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Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice
AbstractNutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more efficacious at the individual or genetic subgroup level relative to generic dietary advice. Nutrigenetics is unregulated, with no defined standards, beyond some commercially adopted codes of practice. Only a few official nutrition-related professional bodies have embraced the subject...
Source: Genes and Nutrition - December 15, 2017 Category: Nutrition Source Type: research

A scheme for a flexible classification of dietary and health biomarkers
AbstractBiomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is undergoing rapid development and new putative biomarkers are continuously emerging in the scientific literature. However, the existing concepts for classification of biomarkers in the dietary and health area may be ambiguous, leading to uncertainty about their application. In order to better understand the potential of biomarkers and to communicate their use and application, it is imperative to have a solid scheme f...
Source: Genes and Nutrition - December 12, 2017 Category: Nutrition Source Type: research

Fructose ingestion impairs expression of genes involved in skeletal muscle ’s adaptive response to aerobic exercise
ConclusionsOur results show that fructose ingestion impairs the expression of genes involved in biological processes relevant to exercise-induced remodeling of skeletal muscle. This might provide novel insight on how a dietary factor contributes to the genesis of disorders of glucose metabolism. (Source: Genes and Nutrition)
Source: Genes and Nutrition - December 8, 2017 Category: Nutrition Source Type: research

Ranges of phenotypic flexibility in healthy subjects
ConclusionThe results of the metabolic PhenFlex test in conjunction with the health space reliably assessed health on an individual basis. This quantification can be used in the future for personalized health quantification and advice. (Source: Genes and Nutrition)
Source: Genes and Nutrition - December 6, 2017 Category: Nutrition Source Type: research

Synbiotic effects of β-glucans from cauliflower mushroom and Lactobacillus fermentum on metabolic changes and gut microbiome in estrogen-deficient rats
ConclusionOVX changed gut microbiota and was associated with menopausal symptoms; however, the synbiotics, CFM and LFE, prevented menopausal symptoms and improved the gut microbiota in estrogen-deficient rats. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 9, 2017 Category: Nutrition Source Type: research

A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8
AbstractBackgroundThe solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) inSLC30A8 is associated with an increased risk of type 2 diabetes (T2D). We hypothesized that the association between zinc intake and T2D may be modified by theSLC30A8 genotype.ResultsWe carried out a prospective study among subjects with no history cardio-metabolic diseases in the Malm ö Diet and Cancer Study cohort (N = 26,132, 38% men; 86% with genotype data). Zinc intake was assessed using a diet questionnaire ...
Source: Genes and Nutrition - October 30, 2017 Category: Nutrition Source Type: research

Gene-nutrient interactions and susceptibility to human obesity
The objective of this review article is to provide concise and updated information on energy balance, heritability of body weight, origins of gene variants, and gene-nutrient interactions in relation to human obesity. It is proposed that knowledge of these related topics will provide valuable insight for future preventative lifestyle intervention using targeted nutritional and medicinal therapies. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 30, 2017 Category: Nutrition Source Type: research

Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition
ConclusionsTaken together, these results indicate a protective effect of MBC microbiota supplementation toward HFD-induced fat accumulation and triglyceride and cholesterol levels, as well as inflammation, suggesting a stronger effect of a mixed microbial consortium vs single-strain probiotic supplementation. The immunomodulatory activity exerted by the MBC microbiota could be due to synergistic interactions within the microbial consortium, highlighting the important role of dietary microbes with yet uncharacterised probiotic effect. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 4, 2017 Category: Nutrition Source Type: research

Does dietary fat affect inflammatory markers in overweight and obese individuals? —a review of randomized controlled trials from 2010 to 2016
ConclusionMost interventions showed either no or minor effects of dietary fat intake on inflammatory markers in overweight and obese subjects. To progress our understanding on how diet and dietary components affect our health, mechanistic studies are required. Hence, future studies should include whole diets and characterization of obese phenotypes at a molecular level, including omics data and gut microbiota. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 4, 2017 Category: Nutrition Source Type: research

Amino acid supplements and metabolic health: a potential interplay between intestinal microbiota and systems control
AbstractDietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and maintain immune homeostasis. Basic science and epidemiological results indicate that dietary macronutrient composition affects healthspan through multiple and integrated mechanisms, and their effects are closely related to the metabolic status to which they act. In particular, EAA supplementation can trigger different and even opposite effects depending on the catabolic and anabolic states of the organisms. Among...
Source: Genes and Nutrition - October 4, 2017 Category: Nutrition Source Type: research

Ancestors ’ dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism—the case of cofactor transporters
ConclusionsThese findings could support the importance of considering individual ’s genetic makeup along with their metabolic profile when tailoring personalized dietary interventions for optimizing health. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 4, 2017 Category: Nutrition Source Type: research

Dietary and health biomarkers —time for an update
AbstractIn the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects of specific dietary components, and biomarkers to assess the effects of diet on health. The implementation of biomarkers in nutritional research will be important to improve measurements of dietary intake, exposure to specific dietary components, and of compliance to dietary interventions. Biomarkers could also help with improved characterization of nutritional status in study volunteers and to provide much m...
Source: Genes and Nutrition - September 29, 2017 Category: Nutrition Source Type: research

Role of microRNAs in obesity and obesity-related diseases
AbstractIn recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in maintaining/altering physiological processes, including energy balance and metabolic homeostasis. Altered miRNAs expression has been reported in association with obesity, both in animal and human studies. Dysregulation of miRNAs may affect the status and functions of different tissues and organs, including the adipose tissue, pancreas, liver, and muscle, possibly contributing to metabolic abnormalities associated...
Source: Genes and Nutrition - September 25, 2017 Category: Nutrition Source Type: research

Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
AbstractBackgroundMethionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term methionine dietary modulation on the proximal jejunum, the section of the gut specifically responsible for amino acid absorption, in a mouse model. Eight-week-old CBA/J male mice were fed methionine-adequate (MAD; 6.5  g/kg) or methionine-supplemented (MSD; 19.5 g/kg) diets for 3.5 or 6 ...
Source: Genes and Nutrition - September 6, 2017 Category: Nutrition Source Type: research

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge
ConclusionThe PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of metabolic health. Studying both healthy subjects and subjects with impaired metabolic health showed that the PFT revealed new processes laying underneath health. This study provides the first evidence towards adopting the PFT as gold standard in nutrition research. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 29, 2017 Category: Nutrition Source Type: research

Lactase persistence in Tunisia as a result of admixture with other Mediterranean populations
ConclusionsOur study provided a first report of LP-associated alleles and haplotypes in the Tunisian population. We highlighted a gradient followed by LP diffusion from Europe to North Africa. Based on the rich historic background of Tunisia, we suggest that this adaptive trait was introduced in that geographic region by a relatively recent gene flow. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 24, 2017 Category: Nutrition Source Type: research

Formidable challenges to the notion of biologically important roles for dietary small RNAs in ingesting mammals
AbstractThe notion of uptake of active diet-derived small RNAs (sRNAs) in recipient organisms could have significant implications for our understanding of oral therapeutics and nutrition, for the safe use of RNA interference (RNAi) in agricultural biotechnology, and for ecological relationships. Yet, the transfer and subsequent regulation of gene activity by diet-derived sRNAs in ingesting mammals are still heavily debated. Here, we synthesize current information based on multiple independent studies of mammals, invertebrates, and plants. Rigorous assessment of these data emphasize that uptake of active dietary sRNAs is ne...
Source: Genes and Nutrition - July 7, 2017 Category: Nutrition Source Type: research

Bioavailability of transgenic microRNAs in genetically modified plants
ConclusionsThese preliminary results imply digestive stability and high expression levels of miRNAs in plants do not readily equate to bioavailability. This initial work suggests novel engineering strategies be employed to enhance miRNA bioavailability when attempting to use transgenic foods as a delivery platform. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 7, 2017 Category: Nutrition Source Type: research

Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study
ConclusionsOur observation suggests that AGT-rs699 and FTO-rs17817449 variants may contribute to the risk development of excess weight and an increase in the BMI, while IRS2-rs1805097 showed a protector effect; in addition, UCP3- rs1800849 showed a decreasing waist circumference. Socioeconomic and perinatal factors had no effect on the associations of the candidate gene. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 4, 2017 Category: Nutrition Source Type: research

Diet-derived microRNAs: unicorn or silver bullet?
AbstractIn ancient lore, a bullet cast from silver is the only effective weapon against monsters. The uptake of active diet-derived microRNAs (miRNAs) in consumers may be the silver bullet long sought after in nutrition and oral therapeutics. However, the majority of scientists consider the transfer and regulation of consumer ’s gene activity by these diet-derived miRNAs to be a fantasy akin to spotting a unicorn. Nevertheless, groups like Dr. Chen-Yu Zhang’s lab in Nanjing University have stockpiled breathtaking amounts of data to shoot down these naysayers. Meanwhile, Dr. Ken Witwer at John Hopkins has steadf...
Source: Genes and Nutrition - June 22, 2017 Category: Nutrition Source Type: research

Navigating dietary small RNAs
AbstractWhen a novel nutritional concept comes along, scientists become enthusiastic and start new explorations. In 2012, the field was enthralled with a study suggesting plant-based nucleic acid “information” acts as a bioactive to regulate animal metabolism. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 22, 2017 Category: Nutrition Source Type: research

Milk exosomes: beyond dietary microRNAs
AbstractExtracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line of research is slowed by a controversy whether the delivery and bioactivity of a single class of vesicle cargos, microRNAs, are real or not. This opinion paper argues that the evidence in support of the bioavailability of microRNAs encapsulated in dietary exosomes outweighs the evidence produced by scholars doubting that phenomenon is real. Importantly, this paper posits that the time is ripe to look beyond mi...
Source: Genes and Nutrition - June 22, 2017 Category: Nutrition Source Type: research

Obesity and microbiota: an example of an intricate relationship
AbstractIt is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In this context, animal studies and human trials have demonstrated that alterations of the intestinal microbiota towards enhanced energy harvest is a characteristic of the obese phenotype. Many publications, involving both animal studies and clinical trials, have reported on the successful exploitation of probiotics and prebiotics to treat obesity. However, the molecu...
Source: Genes and Nutrition - June 15, 2017 Category: Nutrition Source Type: research

Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature
ConclusionOverall, maternal folic acid supplementation before and during pregnancy seems to confer protection against the risk of childhood leukaemia in the offspring. The optimal folic acid requirements and supplementation doses need to be established, especially in conjunction with other vitamins in order to determine the most successful combinations of nutrients to maintain genomic health and wellbeing. Further research is therefore needed to uncover the role of maternal diet as a whole, as it represents a main factor capable of inducing permanent changes in the foetus. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 2, 2017 Category: Nutrition Source Type: research

Enrichment of in vivo transcription data from dietary intervention studies with in vitro data provides improved insight into gene regulation mechanisms in the intestinal mucosa
ConclusionsShort-term gene expression responses to dietary interventions as measured in the in vitro bioassay have a low predictability for long-term responses as measured in the intestinal mucosa in vivo. The short-term responses of a set regulatory and effector genes, as measured in this bioassay, however, provided additional insight into how specific processes in piglets and broilers may be modulated by “early” signalling molecules produced by enterocytes. The relevance of this set of regulatory/effector genes and cognate biological processes for zinc deficiency and supplementation, gluten allergy (rye), and...
Source: Genes and Nutrition - April 13, 2017 Category: Nutrition Source Type: research

Transcriptomic responses of the liver and adipose tissues to altered carbohydrate-fat ratio in diet: an isoenergetic study in young rats
ConclusionsThese results indicate that the alteration of dietary C-F balance differentially affects the transcriptomes of metabolizing and energy-storing tissues. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 8, 2017 Category: Nutrition Source Type: research

Brain xanthophyll content and exploratory gene expression analysis: subspecies differences in rhesus macaque
ConclusionsThese results indicate that origin is related to differences in both gene expression and xanthophyll content in the brain. Findings from this study may have important implications regarding genetic diversity, lutein status, and cognition in primates. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 7, 2017 Category: Nutrition Source Type: research

Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise
ConclusionsAn acute bout of heavy-load strength exercise, followed by protein supplementation, caused overlapping, but also unique, responses in skeletal muscle and PBMCs, suggesting tissue-specific functions in response to exercise. However, no different effects of the different protein supplements were observed. Altered mRNA expressions in PBMCs of older participants may affect regenerative mechanisms. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 2, 2017 Category: Nutrition Source Type: research

Effect of different concentrations of omega-3 fatty acids on stimulated THP-1 macrophages
ConclusionsThese results suggest that in stimulated macrophages, expression levels of genes involved in inflammation are influenced by the dose, the type of n-3 FAs, and the time of incubation. (Source: Genes and Nutrition)
Source: Genes and Nutrition - February 20, 2017 Category: Nutrition Source Type: research

Food components and contaminants as (anti)androgenic molecules
AbstractAndrogens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood, androgens remain essential for the maintenance of male reproductive function and behavior. Androgens, acting through the androgen receptor (AR), regulate male sexual differentiation during development, sperm production beginning from puberty, and maintenance of prostate homeostasis. Several substances present in the environment, now classified as endocrine disruptors (EDCs), strongly interfere with androgen ...
Source: Genes and Nutrition - February 15, 2017 Category: Nutrition Source Type: research

The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility
ConclusionsOur study shows that applying the challenge test concept is able to reveal previously unidentified correlations between specific micronutrients and health-related processes, with potential relevance for maintenance of health that were not observed by correlating homeostatic measurements. This approach will contribute to insights on the influence of micronutrients on health and help to create efficient micronutrient intervention programs. (Source: Genes and Nutrition)
Source: Genes and Nutrition - February 7, 2017 Category: Nutrition Source Type: research

A porcine gluteus medius muscle genome-wide transcriptome analysis: dietary effects of omega-6 and omega-3 fatty acids on biological mechanisms
ConclusionsSummarizing, obtained results provide strong evidence that omega-6 and omega-3 fatty acids regulate fundamental metabolic processes in muscle tissue development and functioning. (Source: Genes and Nutrition)
Source: Genes and Nutrition - January 30, 2017 Category: Nutrition Source Type: research

Propelling the paradigm shift from reductionism to systems nutrition
AbstractThe complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, cell, and microbial models have been extensively used to address questions that could not be pursued experimentally in humans, posing an additional level of complexity in translation of the results to healthy and diseased metabolism. The past few decades have witnessed a surge in development of increasingly sensitive molecular techniques and bioinformatic tools for storing, managing, and analyzing increasingly ...
Source: Genes and Nutrition - January 24, 2017 Category: Nutrition Source Type: research

Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat ’s liver
ConclusionsThese studies support the notion that the regulation of both Elovl and desaturase expression may play an important role in managing hepatic lipid composition in response to changes in dietary status. (Source: Genes and Nutrition)
Source: Genes and Nutrition - January 24, 2017 Category: Nutrition Source Type: research

Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny
ConclusionsThese results suggest that epigenetic factors in the embryo/fetus influence behavioral and epigenetic phenotypes of progenies. Significant epigenetic alterations in the brains of the progenies induced by the maternal-protein restriction were observed in the present study. To our knowledge, this is first study to evaluate the effect of maternal hyponutrition on behavioral phenotypes using reproductive technology. (Source: Genes and Nutrition)
Source: Genes and Nutrition - January 18, 2017 Category: Nutrition Source Type: research

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells
ConclusionsOur study demonstrates that γ- and δ-T3 induce apoptosis also in tumor cells lacking of ERβ by triggering signals originating from endoplasmic reticulum stress. Our observations suggest that tocotrienols could have a significant role in tumor cell physiology and a possible therapeutic potential. (Source: Genes and Nutrition)
Source: Genes and Nutrition - December 22, 2016 Category: Nutrition Source Type: research

Erratum to: 18 β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation
(Source: Genes and Nutrition)
Source: Genes and Nutrition - November 22, 2016 Category: Nutrition Source Type: research

Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon
ConclusionsOur data indicate thatApoa4,Ppap2b,Cel, andClps are candidate early marker genes associated with obesity-related pathological changes in the colon. Genome-wide analyses performed in the present study provide new insights on selecting novel genes that may be associated with the development of diseases of the colon. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 21, 2016 Category: Nutrition Source Type: research

Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats
ConclusionThe results obtained suggest that the anti-diabetic effects of PFJ may be due to mechanisms other than an increase in insulin secretion. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 21, 2016 Category: Nutrition Source Type: research

Improper hydration induces global gene expression changes associated with renal development in infant mice
ConclusionsAltogether, we demonstrate transcriptional events during renal development in infancy and show that the impacts of inadequate water intake in the early postnatal state heavily rely on the impairment of normal renal development. Here, we provide a meaningful perspective of renal development in infancy with a molecular and physiological explanation of why infants are more vulnerable to dehydration than adults. These results provide new insights into the molecular effects of dehydration on renal physiology and indicate that optimal nutritional interventions are necessary for pediatric renal development. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 19, 2016 Category: Nutrition Source Type: research

The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport
ConclusionsChanges in cholesterol transport may contribute to altered tissue development in the fetus and hence programme risk of disease in later life. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 11, 2016 Category: Nutrition Source Type: research

Effect of diets supplemented with different conjugated linoleic acid (CLA) isomers on protein expression in C57/BL6 mice
ConclusionsAdministration of CLA in humans has to be carefully personalized, since even considering the presence of a species-specific effect, adverse effects might occur on long-term supplementation. Here we demonstrated that, in mouse, CLA is effective in reducing fat mass, but it also induces liver steatosis. The increase of lean mass is linked to an induction of cell proliferation, which, on long-term supplementation, might also lead to adverse effects. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 3, 2016 Category: Nutrition Source Type: research

The impact of MTHFR 677C  → T risk knowledge on changes in folate intake: findings from the Food4Me study
ConclusionsThese results suggest that knowledge ofMTHFR 677C  → T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant.Trial registrationClinicalTrials.govNCT01530139 (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 28, 2016 Category: Nutrition Source Type: research

Erratum to: Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation
(Source: Genes and Nutrition)
Source: Genes and Nutrition - August 15, 2016 Category: Nutrition Source Type: research

Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup ’ik people
ConclusionWe provide evidence of linkage between several biologically plausible genomic regions and vitamin D metabolism in a circumpolar population. Additionally, these findings suggest that a traditional dietary pattern may modulate genetic effects on circulating vitamin D. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 1, 2016 Category: Nutrition Source Type: research

Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation
Conclusions We show for the first time that EFA-CLA can regulate genes engaged in AKT/mTOR pathway and inhibiting cell cycle progression. The observed results are most likely achieved by the combined effect of both: incorporated CLA isomers and other fatty acids in eggs organically modified through hens ’ diet. Our results suggest that CLA-enriched eggs could be easily available food products with a potential of a cancer chemopreventive agent. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 26, 2016 Category: Nutrition Source Type: research

Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species
Conclusions We found that VAAM ingestion had an effect on multiple tissue transcriptomes of freely moving mice. Utilization of glycogenic amino acids may have been activated in the liver. Fatty acid conversion into phospholipid, not to triacylglycerol, may have been stimulated in adipocytes contrasting that a little effect was observed in BAT. Analysis of upstream factors revealed that multiple hormonal signals were activated in the liver, WAT, and BAT. Our data provide some clues to understanding the role of VAAM in metabolic regulation. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 10, 2016 Category: Nutrition Source Type: research

Coordinated regulation of hepatic and adipose tissu/e transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species
Conclusions We found that VAAM ingestion had an effect on multiple tissue transcriptomes of freely moving mice. Utilization of glycogenic amino acids may have been activated in the liver. Fatty acid conversion into phospholipid, not to triacylglycerol, may have been stimulated in adipocytes contrasting that a little effect was observed in BAT. Analysis of upstream factors revealed that multiple hormonal signals were activated in the liver, WAT, and BAT. Our data provide some clues to understanding the role of VAAM in metabolic regulation. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 10, 2016 Category: Nutrition Source Type: research

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort
Conclusion We found some evidence of an interaction between diet quality and GRSLDL-C on ischemic stroke. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 6, 2016 Category: Nutrition Source Type: research

Metallothioneins 1 and 2, but not 3, are regulated by nutritional status in rat white adipose tissue
Conclusions This study showed that the expressions of MT1 and MT2 genes in WAT are regulated by nutritional status, and the regulation may be independent of total zinc concentration. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 22, 2016 Category: Nutrition Source Type: research