treated with Tau (0, 60, 120, 180 and 240 μM) for 24 h. Tau dose-dependently promoted protein synthesis, cell proliferation, mTOR phosphorylation, and also AT-rich interaction domain 4B (ARID4B) expression, with the best stimulatory effects at 120 μM. LY 294002 treatment showed that Tau promoted ARID4B expression in a PI3K-dependent manner. ARID4B knockdown (by siRNA transfection for 24 h) prevented Tau from stimulating protein synthesis and cell proliferation, where...
Source: The British Journal of Nutrition - December 9, 2021 Category: Nutrition Authors: Qi Hao Lulu Wang Minghui Zhang Zhe Wang Meng Li Xuejun Gao Source Type: research