Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model
ConclusionsTaken together, our findings suggest that AA has greater beneficial effects on metabolism in HFD-fedGLUT10G128E mice than HFD-fed WT mice. As such, AA plays an important role in supporting eWAT development and attenuating HFD-induced metabolic dysregulation inGLUT10G128E mice. Our results suggest that proper WAT development is essential for metabolic regulation later in life. Furthermore, when considering the usage of AA as a complementary nutrition for prevention and treatment of T2DM, individual differences in genetics and dietary patterns should be taken into account. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 16, 2022 Category: Nutrition Source Type: research
Purple grape juice improves performance of recreational runners, but the effect is genotype dependent: a double blind, randomized, controlled trial
ConclusionThe ergogenic effect of grape juice was genotype-dependent for SOD3 Arg213Gly. However, biochemical redox balance markers did not explain this difference. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 2, 2022 Category: Nutrition Source Type: research
Genetic support of a causal relationship between iron status and atrial fibrillation: a Mendelian randomization study
ConclusionIn conclusion, our results strongly elucidated a causal link between genetically determined higher iron status and increased risk of atrial fibrillation. This provided new ideas for the clinical prevention and treatment of atrial fibrillation. (Source: Genes and Nutrition)
Source: Genes and Nutrition - May 30, 2022 Category: Nutrition Source Type: research
Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice
ConclusionsWe have shown for the first time that mechanical loading of bone and early life vitamin D deficiency leads to changes in the epigenome of this tissue in key genes in the vitamin D and osteoblast differentiation pathway. (Source: Genes and Nutrition)
Source: Genes and Nutrition - May 26, 2022 Category: Nutrition Source Type: research
Impact of anthocyanin on genetic stability in mammary adenocarcinoma-induced mice treated with methotrexate
ConclusionsThere was a decrease in genetic instability and DNA damage in the tumor-bearing mice treated with anthocyanin, with a concomitant increase in nuclear poly[adenosine diphosphate (ADP)-ribose] polymerase activity, compared with those of the untreated group. Anthocyanin exerted positive effects in the treatment of mammary adenocarcinoma. (Source: Genes and Nutrition)
Source: Genes and Nutrition - May 5, 2022 Category: Nutrition Source Type: research
Interactions between red and processed meat consumption and APOA5 gene variants associated with the incidence of metabolic syndrome in Korean adults
ConclusionsAn association between the presence of the minor alleles of rs662799 and high red and processed meat consumption and the incidence of MetS was observed in Korean adults. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 25, 2022 Category: Nutrition Source Type: research
Genistein protects against ultraviolet B –induced wrinkling and photoinflammation in in vitro and in vivo models
ConclusionsGenistein could be used as a safe and natural compound for use in novel anti-inflammatory agents for topical application.Graphical abstractThe experimental design procedure, including the skin parameter and blood serum measurements of 137 participants. Genistein-rich compounds provide protection against UVB-induced inflammation, as determined using in vitro and in vivo animal model experiments. (Source: Genes and Nutrition)
Source: Genes and Nutrition - February 24, 2022 Category: Nutrition Source Type: research
Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma
ConclusionTaken together, this study firstly confirmed PD-L1 expression and signaling are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in TSCC. Our study provides a sounder basis for comprehending PD-L1 signaling and expression and prevention and treatment of TSCC. (Source: Genes and Nutrition)
Source: Genes and Nutrition - February 14, 2022 Category: Nutrition Source Type: research
Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control
ConclusionsGenetically predicted increase in Vit-D status [25(OH)D] may confer secondary protection against incident combined CVD events and myocardial infarction in a hypertensive-diabetic population where serological 25(OH)D deficiency is common, through facilitating blood pressure control. (Source: Genes and Nutrition)
Source: Genes and Nutrition - January 29, 2022 Category: Nutrition Source Type: research
Gut microbiota in patients with obesity and metabolic disorders — a systematic review
ConclusionsWe identified specific bacteria associated with obesity and metabolic disorders in western and eastern populations. Mechanistic studies are required to determine whether these microbes are a cause or product of obesity and metabolic disorders. (Source: Genes and Nutrition)
Source: Genes and Nutrition - January 29, 2022 Category: Nutrition Source Type: research
An interferon-related signature characterizes the whole blood transcriptome profile of insulin-resistant individuals —the CODAM study
ConclusionsWe present an approach to investigate the whole blood transcriptome of insulin-resistant individuals, independent of their DNA methylation-derived white blood cell profile. An interferon-related signature characterizes the whole blood transcriptome profile of the insulin-resistant individuals, independent of their white blood cell profile. The observed signature indicates increased systemic inflammation possibly due to an innate immune response and whole-body insulin resistance, which can be a cause or a consequence of insulin resistance. Altered gene expression in specific organs may be reflected in whole blood...
Source: Genes and Nutrition - December 9, 2021 Category: Nutrition Source Type: research
Effect of AMY1 copy number variation and various doses of starch intake on glucose homeostasis: data from a cross-sectional observational study and a crossover meal study
ConclusionsStarch intake modified the observed association betweenAMY1 CNV and fasting glucose and BMI. Furthermore, depending on the starch dose, a higher postprandial glucose and insulin response was observed in individuals with highAMY1 CN than in those with lowAMY1 CN.Trial registrationClinicalTrials.gov,NCT03974126. Registered 4 June 2019 —retrospectively registered. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 17, 2021 Category: Nutrition Source Type: research
Genetic predisposition to impaired metabolism of the branched chain amino acids, dietary intakes, and risk of type 2 diabetes
ConclusionsOur study suggests that genetic predisposition to BCAA metabolism disorder modifies the effect of dietary BCAA intakes on T2D risk as well as HbA1c and that higher BCAA intakes exert an unfavorable effect on type 2 diabetes risk and HbA1c only among those with high genetic susceptibility. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 2, 2021 Category: Nutrition Source Type: research
Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer ’s disease
ConclusionWe demonstrated that there may be no causal association between plasma vitamin C levels and the risk of AD in people of European descent. The insistent findings in clinically diagnosed AD and AD proxy phenotype may be caused by the phenotypic heterogeneity. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 29, 2021 Category: Nutrition Source Type: research
Correction to: Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms
(Source: Genes and Nutrition)
Source: Genes and Nutrition - October 19, 2021 Category: Nutrition Source Type: research
