Will guidelines on alcohol consumption be personalized by a genetic approach?
(Source: Genes and Nutrition)
Source: Genes and Nutrition - January 25, 2021 Category: Nutrition Source Type: research
Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning/memory abilities
ConclusionsIn conclusion, genes and pathways associated with neurodevelopment and learning/memory abilities were differentially methylated in male rat offspring in response to maternal FA deficiency or supplementation during pregnancy. (Source: Genes and Nutrition)
Source: Genes and Nutrition - January 11, 2021 Category: Nutrition Source Type: research
DNA methylation during human adipogenesis and the impact of fructose
ConclusionsOur studies demonstrate that DNA methylation regulates or marks the transformation of morphologically differentiating adipocytes (seen at 192 h), to the more mature and metabolically robust adipocytes (as seen at 384 h) in a genome-wide manner. Lower (2.5 mM) concentrations of fructose have the most robust effects on methylation compared to higher concentrations (5 and 10 mM), suggesting that fructose may be playing a signaling/r egulatory role at lower concentrations of fructose and as a substrate at higher concentrations. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 26, 2020 Category: Nutrition Source Type: research
Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies
ConclusionThe present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of postmenopausal osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis in postmenopausal women. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 25, 2020 Category: Nutrition Source Type: research
Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian
ConclusionsOur study confirmed the association of GRS with higher BMI and further showed a significant effect of the GRS on WC and triglyceride levels through the influence of a low-protein diet. These findings suggest that following a lower protein diet, particularly in genetically predisposed individuals, might be an effective approach for addressing cardiometabolic diseases among Southeast Asian women. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 12, 2020 Category: Nutrition Source Type: research
Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions
ConclusionsThe interactions between a high folate level and unmethylated p16 and p53 promoter regions may have a strong preventive effect on esophageal carcinogenesis. Additionally, a high folate level may offset the tumor-promoting effects of aberrant DNA methylation of the genes, but it is also noteworthy that a very high level of folate may not have a protective effect on EPL in some cases. (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 28, 2020 Category: Nutrition Source Type: research
Food intake biomarkers for berries and grapes
AbstractGrapes and berries are two types of widely consumed fruits characterized by a high content in different phytochemicals. However, their accurate dietary assessment is particularly arduous, because of the already wide recognized bias associated with self-reporting methods, combined with the large range of species and cultivars and the fact that these fruits are popularly consumed not only in fresh and frozen forms but also as processed and derived products, including dried and canned fruits, beverages, jams, and jellies. Reporting precise type and/or quantity of grape and berries in FFQ or diaries can obviously be af...
Source: Genes and Nutrition - September 22, 2020 Category: Nutrition Source Type: research
Predictors of stakeholders ’ intention to adopt nutrigenomics
ConclusionThe findings of this study suggest that the intentions of Malaysian stakeholders to adopt nutrigenomics are a complex decision-making process where all the previously mentioned factors interact. Although the results showed that the stakeholders in Malaysia were highly positive towards nutrigenomics, they were also cautious about adopting it. (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 21, 2020 Category: Nutrition Source Type: research
Low-grade chronic inflammation is attenuated by exercise training in obese adults through down-regulation of ASC gene in peripheral blood: a pilot study
ConclusionLow-grade chronic inflammation was attenuated through individualized exercise prescription and our findings highlight the role of theASC gene in the inflammation of obese adults.Trial registrationClinicalTrials.gov, numberNCT04315376. Registered 20 March 2020 —retrospectively registered (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 26, 2020 Category: Nutrition Source Type: research
Testosterone deficiency caused by castration increases adiposity in male rats in a tissue-specific and diet-dependent manner
ConclusionsTestosterone deficiency increases adiposity in a tissue-specific and diet-dependent manner. Testosterone deficiency decreases body and muscle weights and downregulates androgen signaling. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 16, 2020 Category: Nutrition Source Type: research
Melanocortin-4 receptor (MC4R) rs17782313 polymorphism interacts with Dietary Approach to Stop Hypertension (DASH) and Mediterranean Dietary Score (MDS) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals
ConclusionMC4R rs17782313 interacts with healthy dietary pattern (DASH score and MDS) to influence cardio-metabolic risk factors and hypothalamic hormones in obese individuals. Prospective cohort studies are needed to further assess these findings. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 4, 2020 Category: Nutrition Source Type: research
Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice
ConclusionAlteration of gut microbiota induced by antibiotic use may affect the expression of adiponectin and resistin in mice fed the high-fat diet by modifying promoter DNA methylation, thus leading to increased fatty acid oxidation and less body weight gain. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 25, 2020 Category: Nutrition Source Type: research
Biomarkers of intake for tropical fruits
AbstractConsumption of fruit and vegetable is a key component of a healthy and sustainable diet. However, their accurate dietary assessment remains a challenge. Due to errors in self-reporting methods, the available dietary information is usually biased. Biomarkers of intake constitute objective tools to better reflect the usual or recent consumption of different foods, including fruits and vegetables. Partners of The Food Biomarker Alliance (FoodBall) Project have undertaken the task of reviewing the available literature on putative biomarkers of tropical fruit intake. The identified candidate biomarkers were subject to v...
Source: Genes and Nutrition - June 18, 2020 Category: Nutrition Source Type: research
Genetic risk prediction of the plasma triglyceride response to independent supplementations with eicosapentaenoic and docosahexaenoic acids: the ComparED Study
ConclusionResults of the present study suggest that the constructed GRS is a good predictor of the plasma TG response to supplementation with either DHA or EPA.Trial registrationClinicalTrials.gov,NCT01810003. The study protocol was registered on March 4, 2013. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 14, 2020 Category: Nutrition Source Type: research
Effect of flaxseed oil supplementation on the erythrocyte membrane fatty acid composition and endocannabinoid system modulation in patients with coronary artery disease: a double-blind randomized controlled trial
ConclusionFlaxseed oil supplementation could attenuate the ECS tone by decreasing the AEA level and increasing CB2 mRNA expression. Therefore, flaxseed oil may be considered a promising agent with cardioprotective properties. (Source: Genes and Nutrition)
Source: Genes and Nutrition - May 4, 2020 Category: Nutrition Source Type: research
