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Total 187 results found since Jan 2013.

25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research

Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1 α in mouse soleus muscles
J Clin Biochem Nutr. 2022 Sep;71(2):112-121. doi: 10.3164/jcbn.21-163. Epub 2022 May 26.ABSTRACTDietary β-carotene induces muscle hypertrophy and prevents muscle atrophy in red slow-twitch soleus muscles, but not in white fast-twitch extensor digitorum longus (EDL) muscles and gastrocnemius muscles. However, it remains unclear why these beneficial effects of β-carotene are elicited in soleus muscles. To address this issue, we focused on carotenoid transporters in skeletal muscles. In mice, Cd36 mRNA levels were higher in red muscle than in white muscle. The siRNA-mediated knockdown of CD36 decreased β-carotene uptake in...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Tomoya Kitakaze Takashi Sugihira Hiromichi Kameyama Asami Maruchi Yasuyuki Kobayashi Naoki Harada Ryoichi Yamaji Source Type: research

25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research

Cystine induced ‐mTORC2 activation through promoting Sin1 phosphorylation to suppress cancer cell ferroptosis
Conclusion: These results indicate that cystine-induced activation of the p38-Sin1-mTORC2-AKT pathway suppresses ferroptosis.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - October 3, 2022 Category: Food Science Authors: GuoYan Wang, Lei Chen, SenLin Qin, YiNing Zheng, Chao Xia, JunHu Yao, Ping Wang, Lu Deng Tags: Research Article Source Type: research

Intracellular ferritin heavy chain plays the key role in artesunate-induced ferroptosis in ovarian serous carcinoma cells
In conclusion, enhancement of ferritinophagy is an important step involved in the mechanism of Artesunate-induced ferroptosis, and ferritin heavy chain levels may contribute to the regulation of sensitivity in Artesunate-induced ferroptosis in ovarian serous carcinoma cells.PMID:35903602 | PMC:PMC9309081 | DOI:10.3164/jcbn.21-82
Source: Journal of Clinical Biochemistry and Nutrition - July 29, 2022 Category: Nutrition Authors: Tiger Koike Motoki Takenaka Noriko Suzuki Yoko Ueda Minako Mori Tasuku Hirayama Hideko Nagasawa Ken-Ichirou Morishige Source Type: research