25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality
ConclusionThis study provides evidence for a shared genetic overlap between 25(OH)D and ASD. Bidirectional MR analysis also did not show a definite causal relationship between 25(OH)D and ASD. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 26, 2023 Category: Nutrition Source Type: research
Biomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review
In conclusion, common biomarkers of alcohol intake, e.g., as ethyl glucuronide, ethyl sulfate, fatty acid ethyl esters, and phosphatidyl ethanol, show considerable inter-individual response, especially at low to moderate intakes, and need further development and improved validation, while BFIs for beer and wine are highly promising and may help in more accurate intake assessments for these specific beverages. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 19, 2023 Category: Nutrition Source Type: research
Role of muscle FOXO gene in exercise against the skeletal muscle and cardiac age-related defects and mortality caused by high-salt intake in Drosophila
AbstractFOXO has long been associated with aging, exercise, and tissue homeostasis, but it remains unclear what the role is of the muscle FOXO gene in E against high-salt intake(HSI)-induced age-related defects of the skeletal muscle, heart, and mortality. In this research, overexpression and RNAi of the FOXO gene in the skeletal and heart muscle ofDrosophila were constructed by building Mhc-GAL4/FOXO-UAS-overexpression and Mhc-GAL4/FOXO-UAS-RNAi system. The skeletal muscle and heart function, the balance of oxidation and antioxidant, and mitochondrial homeostasis were measured. The results showed that exercise reversed th...
Source: Genes and Nutrition - March 30, 2023 Category: Nutrition Source Type: research
Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity
ConclusionsThe results from this study indicate disrupted mitochondrial FOCM impairs mitochondrial folate accumulation and respiration, mitochondrial formate production, glycolytic activity, and cellular proliferation. These changes persist even after a potentially compensatory increase in mitochondrial biogenesis as a result of decreased SHMT2 levels. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 24, 2023 Category: Nutrition Source Type: research
Impairment of electron transport chain and induction of apoptosis by chrysin nanoparticles targeting succinate-ubiquinone oxidoreductase in pancreatic and lung cancer cells
ConclusionTreatment with CCNPs improved the effect of chrysin on succinate-ubiquinone oxidoreductase activity and expression and therefore has the potential as a more efficient formulation than chemotherapy to prevent metastasis and angiogenesis by targeting HIF-1 α in PDAC and lung cancer. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 11, 2023 Category: Nutrition Source Type: research
Associations between dietary intake and glucose tolerance in clinical and metabolomics-based metabotypes
ConclusionMetabotyping may be a useful tool to tailor dietary interventions that will benefit specific groups of individuals. The variables that are used to create metabotypes will affect the association between dietary intake and disease risk. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 10, 2023 Category: Nutrition Source Type: research
Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer ’s disease: potential interactive effects of APOE genotype with dietary fats
AbstractAlzheimer ’s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by brain parenchymal abundance of amyloid-beta (Aβ) and the accumulation of lipofuscin material that is rich in neutral lipids. However, the mechanisms for aetiology of AD are presently not established. There is increasing evidence that metabolism of lipoprotein-Aβ in blood is associated with AD risk, via a microvascular axis that features breakdown of the blood-brain barrier, extravasation of lipoprotein-Aβ to brain parenchyme and thereafter heightened inflammation. A peripheral lipoprotein-Aβ/capil lary axis f...
Source: Genes and Nutrition - February 25, 2023 Category: Nutrition Source Type: research
Correction: Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome: a double blind randomized controlled trial
(Source: Genes and Nutrition)
Source: Genes and Nutrition - January 27, 2023 Category: Nutrition Source Type: research
Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome: a double blind randomized controlled trial
ConclusionThis current study showed that the administration of green cardamom is a beneficial approach for improving anthropometric, glycemic, and androgen hormones, as well as obesity and diabetes genes expression in PCOS women under the low-calorie diet.Trial registrationThis trial was registered with the Iranian Clinical Trials Registry (registration number: IRCT20200608047697N1). 1 August, 2020;https://www.irct.ir/trial/48748 (Source: Genes and Nutrition)
Source: Genes and Nutrition - December 15, 2022 Category: Nutrition Source Type: research
Comparison of apical and basolateral Cu treatment for iron-related gene regulation during deferoxamine induced iron deficiency
ConclusionsCu level in the basolateral side of Caco-2 cells significantly influenced the intracellular gene regulation in DFO-induced iron-deficient condition, and polarization of the cells might be important factor gene regulation in enterocyte cells. (Source: Genes and Nutrition)
Source: Genes and Nutrition - December 9, 2022 Category: Nutrition Source Type: research
Prebiotic/probiotic supplementation resulted in reduced visceral fat and mRNA expression associated with adipose tissue inflammation, systemic inflammation, and chronic disease risk
ConclusionThe key findings support that 90-day prebiotic/probiotic supplementation may be associated with reduced adipose tissue inflammation, reduced systemic inflammation, and reduced chronic disease risk. Combined with the unexpected finding of reduced VAT, this intervention may have resulted in improved overall health and reduced chronic disease risk. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 28, 2022 Category: Nutrition Source Type: research
Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus
ConclusionsThe CC or CG genotype carriers in rs7747752 ofCDKAL1 who have a low serum level of L-carnitine or choline are at a particular high risk of GDM. Randomized controlled trials are warranted to test the effect of supplement of L-carnitine or choline on the risk of GDM in the high-risk group. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 1, 2022 Category: Nutrition Source Type: research
Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross
ConclusionsGenetic background affected hepatic gene expression in the CC overall, but diet macronutrient differences also altered expression of a specific subset of genes. Changes in macronutrient composition altered gene expression related to metabolic processes, while genetic background heavily influenced a broad range of cellular functions and processes irrespective of adiposity. Understanding the individual role of macronutrient composition, genetics, and their interaction is critical to developing therapeutic strategies and policy recommendations for precision nutrition. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 10, 2022 Category: Nutrition Source Type: research
Association of phenylthiocarbamide perception with anthropometric variables and intake and liking for bitter vegetables
AbstractPhenylthiocarbamide (PTC) sensitivity, a sensory trait mediated by the bitter taste receptor 38 (TAS2R38), has been described as a promising biomarker of health status or disease risk. The aim of this cross-sectional study was to evaluate the influence of PTC phenotypes on (1) individual anthropometric and clinical history variables; (2) other basic taste recognition thresholds (RTs), and (3) the hedonic perception and habitual intake ofBrassicaceae vegetables in a young adult population (18.9 ± 1.7 years old). The PTC phenotype was determined by the quantitative measure of the PTC recognition threshold (no...
Source: Genes and Nutrition - July 27, 2022 Category: Nutrition Source Type: research
MicroRNA-205-5p plays a suppressive role in the high-fat diet-induced atrial fibrosis through regulation of the EHMT2/IGFBP3 axis
ConclusionThis study suggests that miR-205-5p attenuates HFD-induced atrial fibrosis via modulating the EHMT2/IGFBP3 axis.Graphical AbstractmiR-205-5p alleviates high-fat diet-induced atrial fibrosis in mice via EHMT2/IGFBP3. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 20, 2022 Category: Nutrition Source Type: research
